KaydedilenlerDerginizi ekleyin

Dergiler / Current Perspectives on Medicinal and Aromatic Plants / 2026 / Volume: 9

Investigation of Anti-Inflammatory Properties and Phytochemical Profiling of Two Galls Extracts from Pistacia terebinthus: Implications for Therapeutic Applications

Bellifa Nazım(University Djilali Liabes SIDI BEL ABBES)0000-0002-4247-1850
Oughılas Ahmed(Djillali Liabes University of Sidi-Bel-Abbes)0009-0007-3240-0788
Amel Helalı(university of Tlemcen)0000-0002-0421-1046
Benhaddou Ismaıl(Djillali Liabes University of Sidi-Bel-Abbes)0000-0002-6322-5907
Merad Yassine0000-0001-5671-684X
Sayfa
—
Yayın Tarihi
2026-09-08
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

This is comparable to the anti-inflammatory activity of diclofenac sodium, a standard anti-inflammatory drug and confirm the traditional use of galls and may offer a promising natural therapeutic approach for inflammatory diseases.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:The passage discusses the historical use of Pistacia terebinthus L. galls in traditional medicine, highlighting their diverse applications such as in medicines, dyes, ink, and soap.
📊
Temel Bulgular & Veri:High-performance liquid chromatography (HPLC) analysis showed a clear difference in the phenolic composition of the two types of galls extract The MeOH extract of the galls was predominantly dominated by phenolic acids, mainly hydroxycinnamic acids, caffeic acid, caffeoylquinic acid, and chlorogenic acid and tannin.
💡
Sonuç & Katkı:This is comparable to the anti-inflammatory activity of diclofenac sodium, a standard anti-inflammatory drug and confirm the traditional use of galls and may offer a promising natural therapeutic approach for inflammatory diseases.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:antinflammatory · gall · Pistacia terebinthus

Abstract

The passage discusses the historical use of Pistacia terebinthus L. galls in traditional medicine, highlighting their diverse applications such as in medicines, dyes, ink, and soap. Despite their long history of use, limited research has compared the chemical composition and anti-inflammatory properties of different types of these galls. This study aimed to fill this gap by characterizing the chemical composition of Pistacia terebinthus L. galls and evaluating their anti-inflammatory activity. Galls were collected, processed, and subjected to phytochemical analysis, revealing a rich presence of bioactive compounds, particularly phenolic acids. High-performance liquid chromatography (HPLC) analysis showed a clear difference in the phenolic composition of the two types of galls extract The MeOH extract of the galls was predominantly dominated by phenolic acids, mainly hydroxycinnamic acids, caffeic acid, caffeoylquinic acid, and chlorogenic acid and tannin. The results of the inhibition assay indicate that the extract of galls has anti-inflammatory activity. The extract was able to inhibit the denaturation of BSA by 50% at a concentration of 100 μg/ml. This is comparable to the anti-inflammatory activity of diclofenac sodium, a standard anti-inflammatory drug and confirm the traditional use of galls and may offer a promising natural therapeutic approach for inflammatory diseases.

🔖

Bu Makaleye Atıf Yap

Nazım, B., Ahmed, O., Helalı, A., Ismaıl, B., Yassine, M. (2026). Investigation of Anti-Inflammatory Properties and Phytochemical Profiling of Two Galls Extracts from Pistacia terebinthus: Implications for Therapeutic Applications. Current Perspectives on Medicinal and Aromatic Plants, Volume: 9. https://doi.org/10.38093/cupmap.1959214

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (45)

