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Dergiler / Current Perspectives on Medicinal and Aromatic Plants / 2020 / Volume: 3 Issue: 2

Amelioration of External Surgical Wound by Topical Application of the Aqueous Formulation of Neem Leaves (Azadirachta indica) in Caprine Model

Ajmary Sultana(Bangladesh Agricultural University)0000-0003-3617-3985
Marzia Rahman(Bangladesh Agricultural University)0000-0002-8646-3246
Md. Mahmudul Alam(Department of Surgery and Obstetrics, Bangladesh Agricultural University, Faculty of Veterinary Science, Mymensingh, Bangladesh)0000-0002-3464-4125
Sayfa
—
Yayın Tarihi
2020-12-24
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Thus, the present study supports the scientific rationale for the use of Neem leaf in the management of wounds.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The study was conducted to evaluate the healing potentials of Neem leaf on surgical wounds.
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Temel Bulgular & Veri:We have found a remarkably lower swollen area (3.91±0.10mm), suture line levation (2.64±0.19mm) and length of the wound (15.78±0.19mm) in the treatment group than the control (0.36±0.12mm, 3.59±0.12mm, and 17.11±0.08mm respectively).
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Sonuç & Katkı:Thus, the present study supports the scientific rationale for the use of Neem leaf in the management of wounds.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Neem leaf · Surgical wound · Histopathology

Abstract

The study was conducted to evaluate the healing potentials of Neem leaf on surgical wounds. A total of sixteen surgical wounds were studied under two groups; Neem (group A) and Normal saline (group B, control). Wound morphology, histopathology, and bacteriological examinations were carried out to assess wound healing potentials of this plant leaves. We have found a remarkably lower swollen area (3.91±0.10mm), suture line levation (2.64±0.19mm) and length of the wound (15.78±0.19mm) in the treatment group than the control (0.36±0.12mm, 3.59±0.12mm, and 17.11±0.08mm respectively). The mean healing period Neem treated wound was significantly (P<0.05) lower (12.33±0.42 days) than that of control (18.67±0.33 days). Histopathological study revealed the presence of substantial inflammation with fibroblastic proliferation in samples collected at day 3 in the control group whereas these features were distinctly reduced in the treatment group. There was a distinct thickening of the keratinized layer of the epidermis in Neem treated wound on day 21. In bacteriological study, huge bacterial colonies were found on day 3 in the control group whereas this was markedly reduced in number in the wound of Group-A. Thus, the present study supports the scientific rationale for the use of Neem leaf in the management of wounds.

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Bu Makaleye Atıf Yap

Sultana, A., Rahman, M., Alam, M. M. (2020). Amelioration of External Surgical Wound by Topical Application of the Aqueous Formulation of Neem Leaves (Azadirachta indica) in Caprine Model. Current Perspectives on Medicinal and Aromatic Plants, Volume: 3 Issue: 2. https://doi.org/10.38093/cupmap.828751

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Kaynakça (21)

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