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Dergiler / Gazi University Journal of Science / 2026 / Volume: 24 Issue: 2

The Effects of Potassium Bromate and Resveratrol on Fatty Acid Levels in Heart, Muscle and Brain of Wistar Rats

Serhat Keser
Okkes Yılmaz
Mehmet Tuzcu
Sayfa
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Yayın Tarihi
2011-04-05
DOI
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Key Words: Resveratrol, KBrO 3 , Heart, Muscle, Brain.   .

📌 3 Maddede Bu Makale

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Amaç & Hipotez:The aim of this study was to examine the effects of antioxidant resveratrol and carcinogen KBrO 3 on the level of fatty acids in heart, muscle and brain of old female Wistar rats.
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Temel Bulgular & Veri:In this study Wistar rats were randomly divided into three groups: 1.
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Sonuç & Katkı:Key Words: Resveratrol, KBrO 3 , Heart, Muscle, Brain.   .
🔬Tür:Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Resveratrol · KBrO3 · Heart

Abstract

The aim of this study was to examine the effects of antioxidant resveratrol and carcinogen KBrO 3 on the level of fatty acids in heart, muscle and brain of old female Wistar rats. In this study Wistar rats were randomly divided into three groups: 1. Control (C), 2. KBrO 3 (P) (80 mg/kg, i.p. single dose) 3. Resveratrol+KBrO 3 (Res) (80 mg/kg KBrO 3 i.p. single dose, 33 mg/kg resveratrol, every other day, for 35 days). In heart, muscle and brain, fatty acid levels were measured by gas chromatography. &nbsp; In the present study, palmitoleic acid (16:1) and oleic acid (18:1) levels were significantly increased in the P and Res groups (p<0.05, p<0.001, respectively). Stearic acid (18:0) and docosahexaenoic acid (22:6) levels were significantly decreased in the P and Res groups (p<0.01, p<0.05, respectively) in the heart. Palmitoleic acid (16:1), oleic acid (18:1) and linolenic acid (18:3) levels were significantly increased in the P and Res groups (p<0.01, p<0.001, p<0.05, respectively). Docosahexaenoic acid (22:6) level was decreased in the P and Res groups (p<0.05) in the muscle. Palmitoleic acid (16:1) and stearic acid (18:0) levels were decreased in the Res group (p<0.05) in the brain. Our results confirm that resveratrol and KBrO 3 treatment were affected the amount of important fatty acids which substrates in fatty acids metabolism of heart, muscle and brain of Wistar rats. Key Words: Resveratrol, KBrO 3 , Heart, Muscle, Brain. &nbsp; .

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Bu Makaleye Atıf Yap

Keser, S., Yılmaz, O., Tuzcu, M. (2011). The Effects of Potassium Bromate and Resveratrol on Fatty Acid Levels in Heart, Muscle and Brain of Wistar Rats. Gazi University Journal of Science, Volume: 24 Issue: 2. https://ajindex.com/articles/1269922

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Kaynakça (41)

