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Dergiler / International Journal of Health Services Research and Policy / 2020 / Volume: 5 Issue: 3

ADHERENCE TO PROPHYLAXIS IN RELATION TO QUALITY OF LIFE AND ANXIETY LEVEL IN TURKISH PATIENTS WITH SEVERE HAEMOPHILIA A

Zühre Kaya(Gazi University, Department of Paediatrics, Paediatric Haematology Unit, Haemostasis Laboratory, Ankara, Turkey)0000-0002-3798-7246
Serap Kirkiz(Gazi University, Faculty of Medicine, Department of Paediatrics, Paediatric Haematology Unit, Ankara, Turkey)0000-0002-3885-5325
Meryem Albayrak(Kirikkale University, Faculty of Medicine, Department of Paediatrics, Paediatric Hematology Unit, Kırıkkale, Turkey)0000-0003-2711-5150
Esra Güney(Gazi University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Ankara, Turkey)0000-0002-4043-8301
Selin Aytac(Hacettepe University, Faculty of Medicine, Department of Paediatrics, Paediatric Haematology Unit, Ankara, Turkey)0000-0003-2192-298X
Namık Yaşar Özbek(University of Health Sciences Ankara Child Health Diseases Hematology-Oncology Training and Research Hospital, Ankara, Turkey)0000-0001-6857-0681
Sayfa
—
Yayın Tarihi
2020-12-25
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Pharmacokinetic-guided prophylaxis for adults and home treatment for children in haemophilia A would enhance adherence to prophylaxis, increase QoL and reduce anxiety levels.

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Amaç & Hipotez:Background: Bleeding increases anxiety and reduces quality of life (QoL) for patients with severe haemophilia A.
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Temel Bulgular & Veri:Methods: Forty-three patients with severe haemophilia A were stratified into three groups by age: 12 children aged 2-13 years, 17 adolescents aged 14-21 years, and 14 adults aged 21-65 years.
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Sonuç & Katkı:Conclusion: Pharmacokinetic-guided prophylaxis for adults and home treatment for children in haemophilia A would enhance adherence to prophylaxis, increase QoL and reduce anxiety levels.
🔬Tür:Uygulamalı Anket & Alan Araştırması
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Prophylaxis · adherence · quality of life

Abstract

Background: Bleeding increases anxiety and reduces quality of life (QoL) for patients with severe haemophilia A. This study investigated adherence to prophylaxis in relation to QoL and anxiety level in haemophilia A patients. Methods: Forty-three patients with severe haemophilia A were stratified into three groups by age: 12 children aged 2-13 years, 17 adolescents aged 14-21 years, and 14 adults aged 21-65 years. Quality of life and anxiety level were assessed using the 36-item Short Form Health Survey (SF-36) and the State-Trait Anxiety Inventory (STAI), respectively. Regular prophylaxis (RP) and pharmacokinetic (PK)-guided prophylaxis were prescribed for 30 and 13 patients, respectively. Results: All the children (n=12; nine RP, three PK-guided prophylaxis) and 10 (58.8%, PK-guided prophylaxis) of the adolescents were completely adherent to prophylaxis. Seven (41.2%) of the adolescents and all 14 adults (100%) were non-adherent to prophylaxis. Compared to findings for the adolescents, anxiety level was higher among the children’s parents and among the adults (p<0.05 for both). The QoL level was lower for the adults than for the parents of children and for the adolescents (p<0.05 for both). Conclusion: Pharmacokinetic-guided prophylaxis for adults and home treatment for children in haemophilia A would enhance adherence to prophylaxis, increase QoL and reduce anxiety levels.

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Bu Makaleye Atıf Yap

Kaya, Z., Kirkiz, S., Albayrak, M., Güney, E., Aytac, S., Özbek, N. Y. (2020). ADHERENCE TO PROPHYLAXIS IN RELATION TO QUALITY OF LIFE AND ANXIETY LEVEL IN TURKISH PATIENTS WITH SEVERE HAEMOPHILIA A. International Journal of Health Services Research and Policy, Volume: 5 Issue: 3. https://doi.org/10.33457/ijhsrp.738665

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Kaynakça (25)

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