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Dergiler / International Journal of Chemistry and Technology / 2026 / Volume: 6 Issue: 1

Benzoik asit halkali yeni hibrit kalkonlarin sentezi ve biyolojik aktiviteleri

Synthesis and biological activities of new hybrid chalcones with benzoic acid ring

Bedriye Seda Kurşun Aktar(çankırı karatekin üniversitesi)0000-0002-1492-3266
Yusuf Sıcak(MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ, KÖYCEĞİZ MESLEK YÜKSEKOKULU)0000-0003-2339-5837
Emine Elçin Oruç-emre(GAZİANTEP ÜNİVERSİTESİ, FEN-EDEBİYAT FAKÜLTESİ, KİMYA BÖLÜMÜ, KİMYA PR.)0000-0001-6840-9660
Sayfa
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Yayın Tarihi
2022-07-06
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.

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Amaç & Hipotez:A series of E-4-(3-oxo-3-(substituted)prop-1-en-1-yl)benzoic acid derivatives (1-5) were synthesized by the Claisen-Schmidt condensation of various ketones with 4-formylbenzoic acid.
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Temel Bulgular & Veri:The anticholinesterase (AChE and BChE), tyrosinase, and urease inhibition activities of the synthesized compounds (1-5) were examined.
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Sonuç & Katkı:Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Chalcone · Anticholinesterase activity · Tyrosinase inhibitory activity

Abstract

A series of E-4-(3-oxo-3-(substituted)prop-1-en-1-yl)benzoic acid derivatives (1-5) were synthesized by the Claisen-Schmidt condensation of various ketones with 4-formylbenzoic acid. The anticholinesterase (AChE and BChE), tyrosinase, and urease inhibition activities of the synthesized compounds (1-5) were examined. It was found that the most active compound against AChE enzyme in anticholinesterase inhibition activity was compound 1. Compound 4 was the most active compound in tyrosinase inhibition activity, while compound 3 was the most active compound in urease psychological activity.

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Bu Makaleye Atıf Yap

Aktar, B. S. K., Sıcak, Y., Oruç-emre, E. E. (2022). Benzoik asit halkali yeni hibrit kalkonlarin sentezi ve biyolojik aktiviteleri. International Journal of Chemistry and Technology, Volume: 6 Issue: 1. https://doi.org/10.32571/ijct.1003871

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Kaynakça (57)

