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Dergiler / Communications Faculty of Sciences University of Ankara Series A2-A3 Physical Sciences and Engineering / 2025 / Volume: 67 Issue: 2

Assessing the impact of lifestyle and viral factors on oral cancer: exploratory data analysis

Murat Türkmen(BASKENT UNIVERSITY)0000-0003-2375-5337
Ahmet Turgut Tuncer(BASKENT UNIVERSITY)0000-0003-1067-1820
Sayfa
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Yayın Tarihi
2025-12-24
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The findings of this study furnish invaluable insights for policymakers, healthcare practitioners, and researchers, thereby fostering the formulation of more efficacious and evidence-based interventions in the global effort to combat oral cancer.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Oral cancer represents a growing global health concern, with rising incidence and mortality rates particularly in low- and middle-income countries.
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Temel Bulgular & Veri:The disease not only poses significant clinical challenges but also exerts substantial socioeconomic burdens due to treatment costs and productivity losses.
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Sonuç & Katkı:The findings of this study furnish invaluable insights for policymakers, healthcare practitioners, and researchers, thereby fostering the formulation of more efficacious and evidence-based interventions in the global effort to combat oral cancer.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Oral cancer · exploratory data analysis · epidemiology

Abstract

Oral cancer represents a growing global health concern, with rising incidence and mortality rates particularly in low- and middle-income countries. The disease not only poses significant clinical challenges but also exerts substantial socioeconomic burdens due to treatment costs and productivity losses. This study undertakes a meticulous exploratory data analysis (EDA) to scrutinize epidemiology and socioeconomic repercussions of oral cancers. In this study, the Oral Cancer Prediction Dataset from Kaggle is employed to investigate the relationship between patient demographics, lifestyle habits, and oral cancer diagnosis, providing valuable insights into potential risk factors. The analysis reveals robust correlations between pivotal risk factors, including tobacco consumption, alcohol intake, human papillomavirus (HPV) infection, and betel quid usage, and the diagnosis of oral cancer. Notably, demographic trends manifest a pronounced concentration among males aged 45-65, coupled with a dramatic decline in survival rates during advanced stages, underscoring the severity of the disease. The prevalence of elevated case rates in nations such as India and Pakistan, juxtaposed with the escalating incidence of HPV-related cases in Western countries, elucidates the geographical disparities and the critical influence of regional risk determinants. Furthermore, the substantial economic burden is exemplified by annual productivity losses ranging from 30-180 workdays and treatment expenditures spanning $20,000-$80,000. The importance of early detection is underscored by survival rates approximating 80% in early-stage diagnoses, thereby accentuating the imperative for data-driven methodologies and proactive early detection initiatives in the global campaign against oral cancer. This research elucidates that oral cancer transcends individual health concerns, constituting a complex public health challenge with profound ramifications for societal well-being and economic stability. Consequently, the risk factor mitigation, augmentation of public awareness, and the development of accessible screening programs emerge as critical strategies in the comprehensive management of oral cancer. The findings of this study furnish invaluable insights for policymakers, healthcare practitioners, and researchers, thereby fostering the formulation of more efficacious and evidence-based interventions in the global effort to combat oral cancer.

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Bu Makaleye Atıf Yap

Türkmen, M., Tuncer, A. T. (2025). Assessing the impact of lifestyle and viral factors on oral cancer: exploratory data analysis. Communications Faculty of Sciences University of Ankara Series A2-A3 Physical Sciences and Engineering, Volume: 67 Issue: 2. https://doi.org/10.33769/aupse.1680870

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Kaynakça (25)