  1. Langcake, P., and Pryce, R.J., “The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection and injury.” Physiology and Plant Pathology, 9: 77-86, (1976).
  2. Siemann, E.H., and Creasy, L.L., “Concentration of the phytoalexin resveratrol in wine.”, American Journal of Enology and Viticulture, 43: 49-52, (1992).
  3. Frankel, E.N., Kanner, J., German, J.B., Parks, E., and Kinsella, J.E., “Inhibition of oxidation of human-low density lipoprotein by phenolic substances in red wine.”, Lancet, 341: 454-457, (1993).
  4. Frankel, E.N., Waterhouse, A.L., and Kinsella, J.E., “Inhibition of human LDL oxidation by resveratrol.”, Lancet, 341: 1103-1104, (1993).
  5. Constant, J., “Alcohol, ischemic heart disease, and the French paradox.”, Coronary Artery Disease, 8: 645-649, (1997).
  6. Belguendouz, L., Fremont, L., and Linard, A., “Resveratrol inhibits metal ion-dependent and independent peroxidation of porcine low-density lipoproteins.”, Biochemical Pharmacology, 53: 1347-1355, (1997).
  7. Belguendouz, L., Fremont, L., and Gozzelino, M.T., “Interaction of trans resveratrol with plasma lipoproteins.”, Biochemical Pharmacology, 55: 811-816, (1998).
  8. Wilson, T., Knight, T.J., Beitz, D.C., Lewis, D.S., and Engen, R.L., “Resveratrol promotes atherosclerosis in hypercholesterolemic rabbits.”, Life Sciences, 59: 15-21, (1996).
  9. Turrens, J.E., Lariccia, J., and Nair, M.G., “Resveratrol has no effect on lipoprotein profile and does not prevent peroxidation of serum lipids in normal rats.”, Free Radical Research, 27: 557- 562, (1997).
  10. Chipman, J.K., Davies, J.E., Parsons, J.L., Nair, J., O’Neill, G., and Fawell, J.K., “DNA oxidation by potassium bromate; a direct mechanism or linked to lipid peroxidation.”, Toxicology, 126(2): 93– 102, (1998).
  11. Cadenas, S., and Barja, G., “Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA damage induced by the kidney carcinogen KBrO3.”, Free Radical Biology and Medicine, 26: 1531–1537, (1999).
  12. Sai, K., Takagi, A., Umemura, T., Hasegawa, R., and Kurokawa, Y., “Relation of 8- hydroxydeoxyguanosine formation in rat kidney to lipid peroxidation, glutathione level and relative organ weight after a single administration of potassium bromate.”, Jpn. J. Cancer Res, 82: 165–169, (1991).
  13. Lee, Y.S., Choi, J.Y., Park, M.K., Choi, E.M., Kasai, H., and Chung, M.H., “Induction of OH8Gua glycosylase in rat kidneys by potassium 186
  14. GU J Sci., 24(2):181-186 (2011)/ Serhat KESER1♠, Okkes YILMAZ2, Mehmet TUZCU2
  15. bromate (KBrO3), a renal oxidative carcinogen.”,
  16. Mutation Research, 364: 227–233, (1996).
  17. DeAngelo, A.B., George, M.H., Kilburn, S.R., Moore, T.M., and Wolf, D.C., “Carcinogenicity of potassium bromate administered in the drinking water to male B6C3F1 mice and F344/N rats.”, Toxicol. Pathol, 26: 587–594, (1998).
  18. Wolf, D.C., Crosby, L.M., George, M.H., Kilburn, S.R., Moore, T.M., Miller, R.T., and DeAngelo, A.B., “Time- and dose-dependent development of potassium bromate-induced tumors in male Fischer 344 rats.”, Toxicol. Pathol, 26: 724–729, (1998).
  19. Dobrzyn, A., and Ntambi, J.M., “The role of stearoyl-CoA desaturase in body weight regulation.”, Trends in Cardiovascular Medicine, 14(2): 77–81, (2004).
  20. Ntambi, J.M., and Miyazaki, M., “Regulation of stearoyl-CoA desaturases and role in metabolism.”, Progress in Lipid Research, 43: 91–104, (2004).
  21. Hardy, S., El-Assad, W., Przybytkowski, E., Joly, E., Prentki, M., and Langelier, Y., “Saturated fatty acids induced apoptosis in MDA-MB-231 breast cancer cells: a role for cardiolipin.”, Journal of Biological Chemistry, 278: 31861–31870, (2003).