  1. Alma, M. H., Nitz, S., Kollmannsberger, H., Digrak, M., Efe, F. T., & Yilmaz, N. 2004. Chemical composition and antimicrobial activity of the essential oils from the gum of Turkish pistachio (Pistacia vera L.) Agric. Food Chem. 52(12):3911-3914. https://doi.org/10.1021/ jf040014e
  2. Álvarez, R., Martinez, J.-J., Muñoz-Viveros, A. L., Molist, P., Abad-González, J., & Nieto Nafria, J. M. 2016. Contribution of gall micro-scopic structure to taxonomy of gallicolous aphids on Pistacia. Plant Biol. 18(5):868-875. https://doi.org/10.1111/plb.12475
  3. Bakirel, T., CSener, S., Bakirel, U., Kelecs, O., CSennazli, G., & Gürel, A. 2003. Tavanlarda deneysel hiperkolesterolemi ve arterio skleroz üzerine menengicin etkisi. Turk. J. Vet. Sci. 27:1283-1292.
  4. Banc R, Rusu ME, Filip L, Popa D-S. 2023. Phytochemical Profiling and Biological Activities of Quercus sp. Galls (Oak Galls): A Systematic Review of Studies Published in the Last 5 Years. Plants 12(22):3873. https://doi.org/10.3390/plants12223873
  5. Bellakhdar 1997. Pharm. Maroc. Trad. Médicine Arabe Ancienne et Savoirs Populaires, Paris, Ibis Press p189. https://agris.fao.org/search /en/providers/122535/records/65ddf3ce63b8185d9ca5e763
  6. Blackman, R. L., & Eastop, V. F. 1994. Aphids on the world's trees. An identification and information guide. CAB International. NHM, University Press, Cambridge. https://doi.org/ 10.1016/0261-2194(96)89825-5
  7. Blackman, R. L., & Eastop, V. F. 2008. Aphids on the World's Herbaceous Plants and Shrubs, Wiley & Sons,. Chichester, 2006, 2 volume set, 1460. https://www.eje.cz/pdfs/eje/2008/ 01/24.pdf
  8. Bozorgi, M., Memariani, Z., Mobli, M., Salehi Surmaghi, M. H., Shams-Ardekani, M. R., & Rahimi, R. 2013. Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): A Review of Their Traditional Uses, Phytochemistry, and Pharmacology. Sci. World J. 2013:219815. https://doi.org/10.1155/2013 /219815
  9. Bruneton Jean. 2009. Pharmacognosie, phytochimie, plantes médicinales (4e ed.). Lavoisier. https://e.lavoisier.fr/store/page/ 142/comment-recuperer-et-lire-mon-ebook
  10. Brown, J. H., & Mackey, H. K. 1968. Inhibition of heat-induced denaturation of serum proteins by mixtures of nonsteroidal anti-inflammatory agents and amino acids. Proc. Soc. Exp. Biol. Med. 128(1):225-228. https://doi.org/10.3181 /00379727-128-32984
  11. Bukovac, V., Strlivc, M., & Koivcar, D. 2009. Comparison of Methods for Determination of Polyphenols in Wine by HPLC-UV/VIS, LC/MS/MS and Spectrophotometry.Acta Chim. Slov. 56:698-703. https://acta-arhiv.chem-soc.si/56/56-03-698.pdf
  12. Cappers, R. T. J. 2016. Digital atlas of traditional agricultural practices and food processing, Gronijen Libarary ISBN 13: 9789492444004 - Barkhuis. https://research.rug.nl/en/ publications/digital-atlas-of-traditional-agricultural-practices-and-food-proc/
  13. Cortes, D. (2017). Metabolitos Secundarios Activos: Los Medi-camentos Que Nos Proporciona la Naturaleza. ISBN: 9781982044671. https://bibliobuscador.uah. es/discovery/fulldisplay/alma991002883999704214/34UAH_INST:34UAH_VU1
  14. Couladis, M., Özcan, M., Tzakou, O., & Akgül, A. 2003. Comparative essential oil composition of various parts of the turpentine tree (Pistacia terebinthus L) growing wild in Turkey. J. Sci. Food Agric. 83(2):136-138. https://doi.org/ 10.1002/jsfa.1295
  15. Courchet, L. D. J, 1878. Étude sur le groupe des aphides et en particulier sur les pucerons du térébinthe & du lentisque. 57 p., 3 plates, Montpellier. (DOI non disponible – ouvrage ancien)
  16. Dahmoune, F., Boulekbache, L., Moussi, K., Aoun, O., Spigno, G., & Madani, K. 2013. Valorization of Citrus limon residues for the recovery of antioxidants: evaluation and optimization of microwave and ultrasound application to solvent extraction. Ind. Crops Prod. 50:77-87. https://doi.org/10.1016/ j.indcrop.2013.07.013
  17. Denoël, A. 1958. Matière médicale végétale:(Pharamacognosie). Presses Universitaires de Liège. https://www. ethnopharmacologia.org/bibliotheque-ethnopharmacologie/abrege-de-matiere-medicale-matieres-premieres-d-origine-vegetale/
