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Dergiler / Osmangazi Tıp Dergisi / 2026 / Cilt: 48 Sayı: 1

Concomitant Endometrioid Endometrial Carcinoma and Adult-Type Granulosa Cell Tumor in an Elderly Patient with Mismatch Repair Deficiency: A Case Report

Müge Ateş Tıkız(AKDENİZ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-0813-2094
Elif Iltar(AKDENİZ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8612-7533
Fatma Ceren Güner(AKDENİZ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-8654-7426
Selen Dogan(AKDENİZ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-4019-5581
Sayfa
137–140
Yayın Tarihi
2025-12-15
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The case is discussed in light of current literature with consideration of its relevance to Lynch syndrome and the implications for genetic counseling.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:We present the case of an 82-year-old woman who was admitted with postmenopausal bleeding and was subsequently diagnosed with synchronous endometrioid endometrial carcinoma (FIGO grade 2) and adult-type granulosa cell tumor of the ovary.
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Temel Bulgular & Veri:Histopathological and immunohistochemical analyses revealed mismatch repair (MMR) deficiency with loss of MLH1 and PMS2 expression.
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Sonuç & Katkı:The case is discussed in light of current literature with consideration of its relevance to Lynch syndrome and the implications for genetic counseling.
🔬Tür:Olgu Sunumu
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Endometriyal karsinom · Granüloza hücreli tümör · MMR yetmezliği

Özet

We present the case of an 82-year-old woman who was admitted with postmenopausal bleeding and was subsequently diagnosed with synchronous endometrioid endometrial carcinoma (FIGO grade 2) and adult-type granulosa cell tumor of the ovary. Histopathological and immunohistochemical analyses revealed mismatch repair (MMR) deficiency with loss of MLH1 and PMS2 expression. The coexistence of these two tumor types in a single patient, particularly in the context of MMR deficiency, is extremely rare. The case is discussed in light of current literature with consideration of its relevance to Lynch syndrome and the implications for genetic counseling.

Abstract

We present the case of an 82-year-old woman who was admitted with postmenopausal bleeding and was subsequently diagnosed with synchronous endometrioid endometrial carcinoma (FIGO grade 2) and adult-type granulosa cell tumor of the ovary. Histopathological and immunohistochemical analyses revealed mismatch repair (MMR) deficiency with loss of MLH1 and PMS2 expression. The coexistence of these two tumor types in a single patient, particularly in the context of MMR deficiency, is extremely rare. The case is discussed in light of current literature with consideration of its relevance to Lynch syndrome and the implications for genetic counseling.

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Bu Makaleye Atıf Yap

Tıkız, M. A., Iltar, E., Güner, F. C., Dogan, S. (2025). Concomitant Endometrioid Endometrial Carcinoma and Adult-Type Granulosa Cell Tumor in an Elderly Patient with Mismatch Repair Deficiency: A Case Report. Osmangazi Tıp Dergisi, Cilt: 48 Sayı: 1, 137–140. https://doi.org/10.20515/otd.1698081

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Kaynakça (9)

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  3. Schumer ST, Cannistra SA. Granulosa cell tumor of the ovary. J Clin Oncol. 2003;21(6):1180-9.
  4. Jamieson S, Fuller PJ. Molecular pathogenesis of granulosa cell tumors of the ovary. Endocr Rev. 2012;33(1):109-44.
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  6. Ryan NAJ, Evans DG, Green K, Crosbie EJ. Pathological features and clinical behavior of Lynch syndrome-associated ovarian cancer. Gynecol Oncol. 2017;144(3):491-5
  7. Stelloo E, Jansen AML, Osse EM, Nout RA, Creutzberg CL, Ruano D, et al. Practical guidance for mismatch repair-deficiency testing in endometrial cancer. Ann Oncol. 2017;28(1):96-102.
  8. Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, et al. Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science. 2017;357(6349):409-13.
  9. Gupta P, Kapatia G, Gupta N, Ballari N, Rai B, Suri V, et al. Mismatch Repair Deficiency in Adult Granulosa Cell Tumors: an Immunohistochemistry-based Preliminary Study. Appl Immunohistochem Mol Morphol. 2022;30(8):540-8.