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Dergiler / Uludağ Üniversitesi Mühendislik Fakültesi Dergisi / 2026 / Cilt: 30 Sayı: 2

BT Görüntülerinde Non-Travmatik Vertebral Kompresyon Kırıklarının DenseNet ve GAN’ları Birleştiren Hibrit Derin Öğrenme Modeli ile Tanımlanması

IDENTIFICATION OF NON-TRAUMATIC VERTEBRAL COMPRESSION FRACTURES IN CT IMAGES USING A HYBRID DEEP LEARNING MODEL COMBINING DENSENET AND GAN

Murat Türkmen(BAŞKENT ÜNİVERSİTESİ)0000-0003-2375-5337
Zeynep Orman(İSTANBUL ÜNİVERSİTESİ - CERRAHPAŞA)0000-0002-0205-4198
Sayfa
339–354
Yayın Tarihi
2025-08-20
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

DenseNet ve GAN’ların kombinasyonu, tıbbi görüntü sınıflandırması için ileri düzey derin öğrenme tekniklerinin etkinliğini ortaya koymakta ve otomatik tıbbi tanıda gelecekteki uygulamalara kapı açmaktadır.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Vertebral kompresyon kırıkları, özellikle yaşlı nüfus arasında yaygın bir durumdur ve genellikle osteoporoz ile diğer dejeneratif hastalıklarla ilişkilidir.
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Temel Bulgular & Veri:Bu durum, daha etkili ve otomatik tespit yöntemlerine olan talebi artırmıştır.
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Sonuç & Katkı:DenseNet ve GAN’ların kombinasyonu, tıbbi görüntü sınıflandırması için ileri düzey derin öğrenme tekniklerinin etkinliğini ortaya koymakta ve otomatik tıbbi tanıda gelecekteki uygulamalara kapı açmaktadır.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Vertebral Kompresyon Kırıkları · DenseNet · Üretici Karşıt Ağlar (GAN’lar)

Özet

Vertebral kompresyon kırıkları, özellikle yaşlı nüfus arasında yaygın bir durumdur ve genellikle osteoporoz ile diğer dejeneratif hastalıklarla ilişkilidir. Travma belirtisi göstermeyen non travmatik vertebral kompresyon kırıkları (VK’lar) tıbbi görüntülerden tanımlanması zor olabilir. Bu durum, daha etkili ve otomatik tespit yöntemlerine olan talebi artırmıştır. Bu çalışma, bilgisayarlı tomografi (BT) görüntülerinden non-travmatik VK’ları tespit etmek için DenseNet ve Üretici Karşıt Ağlar (GAN’lar) kullanan hibrit bir derin öğrenme yaklaşımını önermektedir. Kesin kırıkları olan 101 görüntü ve kırık olmayan 99 görüntü içeren bir hasta BT tarama veri seti kullanılmıştır. Hibrit modelimiz, geleneksel yöntemlere kıyasla üstün bir doğruluk göstermiştir ve kırık ve kırık olmayan vertebra ayırt etme konusunda umut verici sonuçlar sunmuştur. Bu otomatik yöntem, radyologların erken tanı ve tedavi planlamasında yardımcı olabilir, manuel görüntü analizine gereken süreyi azaltarak tanısal doğruluğu artırır. DenseNet ve GAN’ların kombinasyonu, tıbbi görüntü sınıflandırması için ileri düzey derin öğrenme tekniklerinin etkinliğini ortaya koymakta ve otomatik tıbbi tanıda gelecekteki uygulamalara kapı açmaktadır.

