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Dergiler / Hacettepe Journal of Biology and Chemistry / 2026 / Volume: 45 Issue: 2

4H-1,2,4-triazol-5- 4-Bromofenoksimetil -3- 4-Substitue Benzil Sülfidin Sentezi, Karakterizasyonu ve Antibakteriyel Aktivitesinin Değerlendirilmesi

Synthesis, Characterization, and Evaluation Of Antibacterial 4H-1,2,4-triazole-5- 4-Bromophenoxymethyl -3- 4-substituted Benzyl sulfide

Mazin N. Mousa(Department of Pharmaceutical Chemistry, College of Pharmacy, Basrah University, Basrah, Iraq.)
Sayfa
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Yayın Tarihi
2017-06-01
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Fakat bunların hiçbiri standart Sefuroksime göre daha yüksek etkiye sahip değildir

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Amaç & Hipotez:H-1, 2,4-triazol-5- 4-Bromofenoksimetil -3- 4-substitue benzil sülfid türevli serisi 6a-6g tasarlanmış ve hazırlanmıştır.
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Temel Bulgular & Veri:Yapılar, FT-IR spektroskopisi, elemental analiz ve 1H NMR kullanılarak doğrulanmıştır.
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Sonuç & Katkı:Fakat bunların hiçbiri standart Sefuroksime göre daha yüksek etkiye sahip değildir
🔬Tür:Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:4-triazole · antibacterial · sulfide

Özet

H-1, 2,4-triazol-5- 4-Bromofenoksimetil -3- 4-substitue benzil sülfid türevli serisi 6a-6g tasarlanmış ve hazırlanmıştır. Yapılar, FT-IR spektroskopisi, elemental analiz ve 1H NMR kullanılarak doğrulanmıştır. Antibakteriyel çalışmalar, gram+ve Staphylococcus aureus ve Bacillus cereus ve gram mikro mikroorganizmalar Escherichia coli ve Pseudomonas aeruginosa kullanılmış ve disk difüzyon yöntemi ile antibakteriyel aktivitenin değerlendirilmesiyle gerçekleştirilmiştir. Bileşik 6a en düşük etkiyi gösterirken, bileşik 6d en yüksek etkiyi göstermiştir. Hazırlanan bileşiklerin hepsi antibakteriyel etkiye sahiptir. Fakat bunların hiçbiri standart Sefuroksime göre daha yüksek etkiye sahip değildir

Abstract

Aseries of 4H-1,2,4-triazole-5- 4-Bromophenoxymethyl - 3- 4-substitutedBenzyl sulfide derivative 6a-6g were designed and prepared. The structures have been confirmed using FT-IR spectroscopy, elemental analysis and 1H NMR.Antibacterial study was done using gram+ve Staphylococcus aureus, and Bacillus cereus and gram+ve microorganisms E. coli, and Pseudomonas aeruginosa and disc diffusion method for evaluation of antibacterial activity. Compound 6d showed the highest effect, while compound 6a showed the lowest. All of the prepared compound has antibacterial activity, but none of them has higher effect than the standard Cefuroxime.

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Bu Makaleye Atıf Yap

Mousa, M. N. (2017). 4H-1,2,4-triazol-5- 4-Bromofenoksimetil -3- 4-Substitue Benzil Sülfidin Sentezi, Karakterizasyonu ve Antibakteriyel Aktivitesinin Değerlendirilmesi. Hacettepe Journal of Biology and Chemistry, Volume: 45 Issue: 2. https://ajindex.com/articles/1270748

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