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Dergiler / Medical Records / 2024 / Cilt: 6 Sayı: 3

Prevalence of Hepatitis B Serology and Reactivation in Rheumatology Patients Receiving Biologic or Targeted Synthetic Disease-Modifying Antirheumatic Drugs

Derya Çırakoğlu(ORDU ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-7827-8032
Emine Serap Yılmaz(ORDU ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-5308-4488
Sayfa
542–545
Yayın Tarihi
2024-09-24
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

However, the use of biologics in these patients poses a low risk of HBVr.

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Amaç & Hipotez:Aim: This study sought to assess hepatitis B virus (HBV) serology and the incidence of HBV reactivation (HBVr) in rheumatology patients with resolved hepatitis B infection (HBsAg negative and HBcAb positive) who were undergoing treatment with biologic or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs).
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Temel Bulgular & Veri:Results: The study included a total of 316 patients, of whom 217 (68.7%) were diagnosed with ankylosing spondylitis, 74 (23.4%) with rheumatoid arthritis, and 25 (7.9%) with psoriatic arthritis.
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Sonuç & Katkı:However, the use of biologics in these patients poses a low risk of HBVr.
🔬Tür:Literatür & Derleme Çalışması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Biologic therapy · b/tsDMARD · hepatitis B virus reactivation

Abstract

Aim: This study sought to assess hepatitis B virus (HBV) serology and the incidence of HBV reactivation (HBVr) in rheumatology patients with resolved hepatitis B infection (HBsAg negative and HBcAb positive) who were undergoing treatment with biologic or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs). Material and Method: Data from rheumatology patients treated with b/tsDMARDs were retrospectively reviewed from the electronic records. The demographic data, the anti-rheumatic drugs used, and the hepatitis serologies (HBsAg, anti-HBc IgG, anti-HBs, and anti-HCV) of the patients were analyzed. Results: The study included a total of 316 patients, of whom 217 (68.7%) were diagnosed with ankylosing spondylitis, 74 (23.4%) with rheumatoid arthritis, and 25 (7.9%) with psoriatic arthritis. Evaluation of the patients' viral serologies revealed that four (1.2%) were HBsAg positive, and 18 (5.7%) were HBsAg negative and HBcAb positive. Anti-HCV positivity was observed in one (0.3%) patient. All serologies were negative in 153 (48.4%) patients. No HBVr was detected during the follow-up of the patients. Conclusion: The rate of resolved hepatitis B infection is relatively high in patients under rheumatologic follow-up. However, the use of biologics in these patients poses a low risk of HBVr.

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Bu Makaleye Atıf Yap

Çırakoğlu, D., Yılmaz, E. S. (2024). Prevalence of Hepatitis B Serology and Reactivation in Rheumatology Patients Receiving Biologic or Targeted Synthetic Disease-Modifying Antirheumatic Drugs. Medical Records, Cilt: 6 Sayı: 3, 542–545. https://doi.org/10.37990/medr.1530674

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