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Journals / Osmangazi Tıp Dergisi / 2025 / Cilt: 48 Sayı: 1

Concomitant Endometrioid Endometrial Carcinoma and Adult-Type Granulosa Cell Tumor in an Elderly Patient with Mismatch Repair Deficiency: A Case Report

Mismatch Repair Yetmezliği Olan Yaşlı Bir Hastada Eş Zamanlı Endometrioid Endometriyal Karsinom ve Erişkin Tip Granüloza Hücreli Tümör: Bir Olgu Sunumu

Müge Ateş Tıkız(AKDENİZ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0003-0813-2094
Elif Iltar(AKDENİZ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-8612-7533
Fatma Ceren Güner(AKDENİZ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0001-8654-7426
Selen Dogan(AKDENİZ ÜNİVERSİTESİ, TIP FAKÜLTESİ)0000-0002-4019-5581
Pages
137–140
Publication Date
2025-12-15
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The case is discussed in light of current literature with consideration of its relevance to Lynch syndrome and the implications for genetic counseling.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:We present the case of an 82-year-old woman who was admitted with postmenopausal bleeding and was subsequently diagnosed with synchronous endometrioid endometrial carcinoma (FIGO grade 2) and adult-type granulosa cell tumor of the ovary.
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Key Findings & Data:Histopathological and immunohistochemical analyses revealed mismatch repair (MMR) deficiency with loss of MLH1 and PMS2 expression.
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Conclusion & Impact:The case is discussed in light of current literature with consideration of its relevance to Lynch syndrome and the implications for genetic counseling.
🔬Design:Olgu Sunumu
📍Scope:Comprehensive Sample
⚙️Variables:Endometriyal karsinom · Granüloza hücreli tümör · MMR yetmezliği

Abstract

We present the case of an 82-year-old woman who was admitted with postmenopausal bleeding and was subsequently diagnosed with synchronous endometrioid endometrial carcinoma (FIGO grade 2) and adult-type granulosa cell tumor of the ovary. Histopathological and immunohistochemical analyses revealed mismatch repair (MMR) deficiency with loss of MLH1 and PMS2 expression. The coexistence of these two tumor types in a single patient, particularly in the context of MMR deficiency, is extremely rare. The case is discussed in light of current literature with consideration of its relevance to Lynch syndrome and the implications for genetic counseling.

Özet

We present the case of an 82-year-old woman who was admitted with postmenopausal bleeding and was subsequently diagnosed with synchronous endometrioid endometrial carcinoma (FIGO grade 2) and adult-type granulosa cell tumor of the ovary. Histopathological and immunohistochemical analyses revealed mismatch repair (MMR) deficiency with loss of MLH1 and PMS2 expression. The coexistence of these two tumor types in a single patient, particularly in the context of MMR deficiency, is extremely rare. The case is discussed in light of current literature with consideration of its relevance to Lynch syndrome and the implications for genetic counseling.

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Cite This Article

Tıkız, M. A., Iltar, E., Güner, F. C., Dogan, S., *, M. A. T. (2025). Concomitant Endometrioid Endometrial Carcinoma and Adult-Type Granulosa Cell Tumor in an Elderly Patient with Mismatch Repair Deficiency: A Case Report. Osmangazi Tıp Dergisi, Cilt: 48 Sayı: 1, 137–140. https://doi.org/10.20515/otd.1698081

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References (9)

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