  1. Ağalar, H.G. Pharmacognostical Investigations on Arum italicum Miller. Ph.D. Dissertation, Anadolu University, Eskişehir, 2016.
  2. Hartman, R.E. Actions of bioactive phytochemicals in cell function and Alzheimer’s Disease pathology. L. Packer, H. Sies, M. Eggersdorfer, E. Cadenas Ed.; Cadenas Micronutrients and Brain Health. 2009; pp 225. CRC Press.
  3. Kuşman, K. Isolation of bioactive glaucine and other alkaloids from some glaucium species grown in Turkey and quantification with high performance liquid chromatography. Ph.D. Dissertation, İstanbul University, İstanbul, 2018.
  4. I. Parveen, M.D; Threadgill, J.M; Moorby, A. J Agric Food Chem, 2010, 58, 1371-1382.
  5. Sıcak, Y.; Büyüksakallı, H.; Malkoçoğlu, S.; Özler, M. A.; Öztürk, M. J. Ong. Chem. Res., 2017, 3(1), 22-31.
  6. Kim, Y.J.; Uyama, H. Cell Mol. Life Sci. 2005, 62, 1707-1723.
  7. Modolo, L.V.; Souza, A.X.; Horta, L.P.; Araujo, D.P.; Fátima, A. J. Adv. Res. 2015, 6, 35-44.
  8. Sıcak, Y.; Nadeem, S.; Aktar, B. S. K.; Emre, E. E. O.; Öztürk, M.; İyidoğan, A. K.; Demirtaş, İ. J. Ong. Chem. Res. 2017, 3(1), 32-49.
  9. Dimmock, J.R.; Elias, D. W.; Beazely, M. A.; Kandepu, N. M. Bioactivities of chalcones, Curr. Med. Chem. 1999, 6, 1125-1149.
  10. Detsi, A.; Majdalani, M.; Kontogiorgis, C.A.; Hadjipavlou-Litin, D.; Kefalas, P. Bioorg. Med. Chem. 2009, 17, 8073-8085.
  11. Kurşun-Aktar, B. S.; Oruç-Emre, E. E.; Karaküçük-İyi̇doğan, A., Yağlioğlu, A. Ş.; Demi̇rtaş, İ.; Teki̇n, Ş. J. Res. Pharm. 2017, 21(4), 949-960.
  12. Fringuelli, F.; Pizzo, F.; Vittoriani, C.; Vaccacio, L. Chem. Comm. 2004, 23, 2756-2757.
  13. Selepe, M.A.; Heerden, F.R.V. Molecules. 2013, 18, 4739-4765.
  14. Xu, L.; Li, L.; Xia, C.; Zhao, P. Helv. Chim. Acta. 2014, 87, 3080-3084.
  15. Wu, X.F.; Neumann, H.; Spannenberg, A.; Schulz, T.; Jiao, H.J.; Beller, M. J. Am. Chem. Soc. 2010, 132, 14596-14602.
  16. Chen, M. S.; Christensen, B.; Blom, J.; Lemmich, E.; Nadelmann, L.; Fich, K.; Theander, T. G.; Kharazmi, A.; Licochalcone A. Antimicrob. Agents Chemother. 1993, 37, 2550-2556.
  17. Kakati, D.; Sarma, J.C. Chem. Cent. 2011, 5, 8.
  18. Rueping, M.; Bootwicha, T.; Baars, H.; Sugiono, E.Beilstein J. Org. Chem. 2011, 7, 1680-1687.
  19. Schramm, O.G. Multi-component Heterocycle Syntheses Based upon Sonogashira Coupling Isomerization (Dissertation), Ruprecht-Karls University, Heidelberg, Germany, 2006.
  20. Bukhari, S. N. A.; Butt, A.M.; Amjad, M.W.; Ahmad, B. A.; Shah, V.H.; Trivedi A.R. Pak. J.Pharm. Sci. 2013,16, 1368-1372.
  21. Kumar, A.; Sharma, S.; Tripathi, V.D.; Srivastava, S. Tetrahedron. 2010, 66, 9445-9449.
  22. Zhao, L.; Jin, H.; Sun, L.; Piao, H.; Quan, Z. Bioorg. Med. Chem Lett. 2005, 15, 5027-5029.
  23. Mahapatra, D.K.; Asati, V.; Bharti, S.K. Eur. J. Med. Chem. 2015,92, 839-865.
  24. Zhang, B.; Lai, Y.; Li, Y.; Shu, N.; Wang, Y.; Li, Y.; Chen, Z. Eur. J. Pharmacol. 2018, 57-67.
  25. Lee, Y. S.; Lim, S. S.; Shin, K. H.; Ohuchi, Y. S. K.; Jung, S. H. Biol. Pharm. Bul. 2006, 29, 1028-1031.
  26. Rizvi, S. U. F.; Siddiqui, H. L.; Johns, M.; Detorio, M.; Schinazi. R. F. Med. Chem. Res. 2012, 21, 3741-3749.
  27. Israf, D. A.; Khaizurin, T. A.; Syahida, A.; Lajis, N. H.; Khozirah, S.Mol. Immunol. 2007, 44, 673-679.
  28. Kim, D. W.; Curtis-Long, M. J.; Yuk, H. J.; Wang, Y.; Song, Y. H.; Jeong, S. H.; Park, K. H. 2014, Food Chem. 153, 20-27.
