KaydedilenlerDerginizi ekleyin

Dergiler / BEYOGLU EYE JOURNAL / 2019 / Cilt: 4 - Sayı: 2

The Optimal Cutoff Value of Neutrophil/Lymphocyte Ratio for Severe Grades of Diabetic Retinopathy

Çağrı İLHAN
Mehmet ÇITIRIK
Mehmet Murat UZEL
Kemal TEKİN
Sayfa
76–81
DOI
—
🏛️Bu makalenin bibliyografik verileri ve tam metin bağlantısı DergiPark üzerinden sağlanmıştır.
DergiPark Kaydı ↗
✨

Yapay Zeka Hızlı Bakış & Çıkarımlar

AI Insight
⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: An NLR value of 2.11 or more predicted DR (PDR or severe NPDR) with a sensitivity of 76% and a speci-ficity of 80%.

📌 3 Maddede Bu Makale

🎯
Amaç & Hipotez:Objectives: The aim of this study was to define the optimal cutoff value of the neutrophil/lymphocyte ratio (NLR) to predict severe grades of diabetic retinopathy (DR).
📊
Temel Bulgular & Veri:Methods: A total of 40 patients with proliferative DR (PDR) and 40 patients with severe non-proliferative DR (NPDR) were included this prospective, case control study, and 35 age- and sex-matched healthy subjects were recruited as a control group.
💡
Sonuç & Katkı:Conclusion: An NLR value of 2.11 or more predicted DR (PDR or severe NPDR) with a sensitivity of 76% and a speci-ficity of 80%.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

Objectives: The aim of this study was to define the optimal cutoff value of the neutrophil/lymphocyte ratio (NLR) to predict severe grades of diabetic retinopathy (DR). Methods: A total of 40 patients with proliferative DR (PDR) and 40 patients with severe non-proliferative DR (NPDR) were included this prospective, case control study, and 35 age- and sex-matched healthy subjects were recruited as a control group. White blood cell (WBC) count mean values and ratios were compared between the groups. Results: The groups were statistically similar in terms of age and sex. The neutrophil, lymphocyte, monocyte, platelet counts, and main platelet volume (MPV) values were similar in all 3 groups (all p values >0.05). The mean NLR was 2.67±1.02 in the PDR cases, 2.16±0.58 in severe NPDR, and 1.85±0.49 in the control group, which represented a statis-tically significant difference between the 3 groups (p=0.003). In post-hoc analysis, the NLR of the PDR and severe NPDR groups was statistically significantly greater than that of the control group (p=0.002 and p=0.048, respectively), but there was no statistically significant difference between the PDR and severe NPDR groups (p=0.083). The monocyte/lympho-cyte, platelet/lymphocyte, and MPV/lymphocyte ratios were also similar in all 3 groups (all p values >0.05). Conclusion: An NLR value of 2.11 or more predicted DR (PDR or severe NPDR) with a sensitivity of 76% and a speci-ficity of 80%.

🔖

Bu Makaleye Atıf Yap

İLHAN, Ç., ÇITIRIK, M., UZEL, M. M., TEKİN, K. (2019). The Optimal Cutoff Value of Neutrophil/Lymphocyte Ratio for Severe Grades of Diabetic Retinopathy. BEYOGLU EYE JOURNAL, Cilt: 4 - Sayı: 2, 76–81. https://ajindex.com/articles/143731

📄 Tam Metin PDF Okuyucu

📄

PDF görüntüleyici hazırlanıyor...

Kaynakça (10)

  1. Mbata O, Abo El-Magd NF, El-Remessy AB. Obesity, metabolic syndrome and diabetic retinopathy: Beyond hyperglycemia. World J Diabetes 2017;8:317–29.
  2. Wong TY, Cheung N, Tay WT, Wang JJ, Aung T, Saw SM, et al. Prevalence and risk factors for diabetic retinopathy: the Singa-pore Malay Eye Study. Ophthalmology 2008;115:1869–75.
  3. Yau JW, Rogers SL, Kawasaki R, Lamoureux EL, Kowalski JW, Bek T, et al; Meta-Analysis for Eye Disease (META-EYE) Study Group. Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care 2012;35:556–64.
  4. Sertoglu E, Uyanik M. Accurate use of neutrophil/lymphocyte ratio from the perspective of laboratory experts. Vasc Health Risk Manag 2014;10:13–4. Núñez J, Núñez E, Bodí V, Sanchis J, Miñana G, Mainar L, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in STsegment elevation myocardial infarc-tion. Am J Cardiol 2008;101:747–52.
  5. Gibson PH, Croal BL, Cuthbertson BH, Small GR, Ifezulike AI, Gibson G, et al. Preoperative neutrophil-lymphocyte ratio and outcome from coronary artery bypass grafting. Am Heart J 2007;154:995–1002.
  6. Valero C, Pardo L, López M, García J, Camacho M, Quer M, et al. Pretreatment count of peripheral neutrophils, monocytes, and lymphocytes as independent prognostic factor in patients with head and neck cancer. Head Neck 2017;39:219–26.
  7. Zhao W, Wu Z, Li Y, Jia H, Chen M, Gu X, et al. Pretreatment neutrophil-to-lymphocyte ratio and its dynamic changes are as-sociated with the overall survival in advanced cancer patients undergoing palliative care. Sci Rep 2016;6:31394. Guthrie GJ, Charles KA, Roxburgh CS, Horgan PG, McMillan DC, Clarke SJ. The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. Crit Rev Oncol Hematol 2013;88:218–30. Kaya MG. Inflammation and coronary artery disease: as a new biomarker neutrophil/lymphocyte ratio. Turk Kardiyol Dern Ars 2013;41:191–2.
  8. Ulu SM, Dogan M, Ahsen A, Altug A, Demir K, Acartürk G, et al. Neutrophil-to-lymphocyte ratio as a quick and reliable pre-dictive marker to diagnose the severity of diabetic retinopathy. Diabetes Technol Ther 2013;15:942–7.
  9. Wilkinson CP, Ferris FL 3rd, Klein RE, Lee PP, Agardh CD, Davis M, et al. Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales. Ophthalmology 2003;110:1677–82.
  10. Celik B, Nalcacioglu H, Ozcatal M, Altuner Torun Y. Role of neu-trophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in iden