Abstract

Vertebral compression fractures are common conditions, particularly in the aging population, often linked to osteoporosis and other degenerative diseases. Non-traumatic vertebral compression fractures (VCFs) can be difficult to identify from medical images, especially those that do not show signs of trauma. This has led to a demand for more effective and automated detection methods. This study proposes a hybrid deep learning approach that uses DenseNet and Generative Adversarial Networks (GANs) to detect nontraumatic VCFs from computed tomography (CT) images. A dataset consisting of patient CT scans was used, including 101 images with confirmed fractures and 99 images without fractures. Our hybrid model demonstrated superior accuracy to conventional methods, showing promising results in distinguishing between fractured and non-fractured vertebrae. This automated method could aid radiologists in early diagnosis and treatment planning by decreasing the time needed for manual image analysis and improving diagnostic accuracy. The combination of DenseNet and GANs demonstrates the effectiveness of using advanced deep-learning techniques for medical image classification, opening the door for future applications in automated medical diagnosis.

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Bu Makaleye Atıf Yap

Türkmen, M., Orman, Z. (2025). BT Görüntülerinde Non-Travmatik Vertebral Kompresyon Kırıklarının DenseNet ve GAN’ları Birleştiren Hibrit Derin Öğrenme Modeli ile Tanımlanması. Uludağ Üniversitesi Mühendislik Fakültesi Dergisi, Cilt: 30 Sayı: 2, 339–354. https://doi.org/10.17482/uumfd.1557032

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Kaynakça (47)

