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Dergiler / Atmospheric Pollution Research / 2020 / Cilt: 11 - Sayı: 5

Development of a simulation chamber for the evaluation of dermalabsorption of volatile organic compounds

Soraya PONTES-LOPEZ
Julia MORENO
Francesc A. ESTEVE-TURRİLLAS
Sergio ARMENTA
Sayfa
1009–1017
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Different air concentration of BTEX were evaluated in the calibration chamber,indicating thatflux increased proportionally to the BTEX concentration in air and the lag time decreased as theair concentration of BTEX increased.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:An exposition chamber has been designed and developed for the production of contaminated atmospheres withfixed and known concentration of volatile organic compounds.
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Temel Bulgular & Veri:Polydimethylsiloxane (PDMS) and Strat-M®membranes were evaluated, including the effect ofmembrane thickness, from 0.5 to 3.0 mm, on the diffusion parameters.
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Sonuç & Katkı:Different air concentration of BTEX were evaluated in the calibration chamber,indicating thatflux increased proportionally to the BTEX concentration in air and the lag time decreased as theair concentration of BTEX increased.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alan Parametreleri

Özet

An exposition chamber has been designed and developed for the production of contaminated atmospheres withfixed and known concentration of volatile organic compounds. The proposed chamber has been evaluated for thedetermination ofin-vitrodiffusion parameters, such asflux and lag time for benzene, toluene, ethylbenzene, andxylenes (BTEX). Polydimethylsiloxane (PDMS) and Strat-M®membranes were evaluated, including the effect ofmembrane thickness, from 0.5 to 3.0 mm, on the diffusion parameters. The obtainedflux values and lag times,ranged from 0.2 to 1.5μgcm−2h−1and from 10 to 130 min, respectively, for studies performed at a BTEXconcentration of 51μgL−1in air. Different air concentration of BTEX were evaluated in the calibration chamber,indicating thatflux increased proportionally to the BTEX concentration in air and the lag time decreased as theair concentration of BTEX increased.

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Bu Makaleye Atıf Yap

PONTES-LOPEZ, S., MORENO, J., ESTEVE-TURRİLLAS, F. A., ARMENTA, S. (2020). Development of a simulation chamber for the evaluation of dermalabsorption of volatile organic compounds. Atmospheric Pollution Research, Cilt: 11 - Sayı: 5, 1009–1017. https://ajindex.com/articles/142856

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Kaynakça (13)

  1. Adami, G., Larese, F., Venier, M., Barbieri, P., Lo Coco, F., Reisenhofer, E., 2016.Penetration of benzene, toluene and xylenes contained in gasolines through humanabdominal skin in vitro. Toxicol. Vitro 20, 1321–1330.
  2. Blanck, I.H., McAuliffe, D.J., 1985. Penetration of benzene through human skin. J. Invest.Dermatol. 85, 522–526.
  3. Bouarar, I., Wang, X., Brasseur, G.P., 2017. Air Pollution in Eastern Asia: an IntegratedPerspective,first ed. Springer, Berlin. de la Guardia, M., Armenta, S., 2016. The Quality of Air Comprehensive AnalyticalChemistry, vol. 73 Elsevier, Amsterdam. European Comission, 2007. European regulation on registration, evaluation, authorisa-tion and restriction of chemicals.https://ec.europa.eu/growth/sectors/chemicals/reach_en.
  4. European Environment Agency, Copenhagen, 2019.https://www.eea.europa.eu/themes/air/intro.
  5. Franz, T.J., 1975. Percutaneous absorption: on the relevance of in vitro data. J. Invest.Dermatol. 64, 190–195.
  6. Frasch, H.F., Barbero, A.M., 2018. In vitro human skin permeation of benzene in gasoline:effects of concentration, multiple dosing and skin preparation. J. Expo. Sci. Environ.Epidemiol. 28, 193–201.
  7. Finlayson-Pitts, B.J., Pitts, J.N., 1993. Atmospheric chemistry of tropospheric ozoneformation: scientific and regulatory implications. J. Air Waste Manag. Assoc. 43,1091–1100.
  8. Haq, A., Goodyear, B., Ameen, D., Joshic, V., Michniak-Kohn, B., 2018. Strat-M®syntheticmembrane: permeability comparison to human cadaver skin. Int. J. Pharm. 547,432–437.
  9. Kim, H., Bernstein, J.A., 2009. Air pollution and allergic disease. Curr. Allergy AsthmaRep. 9, 128–133.
  10. Kuranchie, F.A., Angnunavuri, P.N., Attiogbe, F., Nerquaye-Tetteh, E.N., 2019.Occupational exposure of benzene, toluene, ethylbenzene and xylene (BTEX) to pumpattendants in Ghana: implications for policy guidance. Cogent Environ. Sci. 5,1603418. Magnusson, B.M., Anissimov, Y.G., Cross, S.E., Roberts, M.S., 2004. Molecular size as themain determinant of solute maximumflux across the skin. J. Invest. Dermatol. 122,993–999.
  11. Mathes, S.H., Ruffner, H., Graf-Hausner, U., 2014. The use of skin models in drug de-velopment. Adv. Drug Deliv. Rev. 69–70, 81–102.
  12. McDougal, J.N., Pollard, D.L., Weisman, W., Garrett, C.M., Miller, T.E., 2000. Assessmentof skin absorption and penetration of JP-8 jet fuel and its components. Toxicol. Sci.55, 247–255.
  13. McDougal, J.N., Jepson, G.W., Clewell III, H.J., Gargas, M.L., Andersen, M.E., 1990.Dermal absorption of organic chemical vapors in rats and h