  18. Duru, M. E., Cakir, A., Kordali, S., Zengin, H., Harmandar, M., Izumi, S., & Hirata, T. 2003. Chemical composition and antifungal properties of essential oils of three Pistacia species. Fitoterapia 74(1):170-176. https://doi.org/10.1016/S0367-326X(02) 00318-0
  19. Eshwarappa, R. S. B., Lakshmikantha, R. Y., Subaramaihha, S. R., Subbaiah, S. G. P., Surendranath, A. R., & Dhananjaya, B. L. 2015. Antioxidant activity of insect gall extracts of Pistacia integerrima. Acta Scientiarum Polonorum. Acta Sci. Pol. Technol. Aliment. 14(4):367-374. https://doi.org/10.17306/ J.AFS.2015.4.36
  20. Evans, W. C. 2009. Trease and Evans' pharmacognosy. Elsevier Health Sciences. https://doi.org/10.1016/B978-0-7020-2933-2.X0001-9
  21. Fernández, A., Camacho, A., Fernández, C., Altarejos, J., & Pérez, P. 2000. Composition of the Essential Oils from Galls and Aerial Parts of Pistacia lentiscus L. J. Essent. Oil Res. 12(1):19-23. https://doi.org/10.1080/10412905.2000. 9712031
  22. Giner-Larza, E. M., Máñez, S., Recio, M. C., Giner, R. M., Prieto, J. M., Cerdá-Nicolás, M., & Ríos, J. L. 2001. Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.Eur. J. Pharmacol. 428(1):137-143. https://doi.org/10.1016/S0014-2999(01) 01290-0
  23. Harborne, A. J. 1998. Phytochemical Methods A Guide to Modern Techniques of Plant Analysis. 5th Edition, Chapman and Hall Ltd, London, 21-72. https://doi.org/10.1007/978-94-009-5570-7
  24. Harris, M. O., Stuart, J. J., Mohan, M., Nair, S., Lamb, R. J., & Rohfritsch, O. 2003. Grasses and gall midges: plant defense and insect adaptation.Annu. Rev. Entomol. 48:549-577. https://doi.org/10.1146/annurev.ento.48.091801.112559
  25. Huang, M.-Y., Huang, W.-D., Chou, H.-M., Chen, C.-C., Chen, P.-J., Chang, Y.-T., & Yang, C.-M. 2015. Structural, biochemical, and physiological characterization of photosynthesis in leaf-derived cup-shaped galls on Litsea acuminata. BMC Plant Biol. 15(1):61. https://doi.org/10.1186/s12870-015-0446-0
  26. Kavak, D. D., Altiok, E., Bayraktar, O., & Ülkü, S. 2010. Pistacia terebinthus extract: As a potential antioxidant, antimicrobial and possible β-glucuronidase inhibitor. J. Mol. Catal. B Enzymatic 64(3–4):167-171. https://doi.org /10.1016/j.molcatb.2010.01.029 27. Khare, C. P. 2004. Indian Herbal Remedies: Rational Western Therapy, Ayurvedic, and Other Traditional Usage, Botany. de Khare, C.P.: ISBN: 9783642622298. https://doi.org/10. 1007/978-3-642-18659-2
  27. Kim, D.-O., Chun, O. K., Kim, Y. J., Moon, H.-Y., & Lee, C. Y. 2003. Quantification of polyphenolics and their antioxidant capacity in fresh plums. Fitoterapia 76(1):62-66. https://doi.org/10. 1021/jf0343074
  28. Kivçak, B, & Akay, S. 2005. Quantitative determination of α-tocopherol in Pistacia lentiscus, Pistacia lentiscus var. chia, and Pistacia terebinthus L by TLC-densitometry and colorimetry. Pharm. Biol. 42(4–5):360-366. https://doi.org/10.1016/j.fitote.2004.09.021
  29. Lapie, G., & Maige, A. (1914). Flore forestière illustrée Algérie, Tunisie et Maroc. Paris: E. Orlhac. 648636388-360p. https://doi.org/10. 5962/bhl.title.36748
  30. Luz, F. A., Gonçalves, G. L., Moreira, G. R. P., & Becker, V. O. 2014. Three new cecidogenous species of Palaeomystella Fletcher (Lep-idoptera, Momphidae) from the Brazilian Atlantic Rain Forest. ZooKeys 433:97. https://doi.org/10.3897/zookeys.433.7379
  31. Wichtl Max 2009. Plantes thérapeutiques – Tradition, pratique officinale, science et thérapeutique, (4th ed.; T. and D. Lavoisier, Ed.). https://bibliotheque.univ-catholille.fr/Default/doc/SYRACUSE/294704/plantes-therapeutiques-tradition-pratique-officinale-science-et-therapeutique-4e-ed-allemande-sous-l?_lg=en-US
  32. Orhan, I. E., Senol, F. S., Gulpinar, A. R., Sekeroglu, N., Kartal, M., & Sener, B. 2012. Neuroprotective potential of some terebinth coffee brands and the unprocessed fruits of Pistacia terebinthus L. and their fatty and essential oil analyses. Food Chem. 130(4):882-888. https://doi.org/10.1016/j.foodchem. 2011.07.119