  1. Alsaidi, M., Jan, M. T., Altaher, A., Zhuang, H., & Zhu, X. (2024). Tackling the class imbalanced dermoscopic image classification using data augmentation and GAN. Multimedia Tools and Applications, 83(16), 49121-49147. doi.org/10.1007/s11042-023-17067-1
  2. Atasever, S., Azginoglu, N., Terzi, D. S., & Terzi, R. (2023). A comprehensive survey of deep learning research on medical image analysis with focus on transfer learning. Clinical imaging, 94, 18-41. doi.org/10.1016/j.clinimag.2022.11.003
  3. Bahrami, A., Karimian, A., & Arabi, H. (2021). Comparison of different deep learning architectures for synthetic CT generation from MR images. Physica Medica, 90, 99-107. doi.org/10.1016/j.ejmp.2021.09.006
  4. Bastidas-Rodriguez, M. X., Polania, L., Gruson, A., & Prieto-Ortiz, F. (2020). Deep Learning for fractographic classification in metallic materials. Engineering Failure Analysis, 113, 104532. oi.org/10.1016/j.engfailanal.2020.104532
  5. Ding, Z., Li, H., Guo, Y., Zhou, D., Liu, Y., & Xie, S. (2023). M4fnet: Multimodal medical image fusion network via multi-receptive-field and multi-scale feature integration. Computers in Biology and Medicine, 159, 106923. doi.org/10.1016/j.compbiomed.2023.106923
  6. Faiella, E., Pacella, G., Altomare, C., Bernetti, C., Sarli, M., Cea, L.,. & Grasso, R. F. (2022). Percutaneous vertebroplasty: A minimally invasive procedure for the management of vertebral compression fractures. Osteology, 2(4), 139-151. doi.org/10.3390/osteology2040017
  7. Ferdousi, R., Yang, C., Hossain, M. A., Laamarti, F., Hossain, M. S., & Saddik, A. E. (2024). Generative Model-Driven Synthetic Training Image Generation: An Approach to Cognition in Railway Defect Detection. Cognitive Computation, 1-16. doi.org/10.1007/s12559-024-10283-3
  8. Fei, R., Yao, Q., Zhu, Y., Xu, Q., Li, A., Wu, H., & Hu, B. (2020). Deep Learning Structure for Cross‐Domain Sentiment Classification Based on Improved Cross Entropy and Weight. Scientific Programming, 2020(1), 3810261. doi.org/10.1155/2020/3810261
  9. Fooladgar, F., & Kasaei, S. (2020). Lightweight residual densely connected convolutional neural network. Multimedia Tools and Applications, 79, 25571-25588. doi.org/10.1007/s11042-020-09223
  10. Frid-Adar, M., Diamant, I., Klang, E., Amitai, M., Goldberger, J., & Greenspan, H. (2018). GAN-based synthetic medical image augmentation for increased CNN performance in liver lesion classification. Neurocomputing, 321, 321-331. doi.org/10.1016/j.neucom.2018.09.013
  11. Ghazouani, H., & Barhoumi, W. (2021). Towards non-data-hungry and fully-automated diagnosis of breast cancer from mammographic images. Computers in Biology and Medicine, 139, 105011. doi.org/10.1016/j.compbiomed.2021.105011
  12. Gutiérrez-González, R., Royuela, A., & Zamarron, A. (2023). Survival following vertebral compression fractures in population over 65 years old. Aging Clinical and Experimental Research, 35(8), 1609-1617. doi.org/10.1007/s40520-023-02445-4
  13. Hemalatha, J., Roseline, S. A., Geetha, S., Kadry, S., & Damaševičius, R. (2021). An efficient densenet-based deep learning model for malware detection. Entropy, 23(3), 344. doi.org/10.3390/e23030344
  14. Huang, W., Feng, J., Wang, H., & Sun, L. (2020). A new architecture of densely connected convolutional networks for pan-sharpening. ISPRS International Journal of Geo-Information, 9(4), 242. doi.org/10.3390/ijgi9040242
  15. İncir, R., & Bozkurt, F. (2024). A study on effective data preprocessing and augmentation method in diabetic retinopathy classification using pre-trained deep learning approaches. Multimedia Tools and Applications, 83(4), 12185-12208. doi.org/10.1007/s11042-023-15754-7
  16. Jiang, X., Hu, Z., Wang, S., & Zhang, Y. (2023). Deep learning for medical image-based cancer diagnosis. Cancers, 15(14), 3608. doi.org/10.3390/cancers15143608
  17. Jin, C. B., Kim, H., Liu, M., Han, I. H., Lee, J. I., Lee, J. H.,. & Cui, X. (2019). DC2Anet: generating lumbar spine MR images from CT scan data based on semi-supervised learning. Applied Sciences, 9(12), 2521. doi.org/10.3390/app9122521
