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Dergiler / The European Research Journal / 2025 / Volume: 11 Issue: 6

Comparing the effectiveness of different vaccination regimens using Sinovac and BNT162b2 vaccines among hospitalised patients: A single-centre hospital-based retrospective cohort study

Atakan Turan(Department of Bioengineering, Faculty of Engineering and Natural Sciences, Bursa Technical University, Bursa, Türkiye)0000-0002-0745-0296
Hamdi Öğüt(Department of Bioengineering, Faculty of Engineering and Natural Sciences, Bursa Technical University, Bursa, Türkiye)0000-0002-5857-8820
Aylin Ayyıldız Varol(Department of Internal Medicine, Bursa Çekirge State Hospital, Bursa, Türkiye)0000-0003-4967-4447
Nizameddin Koca(Department of Internal Medicine, University of Health Sciences, Bursa City Training and Research Hospital, Bursa, Türkiye)0000-0003-1457-4366
Hayri Bozkurt(Department of Home Care, Bursa Çekirge State Hospital, Bursa, Türkiye)0009-0005-8535-6245
Sayfa
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Yayın Tarihi
2025-11-04
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusions: A two-dose initial plus one or more-dose booster BNT162b2 regimen effectively reduced mortality risks and ICU admission.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objectives: This study aimed to assess the effectiveness of different vaccination regimens using two distinct SARS-CoV-2 vaccines against mortality risk and the need for intensive care unit (ICU) admission among hospitalised patients.
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Temel Bulgular & Veri:Methods: The single-centre hospital-based retrospective cohort study was performed with adult COVID-19 patients in a tertiary-level hospital between March 2020 and September 2022.
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Sonuç & Katkı:Conclusions: A two-dose initial plus one or more-dose booster BNT162b2 regimen effectively reduced mortality risks and ICU admission.
🔬Tür:Research Article
📍Kapsam:2020 Verileri
⚙️Değişkenler:COVID-19 · vaccine · mortality

Abstract

Objectives: This study aimed to assess the effectiveness of different vaccination regimens using two distinct SARS-CoV-2 vaccines against mortality risk and the need for intensive care unit (ICU) admission among hospitalised patients. Methods: The single-centre hospital-based retrospective cohort study was performed with adult COVID-19 patients in a tertiary-level hospital between March 2020 and September 2022. The associations between patients’ demographics and clinical features, vaccine status and regimens, in-hospital mortality, and need for ICU admission were evaluated using multivariable regression analyses. Results: During the study period, 2,373 patients were included. Mortality among unvaccinated patients was 85.0%, which was significantly lower in vaccinated groups (P<0.001), particularly with BNT162b2 than with Sinovac. Vaccination reduced mortality and ICU admission rates, with higher efficacy observed with increased vaccine doses and BNT162b2 regimens. Multivariable analyses confirmed age as a significant determinant and various vaccination schedules showed consistent reductions in mortality and ICU admissions. Conclusions: A two-dose initial plus one or more-dose booster BNT162b2 regimen effectively reduced mortality risks and ICU admission.

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Bu Makaleye Atıf Yap

Turan, A., Öğüt, H., Varol, A. A., Koca, N., Bozkurt, H. (2025). Comparing the effectiveness of different vaccination regimens using Sinovac and BNT162b2 vaccines among hospitalised patients: A single-centre hospital-based retrospective cohort study. The European Research Journal, Volume: 11 Issue: 6. https://doi.org/10.18621/eurj.1632009

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