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Dergiler / Medical Records / 2026 / Sayı: 1

Seboreik dermatitte serum Çinko, Selenyum ve D vitamini düzeyleri: vaka kontrol çalışması

Serum Zinc, Selenium and Vitamin D Levels in Seborrheic Dermatitis: A Case-Control Study

Hamza Aktaş(UNIVERSITY OF HEALTH SCIENCES, DİYARBAKIR GAZİ YAŞARGİL HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE, THE DEPARTMENT OF DERMATOLOGY)0000-0003-3610-500X
Mehmet Semih Çelik(UNIVERSITY OF HEALTH SCIENCES, DİYARBAKIR GAZİ YAŞARGİL HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE, THE DEPARTMENT OF DERMATOLOGY)0000-0002-3378-0619
Yunus Yakut(UNIVERSITY OF HEALTH SCIENCES, DİYARBAKIR GAZİ YAŞARGİL HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE, THE DEPARTMENT OF DERMATOLOGY)
Serhat Özdemir(UNIVERSITY OF HEALTH SCIENCES, DİYARBAKIR GAZİ YAŞARGİL HEALTH RESEARCH CENTER, DEPARTMENT OF INTERNAL MEDICINE, THE DEPARTMENT OF DERMATOLOGY)
Sayfa
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Yayın Tarihi
2026-03-24
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Gruplar arasında çinko düzeyleri açısından anlamlı bir fark saptanmadı (p=0.750).

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Amaç: Seboreik dermatit (SD), relapslarla seyreden, etiyolojisi bilinmeyen, hastaların yaşam kalitesini etkileyen kronik bir inflamatuvar cilt hastalığıdır.
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Temel Bulgular & Veri:Yapılan çalışmalar, vitamin ve mineral eksikliklerinin hastalığın seyrini etkileyebileceğini öne sürmektedir.
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Sonuç & Katkı:Bulgular: Gruplar arasında çinko düzeyleri açısından anlamlı bir fark saptanmadı (p=0.750).
🔬Tür:Klinik Araştırma
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:seboreik dermatit · selenyum · vitaminD

Özet

Amaç: Seboreik dermatit (SD), relapslarla seyreden, etiyolojisi bilinmeyen, hastaların yaşam kalitesini etkileyen kronik bir inflamatuvar cilt hastalığıdır. Yapılan çalışmalar, vitamin ve mineral eksikliklerinin hastalığın seyrini etkileyebileceğini öne sürmektedir. Bu vaka-kontrol çalışmasında SD hastalarında serum D vitamini, selenyum ve çinko düzeyleri sağlıklı kontrol grubuyla karşılaştırılarak değerlendirildi. Gereç ve Yöntemler: Çalışmaya 152 SD hastası ve 129 sağlıklı kontrol, demografik veriler ve kan örnekleri sağlanarak katıldı. Hastalığın şiddeti SEDASI puanlama sistemi kullanılarak değerlendirildi. Serum D vitamini, selenyum ve çinko düzeyleri ELISA ve fotometrik yöntemler kullanılarak ölçüldü. İstatistiksel analizler SPSS v27 ve JAMOVI yazılımları ile gerçekleştirildi ve ki-kare testleri kullanılarak gerçekleştirildi. Tüm testlerde istatistiksel anlamlılık düzeyi p < 0.05 olarak kabul edildi. Bulgular: Gruplar arasında çinko düzeyleri açısından anlamlı bir fark saptanmadı (p=0.750). Ancak selenyum (p<0.001) ve D vitamini düzeyleri (P=0.036) hasta grubunda kontrol grubuna göre istatiksel olarak anlamlı olacak şekilde daha düşük saptandı. Ayrıca selenyum düzeyleri ile hastalık şiddeti arasında ters korelasyon saptandı. Sonuç: Çalışmada selenyum ve D vitamini düzeyleri açısından hasta ve kontrol grubunda belirgin fark saptandı. Ayrıca hastalık şiddeti ile selenyum düzeyleri arasında ters korelasyon mevcuttu. Bu bulgular, SD'nin yönetiminde besin takviyesinin potansiyel terapötik rolüne ilişkin daha fazla araştırma yapılması gerektiğini vurgulamaktadır.

Abstract

Aim: Chronic inflammation of the skin is a hallmark of seborrheic dermatitis (SD) with relapsing episodes and unknown etiology, which affects the patients' quality of life. Studies suggest that a lack of vitamins and minerals could influence the course of the disease. In this case-control study, serum vitamin D, selenium, and zinc levels of patients with SD were compared with those of a healthy control group. Material and Methods: The study included 152 patients with SD and 129 healthy controls, from whom demographic data and blood samples were collected. Disease severity was assessed using the SEDASI scoring system. Serum vitamin D and zinc levels were measured using ELISA and photometric methods, while selenium levels were also determined. Statistical analyses were performed using SPSS version 27 and JAMOVİ software, and chi-square tests were also conducted. Statistical significance was defined as p < 0.05 for all tests. Results: No significant difference in zinc levels was observed between the groups (p=0.750). However, selenium (p<0.001) and The patient group exhibited statistically significantly lower vitamin D levels (p=0.036) than the control group. Furthermore, A statistically significant negative correlation was observed between selenium levels and disease severity Conclusion: In the study, The patient and control groups showed significant differences regarding selenium and vitamin D levels. Additionally, Disease severity and selenium levels were negatively correlated. These findings highlight the need for further research regarding the potential therapeutic role of nutritional supplementation in the management of SD.

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Bu Makaleye Atıf Yap

Aktaş, H., Çelik, M. S., Yakut, Y., Özdemir, S. (2026). Seboreik dermatitte serum Çinko, Selenyum ve D vitamini düzeyleri: vaka kontrol çalışması. Medical Records, Sayı: 1. https://doi.org/10.37990/medr.1767596

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