  18. Kazeminia, S., Baur, C., Kuijper, A., van Ginneken, B., Navab, N., Albarqouni, S., & Mukhopadhyay, A. (2020). GANs for medical image analysis. Artificial intelligence in medicine, 109, 101938. doi.org/10.1016/j.artmed.2020.101938
  19. Kolanu, N., Silverstone, E. J., Ho, B. H., Pham, H., Hansen, A., Pauley, E.,. & Pocock, N. A. (2020). Clinical utility of computer‐aided diagnosis of vertebral fractures from computed tomography images. Journal of Bone and Mineral Research, 35(12), 2307-2312. doi.org/10.1002/jbmr.4146
  20. Kumar, M. L., Sampath, P., Srinivas, P. V. V. S., Dommeti, D., & Nallapati, S. R. (2023, September). Leveraging Deep Learning for Accurate Detection and Precise Localization of Vertebral Fractures in Medical Imaging. In 2023 4th International Conference on Smart Electronics and Communication (ICOSEC) (pp. 826-833). IEEE. doi: 10.1109/ICOSEC58147.2023.10275972.
  21. Karras, T., Aittala, M., Hellsten, J., Laine, S., Lehtinen, J., & Aila, T. (2020). Training generative adversarial networks with limited data. Advances in neural information processing systems, 33, 12104-12114.
  22. Lindsey, R., Daluiski, A., Chopra, S., Lachapelle, A., Mozer, M., Sicular, S.,. & Potter, H. (2018). Deep neural network improves fracture detection by clinicians. Proceedings of the National Academy of Sciences, 115(45), 11591-11596. doi:10.1073/pnas.1806905115
  23. Meena, T., & Roy, S. (2022). Bone fracture detection using deep supervised learning from radiological images: A paradigm shift. Diagnostics, 12(10), 2420. doi.org/10.3390/diagnostics12102420
  24. Nguyen, T., Le, T., Vu, H., & Phung, D. (2017). Dual discriminator generative adversarial nets. Advances in neural information processing systems, 30. doi.org/10.48550/arXiv.1709.03831
  25. Rather, I. H., & Kumar, S. (2024). Generative adversarial network based synthetic data training model for lightweight convolutional neural networks. Multimedia Tools and Applications, 83(2), 6249-6271. doi.org/10.1007/s11042-023-15747-6
  26. Saxena, D., & Cao, J. (2021). Generative adversarial networks (GANs) challenges, solutions, and future directions. ACM Computing Surveys (CSUR), 54(3), 1-42. doi.org/10.1145/3446374
  27. Shazia, A., Xuan, T. Z., Chuah, J. H., Usman, J., Qian, P., & Lai, K. W. (2021). A comparative study of multiple neural network for detection of COVID-19 on chest X-ray. EURASIP journal on advances in signal processing, 2021, 1-16. doi.org/10.1186/s13634-021-00755-1
  28. Shin, H. C., Tenenholtz, N. A., Rogers, J. K., Schwarz, C. G., Senjem, M. L., Gunter, J. L.,. & Michalski, M. (2018). Medical image synthesis for data augmentation and anonymization using generative adversarial networks. In Simulation and Synthesis in Medical Imaging: Third International Workshop, SASHIMI 2018, Springer International Publishing. doi.org/10.48550/arXiv.1807.10225
  29. Story, M., & Congalton, R. G. (1986). Accuracy assessment: a user’s perspective. Photogrammetric Engineering and remote sensing, 52(3), 397-399.
  30. Teoh, L., Ihalage, A. A., Harp, S., F. Al-Khateeb, Z., Michael-Titus, A. T., Tremoleda, J. L., & Hao, Y. (2022). Deep learning for behaviour classification in a preclinical brain injury model. PLoS one, 17(6), e0268962. doi.org/ 10.1371/journal.pone.0268962
  31. Tian, Y., Wang, Q., Huang, Z., Li, W., Dai, D., Yang, M.,. & Fink, O. (2020). Off-policy reinforcement learning for efficient and effective gan architecture search. In Computer Vision–ECCV 2020: 16th European Conference, Glasgow, UK, August 23–28, 2020, Proceedings, Part VII 16 (pp. 175-192). Springer International Publishing. doi.org/10.48550/arXiv.2007.09180
  32. Verma, R., Mehrotra, R., Rane, C., Tiwari, R., & Agariya, A. K. (2020). Synthetic image augmentation with generative adversarial network for enhanced performance in protein classification. Biomedical Engineering Letters, 10, 443-452. doi.org/10.1007/s13534-020-00162-9
  33. Wang, J., Zhu, H., Wang, S. H., & Zhang, Y. D. (2021). A review of deep learning on medical image analysis. Mobile Networks and Applications, 26(1), 351-380. doi.org/10.1007/s11036-020-01672-7
