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Dergiler / Hacettepe Journal of Biology and Chemistry / 2016 / Volume: 44 Issue: 4

Yeni Modifiye Poli maleik anhidrid-ko-vinil asetat /Akriflavin Konjugatının Sentezi, Yapısal Karakterizasyonu ve Suda Çözünürlüğü

Synthesis, Structural Characterization, and Water Solubility of a Novel Modified Poly maleic anhydride-co-vinyl acetate /Acriflavine Conjugate

Gülderen Karakuş(Cumhuriyet University, Department of Pharmaceutical Chemistry, Sivas, Turkey.)
Sayfa
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Yayın Tarihi
2016-11-01
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Spektroskopik analiz sonuçları konjugasyon/modifikasyon tepkimesinin başarılı bir şekilde amidleşme reaksiyonu ile olduğunu doğrulamaktadır

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Y eni fonksiyonel poli maleik anhidrit-ko-vinil asetat /Akriflavin konjugatı, MAVA/AF, iki farklı yolla kopolimer:ilaç oranı sırasıyla 1:1 ve 1:2 olacak şekilde sentezlendi.
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Temel Bulgular & Veri:Saflaştırılan kopolimer, MAVA, antikanser aktif akriflavin AF ajanı ile 60°C’da 72 saat dimetilformamid DMF içinde, trietilamin TEA katalizörlüğünde modifiye edildi.
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Sonuç & Katkı:Spektroskopik analiz sonuçları konjugasyon/modifikasyon tepkimesinin başarılı bir şekilde amidleşme reaksiyonu ile olduğunu doğrulamaktadır
🔬Tür:Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Poly maleic anhydride-co-vinyl acetate modification · acriflavine · FTIR

Özet

Y eni fonksiyonel poli maleik anhidrit-ko-vinil asetat /Akriflavin konjugatı, MAVA/AF, iki farklı yolla kopolimer:ilaç oranı sırasıyla 1:1 ve 1:2 olacak şekilde sentezlendi. Konjugasyon tepkimesi için toksik olmayan polimerik ilaç taşıyıcı hazırlandı. Saflaştırılan kopolimer, MAVA, antikanser aktif akriflavin AF ajanı ile 60°C’da 72 saat dimetilformamid DMF içinde, trietilamin TEA katalizörlüğünde modifiye edildi. Yapısal karakterizasyon Fourier Transform Infrared FTIR ve Nükleer Magnetik Rezonans 1H-NMR ile yapıldı. Spektroskopik analiz sonuçları konjugasyon/modifikasyon tepkimesinin başarılı bir şekilde amidleşme reaksiyonu ile olduğunu doğrulamaktadır

Abstract

Novel functional poly maleic anhydride-co-vinyl acetate /acriflavine conjugate, MAVA/AF, was synthesized in two different ways that copolymer:drug ratio was designed as 1:1 and 1:2, respectively. Nontoxic poly- meric drug carrier was prepared for conjugation reaction. The purified copolymer, MAVA, was modified with an antiexternal fungal and anticancer active agent acriflavine AF at 60°C for 72 hours in dimethylformami- de DMF , using triethylamine TEA as the catalyst. Structural characterizations were carried out by Fourier Transform Infrared FTIR and Nuclear Magnetic Resonance 1H-NMR . The spectroscopic results confirmed that conjugated/modification reaction was successfully carried out by amidification reaction.

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Bu Makaleye Atıf Yap

Karakuş, G. (2016). Yeni Modifiye Poli maleik anhidrid-ko-vinil asetat /Akriflavin Konjugatının Sentezi, Yapısal Karakterizasyonu ve Suda Çözünürlüğü. Hacettepe Journal of Biology and Chemistry, Volume: 44 Issue: 4. https://ajindex.com/articles/1270783

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