  29. Yamamoto, T.; Yoshimura, M.; Yamaguchi, F.; Kouchi, T.; Tsuji, R.; Saito, M.; Obata, A.; Kikuchi, M. Biosci. Biotechnol. Biochem. 2004, 68, 1706-1711.
  30. Aoki, N.; Muko, M.; Ohta, E.; Ohta, S. J. Nat. Prod. 2008, 71, 1308-1310.
  31. Birari, R. B.; Gupta, S.; Mohan, C. G.; Bhutani, K. K. Phytomedicine. 2011, 18, 795- 801.
  32. Sashidhara, K.V.; Palnati, G. R.; Sonkar, R.; Avula, S. R.; Awasthi, C.; Bhatia, G. 2013, Eur. J. Med. Chem, 64, 422-431.
  33. Mascarello, A.; Chiaradia, L. D.; Vernal, J.; Villarino, A.; Guido, R. V.; Perizzolo, P.; Poirier, V.; Wong, D.; Martins, P. G.; Nunes, R. J.; Yunes, R. A.; Andricopulo, A. D.; Av-Gay, Y.; Terenzi, H. Bioorg. Med. Chem. 2010, 18, 3783-3789.
  34. Sashidhara, K.V.; Rao, K.B.; Kushwaha, V.; Modukuri, R.K.; Verma, R.; Murthy, P.K. Eur. J. Med. Chem. 2014, 81, 473-480.
  35. Wang, M.; Xu, S.; Wu, C.; Liu, X.; Tao, H.; Huang, Y.; Liu, Y.; Zheng, P.; Zhu, W. 2016, Bioorg. Med. Chem Lett. 26, 5450–5454.
  36. Tomar, V.; Bhattacharjee, G.; Rajakumar, S.; Srivastava,K.; Puri, S.K. 2010, Eur. J. Med. Chem. 45, 745-751.
  37. Abdullah, M. I.; Mahmood, A.; Madni, M.; Masood, S.; Kashif, M. Bioorg. Chem. 2014, 54, 31-37.
  38. Lahtchev, K. V.; Batovska, D. I.; Parushev, S. P.; Ubiyvovk, V. M.; Sibirny, A. A. Eur. J. Med. Chem. 2008, 43, 2220-2228.
  39. Sashidhara, K.V.; Avula, S.R.; Mishra, V.; Palnati, G.R.; Singh, L.R.; Singh, N.; Chhonker, Y.S.; Swamy, P.; Bhatta, R.S.; Palit, G. Eur. J. Med. Chem, 2015, 89, 638-653.
  40. Bail, J.L.; Pouget, C.; Fagnere, C.; Basly, J.; Chulia, A.; Habrioux, G. Life Sci. 2001, 68, 751-761.
  41. Luo, Y.; Song, R.; Li, Y.; Zhang, S.; Liu, Z.J.; Fu, J.; Zhu, H.L. Bioorg. Med. Chem Lett. 2012, 22, 3039-3043
  42. Cho, S.; Kim, S.; Jin, Z.; Yang, H.; Han, D. N.; Baek, I.; Jo, J.; Cho, C.W.; Park, J.H.; Shimizu, M.; Jin, Y.H.Biochem. Biophys. Res. Commun. 2011, 413, 637-642.
  43. Jamal, H.; Ansari, W.H.; Rizvi, S.J. Fund. Clin. Pharmacol. 2008, 22, 673-681.
  44. Sato, Y.; He, J.; Nagai, H.; Tani, T.; Akao, T. Biol. Pharm. Bull. 2007, 30, 145-149.
  45. Campos-Buzzi, F.; Padaratz, P.; Meira, A.V.; Correa, R.; Nunes, R. J.; CechinelFilho, V. Molecules. 2007, 12, 896-906.
  46. Ortolan, X.R.; Fenner, B.P.; Mezadri, T.J.; Tames, D.R.; Correa, R.; Campos Buzzi, F. Craniomaxillofacial surgery. 2014, 42, 520-524.
  47. Kursun Aktar, B.S.; Oruç-Emre, E.E.; Demirtas¸ I., Sahin Yaglioglu, A.; Guler, C.; Adem, S.; Karaküçük Iyidogan, A. J. Mol. Struct. 2017, 1149, 632-639.
  48. Tao, X. X.; Duan, Y. T.; Chen, L. W.; Tang, D. J.; Yang, M. R.; Wang, P. F.; Xu, C.; Zhu, H. L. Bioorg. Med. Chem Lett. 2016, 677-683.
  49. Ellan, G.L.; Courtney, K.D.; Andres, V.; Featherstone, R.M. Biochem Pharmacol Behaivor, 1961, 7, 88-95.
  50. Hearing, V. J. Methods in Enzymology. Academic Press: New York, 1987, 142: 154-165.
  51. Weaterburn, M.W. Analy Chem. 1967, 39: 971-974.
  52. Daina,A.; Michielin, O.; Zoete, V. Scientific Reports, 2017, 7(), 42717.
  53. Molsoft molecules in silico. http://moloft.com/mprop (accessed September 9, 2021)
  54. Sıcak Y. Med. Chem. Res. 2021, 30(8), 1557-1568.
  55. Sıcak, Y. Turk J Chem. 2021, DOI: 10.3906/kim-2107-27
  56. Wu, X.F.; Neumann, H.; Spannenberg, A.; Schulz, T.; Jiao, H.J.; Beller, M. J. Am. Chem. Soc. 2010, 132, 14596-14602.
  57. Bukhari, S. N. A.; Butt, A.M.; Amjad, M.W.; Ahmad, B. A.; Shah, V.H.; Trivedi A.R. Pak. J.Pharm. Sci. 2013,16, 1368-1372.