  34. Wardhani, N. W. S., Rochayani, M. Y., Iriany, A., Sulistyono, A. D., & Lestantyo, P. (2019, October). Cross-validation metrics for evaluating classification performance on imbalanced data. In 2019 international conference on computer, control, informatics and its applications (IC3INA) (pp. 14-18). IEEE. doi.org/10.1109/IC3INA48034.2019.8949568
  35. Xue, Y., Ye, J., Zhou, Q., Long, L. R., Antani, S., Xue, Z.,. & Huang, X. (2021). Selective synthetic augmentation with HistoGAN for improved histopathology image classification. Medical image analysis, 67, 101816. doi.prg/10.1016/j.media.2020.101816
  36. Yu, C., He, X., Ma, H., Qi, X., Lu, J., & Zhao, Y. (2019). S-DenseNet: a DenseNet compression model based on convolution grouping strategy using skyline method. IEEE Access, 7, 183604-183613. doi.org/10.1109/ACCESS.2019.2960315
  37. Yu, H., Yang, L. T., Zhang, Q., Armstrong, D., & Deen, M. J. (2021). Convolutional neural networks for medical image analysis: state-of-the-art, comparisons, improvement and perspectives. Neurocomputing, 444, 92-110. doi.org/10.1016/j.neucom.2020.04.157
  38. Zhang, J., Zheng, B., Gao, A., Feng, X., Liang, D., & Long, X. (2021). A 3D densely connected convolution neural network with connection-wise attention mechanism for Alzheimer's disease classification. Magnetic Resonance Imaging, 78, 119-126. doi.org/10.1016/j.mri.2021.02.001
  39. Zhou, S. K., Greenspan, H., Davatzikos, C., Duncan, J. S., Van Ginneken, B., Madabhushi, A.,. & Summers, R. M. (2021). A review of deep learning in medical imaging: Imaging traits, technology trends, case studies with progress highlights, and future promises. Proceedings of the IEEE, 109(5), 820-838. doi.org/10.1109/JPROC.2021.3054390
  40. Faiella, E., Pacella, G., Altomare, C., Bernetti, C., Sarli, M., Cea, L.,. & Grasso, R. F. (2022). Percutaneous vertebroplasty: A minimally invasive procedure for the management of vertebral compression fractures. Osteology, 2(4), 139-151. doi.org/10.3390/osteology2040017
  41. Jin, C. B., Kim, H., Liu, M., Han, I. H., Lee, J. I., Lee, J. H.,. & Cui, X. (2019). DC2Anet: generating lumbar spine MR images from CT scan data based on semi-supervised learning. Applied Sciences, 9(12), 2521. doi.org/10.3390/app9122521
  42. Kolanu, N., Silverstone, E. J., Ho, B. H., Pham, H., Hansen, A., Pauley, E.,. & Pocock, N. A. (2020). Clinical utility of computer‐aided diagnosis of vertebral fractures from computed tomography images. Journal of Bone and Mineral Research, 35(12), 2307-2312. doi.org/10.1002/jbmr.4146
  43. Lindsey, R., Daluiski, A., Chopra, S., Lachapelle, A., Mozer, M., Sicular, S.,. & Potter, H. (2018). Deep neural network improves fracture detection by clinicians. Proceedings of the National Academy of Sciences, 115(45), 11591-11596. doi:10.1073/pnas.1806905115
  44. Shin, H. C., Tenenholtz, N. A., Rogers, J. K., Schwarz, C. G., Senjem, M. L., Gunter, J. L.,. & Michalski, M. (2018). Medical image synthesis for data augmentation and anonymization using generative adversarial networks. In Simulation and Synthesis in Medical Imaging: Third International Workshop, SASHIMI 2018, Springer International Publishing. doi.org/10.48550/arXiv.1807.10225
  45. Tian, Y., Wang, Q., Huang, Z., Li, W., Dai, D., Yang, M.,. & Fink, O. (2020). Off-policy reinforcement learning for efficient and effective gan architecture search. In Computer Vision–ECCV 2020: 16th European Conference, Glasgow, UK, August 23–28, 2020, Proceedings, Part VII 16 (pp. 175-192). Springer International Publishing. doi.org/10.48550/arXiv.2007.09180
  46. Xue, Y., Ye, J., Zhou, Q., Long, L. R., Antani, S., Xue, Z.,. & Huang, X. (2021). Selective synthetic augmentation with HistoGAN for improved histopathology image classification. Medical image analysis, 67, 101816. doi.prg/10.1016/j.media.2020.101816
  47. Zhou, S. K., Greenspan, H., Davatzikos, C., Duncan, J. S., Van Ginneken, B., Madabhushi, A.,. & Summers, R. M. (2021). A review of deep learning in medical imaging: Imaging traits, technology trends, case studies with progress highlights, and future promises. Proceedings of the IEEE, 109(5), 820-838. doi.org/10.1109/JPROC.2021.3054390