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Dergiler / Medical Records / 2026 / Sayı: 1

Gilaburu (Viburnum Opulus L.) Meyve Ekstraktının Diyabetik Sıçanlarda Dalak Histofizyolojisi Üzerine Etkileri

Effects of Viburnum Opulus L. Fruit Extract on Spleen Histopathology in Diabetic Rats

Selim Demirtaş(MARDİN ARTUKLU ÜNİVERSİTESİ)0000-0001-7249-3092
Gül Şahika Gökdemir(MARDİN ARTUKLU ÜNİVERSİTESİ)0000-0002-8691-1504
Sayfa
—
Yayın Tarihi
2026-02-01
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bulgular: Diyabet grubunda dalak dokusunda beyaz pulpa atrofisi ve kırmızı pulpada aktivasyon artışı gözlenirken, Gilaburu tedavi grubunda anlamlı olarak iyileşme gözlendi.

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Amaç & Hipotez:Giriş: Bu çalışmanın amacı gilaburu (Viburnum opulus L.) ekstraktının diyabetin dalak dokusu üzerindeki olumsuz etkilerine karşı koruyucu ve tedavi edici potansiyelini değerlendirmektir.
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Temel Bulgular & Veri:Diyabet ve tedavi gruplarına 50 mg/kg streptozotosin uygulandı.
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Sonuç & Katkı:Bulgular: Diyabet grubunda dalak dokusunda beyaz pulpa atrofisi ve kırmızı pulpada aktivasyon artışı gözlenirken, Gilaburu tedavi grubunda anlamlı olarak iyileşme gözlendi.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Viburnum · Diabetes Mellitus · Dalak

Özet

Giriş: Bu çalışmanın amacı gilaburu (Viburnum opulus L.) ekstraktının diyabetin dalak dokusu üzerindeki olumsuz etkilerine karşı koruyucu ve tedavi edici potansiyelini değerlendirmektir. Gereç ve Yöntemler: Deneysel çalışmada sıçanlar kontrol, diyabet ve tedavi grupları olmak üzere üç gruba ayrıldı. Diyabet ve tedavi gruplarına 50 mg/kg streptozotosin uygulandı. Ek olarak, tedavi grubuna 200 mg/kg gilaburu ekstresi uygulandı. Hayvanlar sakrifiye edildi ve dalak dokuları histopatolojik analiz için ayrıldı. Dokular Hematoksilen-Eozin ve Masson trikrom boyama yöntemleri ile değerlendirildi. Bulgular: Diyabet grubunda dalak dokusunda beyaz pulpa atrofisi ve kırmızı pulpada aktivasyon artışı gözlenirken, Gilaburu tedavi grubunda anlamlı olarak iyileşme gözlendi. Masson trikrom boyamada, bağ dokusundaki fibrozis miktarının azaldığı ve doku yapısının iyileştiği gözlendi. Sonuç: Gilaburu ekstresinin dalak dokusunda diyabetin neden olduğu histopatolojik değişikliklere karşı koruyucu ve iyileştirici etkileri olduğu belirlenmiştir. Elde edilen veriler gilaburu ekstresinin diğer bitkisel tedavi yöntemlerine benzer olumlu etkiler sağladığını düşündürmektedir. Bu çalışma, diyabete bağlı organ hasarına karşı bitkisel tedavi yaklaşımlarının potansiyel olumlu etkilerini ortaya koymaktadır.

Abstract

Aim: We aimed to evaluate the protective and therapeutic potential of guelder rose (GR) extract against adverse effects of diabetes on spleen tissue in this research. Material and Method: Animals were divided into three groups: control, diabetes and treatment groups. Diabetes and treatment groups were induced with 50 mg/kg streptozotocin (STZ). In addition, the treatment group received 200 mg/kg of GR extract. Animals were sacrificed and spleen tissues were separated for histopathologic analysis. The tissues were evaluated by Hematoxylin-Eosin (H&E) and Masson trichrome staining methods. Results: It was confirmed histologically that diabetic rats developed a decrease in white pulp volume and red pulp hyperactivity in the spleen, but these degenerative processes regressed in individuals given GR extract. Masson trichrome staining showed that the amount of fibrosis in the connective tissue decreased and the tissue structure improved. Conclusion: It was determined that GR extract has protective and healing effects against histopathological changes caused by diabetes in the spleen tissue. The obtained data suggest that GR extract provides similar positive effects to other herbal treatment methods. This study demonstrates the potential positive effects of herbal therapeutic approaches against organ damage due to diabetes.

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Bu Makaleye Atıf Yap

Demirtaş, S., Gökdemir, G. Ş. (2026). Gilaburu (Viburnum Opulus L.) Meyve Ekstraktının Diyabetik Sıçanlarda Dalak Histofizyolojisi Üzerine Etkileri. Medical Records, Sayı: 1. https://doi.org/10.37990/medr.1672043

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