  33. Perrot Perrot, E., Mascré, M., Régnier, J., Crété, P., & Weitz, R. 1943. Matières premières usuelles du règne végétal: thérapeutique, hygiène, industrie. 2 Vol Paris: Masson. https://bibliotheques-specialisees.paris.fr/ark: /73873/pf0001719793
  34. Piras, A., Marzouki, H., Maxia, A., Marengo, A., Porcedda, S., Fal-conieri, D.,Salgueiro, L. 2017. Chemical characterisation and biological activity of leaf essential oils obtained from Pistacia terebinthus growing wild in Tunisia and Sardinia Island. Nat. Prod. Res. 31(22):2684-2689. https://doi.org/10.1080/ 14786419.2017.1289204
  35. Pulaj, B., Mustafa, B., Nelson, K., Quave, C. L., & Hajdari, A. 2016. Chemical composition and in vitro antibacterial activity of Pistacia terebinthus essential oils derived from wild populations in KosovoBMC Complement Altern Med. 16(1):147. https://doi.org/10.1186/ s12906-016-1135-8
  36. Thakur, V., Guleria, R., & Singh, R. 2017. Anti-Inflammatory ac-tivities of metanolic extract of galls of Pistacia integerrima.J. Pharmacognosy Phytochem. 6(6):2144-2146. https://www. phytojournal.com/archives/view-pdf/2344/6-6-259
  37. Topçu, G., Ay, M., Bilici, A., Sarikürkcü, C., Öztürk, M., & Ulubelen, A. 2007. A new flavone from antioxidant extracts of Pistacia terebinthus. Food Chem. 103(3):816-822. https://doi.org/ 10.1016/j.foodchem.2006.09.028
  38. Uhl'iková, H., Obovril, M., Klempová, J., Šedo, O., Zdráhal, Z., Kašparovsk`y, T., Lochman, J. 2016. Elicitin-induced distal systemic resistance in plants is mediated through the protein--protein interactions influenced by selected lysine residues. Front. Plant Sci. 7:59. https://doi.org /10.3389/fpls.2016.00059
  39. Ulukanli, Z., Karabörklü, S., Öztürk, B., Çenet, M., & Balcilar, M. 2014. Chemical composition, antibacterial and insecticidal activities of the essential oil from the Pistacia terebinthus L. Spp. palaestina (Boiss.) (Anacardiaceae). J. Food Process. Preserv. 38(3):815-822. https://doi. org/10.1111/jfpp.12035
  40. Bozorgi, M., Memariani, Z., Mobli, M., Salehi Surmaghi, M. H., Shams-Ardekani, M. R., & Rahimi, R. 2013. Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): A Review of Their Traditional Uses, Phytochemistry, and Pharmacology. Sci. World J. 2013:219815. https://doi.org/10.1155/2013 /219815
  41. Cappers, R. T. J. 2016. Digital atlas of traditional agricultural practices and food processing, Gronijen Libarary ISBN 13: 9789492444004 - Barkhuis. https://research.rug.nl/en/ publications/digital-atlas-of-traditional-agricultural-practices-and-food-proc/
  42. Kavak, D. D., Altiok, E., Bayraktar, O., & Ülkü, S. 2010. Pistacia terebinthus extract: As a potential antioxidant, antimicrobial and possible β-glucuronidase inhibitor. J. Mol. Catal. B Enzymatic 64(3–4):167-171. https://doi.org /10.1016/j.molcatb.2010.01.029 27. Khare, C. P. 2004. Indian Herbal Remedies: Rational Western Therapy, Ayurvedic, and Other Traditional Usage, Botany. de Khare, C.P.: ISBN: 9783642622298. https://doi.org/10. 1007/978-3-642-18659-2
  43. Luz, F. A., Gonçalves, G. L., Moreira, G. R. P., & Becker, V. O. 2014. Three new cecidogenous species of Palaeomystella Fletcher (Lep-idoptera, Momphidae) from the Brazilian Atlantic Rain Forest. ZooKeys 433:97. https://doi.org/10.3897/zookeys.433.7379
  44. Perrot Perrot, E., Mascré, M., Régnier, J., Crété, P., & Weitz, R. 1943. Matières premières usuelles du règne végétal: thérapeutique, hygiène, industrie. 2 Vol Paris: Masson. https://bibliotheques-specialisees.paris.fr/ark: /73873/pf0001719793
  45. Ulukanli, Z., Karabörklü, S., Öztürk, B., Çenet, M., & Balcilar, M. 2014. Chemical composition, antibacterial and insecticidal activities of the essential oil from the Pistacia terebinthus L. Spp. palaestina (Boiss.) (Anacardiaceae). J. Food Process. Preserv. 38(3):815-822. https://doi. org/10.1111/jfpp.12035