  1. Rai, H. M., Yoo, J., Razaque, A., Comparative analysis of machine learning and deep learning models for improved cancer detection: A comprehensive review of recent advancements in diagnostic techniques, Expert Syst. Appl., 124838 (2024). https://doi.org/10.1016/j.eswa.2024.124838.
  2. Elmore, L. W., Greer, S. F., Daniels, E. C., Saxe, C. C., Melner, M. H., Krawiec, G. M., et al., Blueprint for cancer research: critical gaps and opportunities, CA Cancer J. Clin., 71 (2) (2021), 107–139. https://doi.org/10.3322/caac.21652.
  3. Petti, S., Lifestyle risk factors for oral cancer, Oral Oncol., 45 (4–5) (2009), 340–350. https://doi.org/10.1016/j.oraloncology.2008.05.018.
  4. Levin, R., Villanueva, C. M., Beene, D., Cradock, A. L., Donat-Vargas, C., Lewis, J., et al., US drinking water quality: exposure risk profiles for seven legacy and emerging contaminants, J. Expo. Sci. Environ. Epidemiol., 34 (1) (2024), 3–22. https://doi.org/10.1038/s41370-023-00597-z.
  5. Herdiana, Y., Alcohol in Daily Products: Health Risks, Cultural Considerations, and Economic Impacts, Risk Manag. Healthc. Policy, (2025), 217–237. https://doi.org/10.2147/RMHP.S495493.
  6. Hamidullah, S., Thorpe, H. H., Frie, J. A., Mccurdy, R. D., Khokhar, J. Y., Adolescent substance use and the brain: behavioral, cognitive and neuroimaging correlates, Front. Hum. Neurosci., 14 (2020), 298. https://doi.org/10.3389/fnhum.2020.00298.
  7. Ullah, M. I., Mikhailova, M. V., Alkhathami, A. G., Carbajal, N. C., Zuta, M. E. C., Rasulova, I., et al., Molecular pathways in the development of HPV-induced oropharyngeal cancer, Cell Commun. Signal., 21 (1) (2023), 351. https://doi.org/10.1186/s12964-023-01365-0.
  8. Wünsch-Filho, V., The epidemiology of oral and pharynx cancer in Brazil, Oral Oncol., 38 (8) (2002), 737–746. https://doi.org/10.1016/S1368-8375(02)00066-0.
  9. Lechner, M., Liu, J., Masterson, L., Fenton, T. R., HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management, Nat. Rev. Clin. Oncol., 19 (5) (2022), 306–327. https://doi.org/10.1038/s41571-022-00603-7.
  10. Tran, N. H., Sais, D., Tran, N., Advances in human papillomavirus detection and molecular understanding in head and neck cancers: Implications for clinical management, J. Med. Virol., 96 (6) (2024), e29746. https://doi.org/10.1002/jmv.29746.
  11. McKeon, M. G., Gallant, J. N., Kim, Y. J., Das, S. R., It takes two to tango: A review of oncogenic virus and host microbiome associated inflammation in head and neck cancer, Cancers, 14 (13) (2022), 3120. https://doi.org/10.3390/cancers14133120.
  12. Zavras, A., Andreopoulos, N., Katsikeris, N., Zavras, D., Cartsos, V., Vamvakidis, A., Oral cancer treatment costs in Greece and the effect of advanced disease, BMC Public Health, 2 (2002), 1–8. https://doi.org/10.1186/1471-2458-2-12.
  13. Zhang, Q., Hou, D., Wen, X., Xin, M., Li, Z., Wu, L., Pathak, J. L., Gold nanomaterials for oral cancer diagnosis and therapy: advances, challenges, and prospects, Mater. Today Bio, 15 (2022), 100333. https://doi.org/10.1016/j.mtbio.2022.100333.
  14. Boffetta, P., & Hashibe, M. (2006). Alcohol and cancer. The lancet oncology, 7(2), 149-156. https://doi.org/10.1016/S1470-2045(06)70577-0.
  15. Warnakulasuriya, S., Global epidemiology of oral and oropharyngeal cancer, Oral Oncol., 45 (4–5) (2009), 309–316. https://doi.org/10.1016/j.oraloncology.2008.06.002.
  16. Bagnardi, V., Rota, M., Botteri, E., Tramacere, I., Islami, F., Fedirko, V., et al., Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis, Br. J. Cancer, 112 (3) (2015), 580–593. https://doi.org/10.1038/bjc.2014.579.
  17. Chaturvedi, A. K., Engels, E. A., Pfeiffer, R. M., Agalliu, I., Li, R. J., King, C. M., et al., Human papillomavirus and rising oropharyngeal cancer incidence in the United States, J. Clin. Oncol., 29 (32) (2011), 4294–4301. https://doi.org/10.1200/JCO.2011.36.4596.
  18. Gillison, M. L., Chaturvedi, A. K., Anderson, W. F., Fakhry, C., Epidemiology of HPV-positive head and neck squamous cell carcinoma, J. Clin. Oncol., 33 (29) (2015), 3235–3242. https://doi.org/10.1200/JCO.2015.61.6995.
  19. Gupta, P. C., Johnson, N. W., Global epidemiology of areca nut use, Addict. Biol., 19 (1) (2014), 129–138. https://doi.org/10.1080/13556210020091437.
  20. Warnakulasuriya, S., Oral submucous fibrosis: a model for oral carcinogenesis, Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod., 94 (5) (2002), 557–564. https://doi.org/10.1016/j.oooo.2016.02.020.
  21. Brennan, P. J., Brigl, M., & Brenner, M. B. (2013). Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nature Reviews Immunology, 13(2), 101-117. https://doi.org/10.1038/nri3369.
  22. Rogers, S. N., Brown, J. S., Woolgar, J. A., Survival following primary surgery for oral cancer in a UK centre: a review of 1000 consecutive cases, Oral Oncol., 48 (2) (2012), 165–171. https://doi.org/10.1016/j.oraloncology.2008.05.008.
  23. Johnson, N. W., Jayasekara, P., Amarasinghe, A. H. K., & Hemantha, K. (2011). Squamous cell carcinoma and precursor lesions of the oral cavity: epidemiology and aetiology. Periodontology 2000, 57(1), 19. https://doi.org/10.1111/j.1600-0757.2011.00401.x.
  24. Mehrotra, R., & Yadav, K. (2022). Breast cancer in India: Present scenario and the challenges ahead. World Journal of Clinical Oncology, 13(3), 209. https://doi.org/10.5306/wjco.v13.i3.209.
  25. Ankit, Oral Cancer Prediction Dataset [Data set], Kaggle, (2025). https://doi.org/10.34740/KAGGLE/DSV/10942559.