  22. Hara, A., and Radin, N.S., “Lipid extraction of tissues with a low-toxicity solvent.”, Analytical Biochemistry, 90: 420-426, (1978).
  23. Christie, W.W., “Gas chromatography and lipids”, The Oil Press, Glasgow, (1992).
  24. Wang, Z., Zou, J., Cao, K., Hsieh, T.C., Huang, Y.Z., and Wu, J.M., “Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels.”, Int. J. Mol. Med, 16: 533–540, (2005).
  25. Milde, J., Elstner, E.F., and Grabmann, J., “Synergistic effects of polyphenols and carotenoids on human low-density lipoprotein oxidation.”, Mol. Nutr. Food Res, 51: 956–961, (2007).
  26. Baur, J.A., and Sinclair, D.A., “Therapeutic potential of resveratrol: the in vivo evidence.”, Nat. Rev. Drug Discovery, 5: 493–506, (2006).
  27. Park, C.E., Kim, M.J., Lee, J.H., Min, B.I., Bae, H., Choe, W., Kim, S.S., and Ha, J., “Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase.”, Exp. Mol. Med, 39: 222–229, (2007).
  28. Ray, P.S., Maulik, G., Cordis, G.A., Bertelli, A.A.E., Bertelli, A., and Das, D.K., “The red wine antioxidant resveratrol protects isolated rat hearts fro ischemia reperfusion injury.”, Free Rad. Biol. Med, 27: 160–169, (1999).
  29. Stojanovic, S., Sprinz, H., and Brede, O., “Efficiency and mechanism of the antioxidant action of trans-resveratrol and its analogues in the radical liposome oxidation.”, Arch. Biochem. Biophys, 391: 79–89, (2001).
  30. Oak, M.H., Bedour, J.E., and Schini-Kerth, V.B., “Antiangiogenic properties of natural polyphenols from red wine and green tea.”, J. Nutr. Biochem, 16: 1–8, (2005).
  31. Baur, J.A., Pearson, K.J., Price, N.L., Jamieson, H.A., Lerin, C., Kalra, A., Prabhu, V.V., Allard, J.S., Lopez-Lluch, G., Lewis, K., Pistell, P.J., Poosala, S., Becker, K.G., Boss, O., Gwinn, D., Wang, M.Y., Ramaswamy, S., Fishbein, K.W., Spencer, R.G., Lakatta, E.G., Le Couteur, D., Shaw, R.J., Navas, P., Puigserver, P., Ingram, D.K., de Cabo, R., and Sinclair, D.A., “Resveratrol improves health and survival of mice on a high- calorie diet.”, Nature, 444: 337–342, (2006).
  32. Ajmo, J.M., Liang, X.M., Rogers, C.Q., Pennock, B., and You, M., “Resveratrol alleviates alcoholic fatty liver in mice.”, American Journal of Physiology-Gastrointestinal and Liver Physiology, 295(4): 833-842, (2008).
  33. Gnoni, G.V., and Paglialonga, G., “Resveratrol inhibits fatty acid and triacylglycerol synthesis in rat hepatocytes.”, European Journal of Clinical Investigation, 39(3), 211-218, (2009).
  34. Nakamura, M.T., and Nara, T.Y., “Structure, function, and dietary regulation of Delta 6, Delta 5, and Delta 9 desaturases.”, Annual Review of Nutrition, 24: 345-376, (2004).
  35. Cheul Kim, Y., and Nitambi, M., “Regulation of Stearoyl-CoA desaturase genes; role in cellular metabolism and preadipocyte differentiation.”, Biochemical and Biophysical Research Communications, 266: 1-4, (1999).
  36. Ntambi, J.M., “Regulations of Stearoyl-CoA desaturase by polyunsaturated fatty acids and cholesterol.”, Journal of Lipid Research, 409: 1549-1558, (1999).
  37. Douillet, C., Chancerelle, Y., Cruz, C., Maroncles, C., Kergonou, J.F., Renaud, S., Ciavatti, M., “High dosage vitamin E effect on oxidative status and serum-lipids distribution in streptozotocin-induced diabetic rats.”, Biochemical Medicine and Metabolic Biology, 50: 265-276, (1993).
  38. Yiin, S.J., and Lin, T.H., “Lead-catalysed peroxidation of essential unsaturated fatty acid.”, Biological Trace Element Research, 50(2): 167- 172, (1995).
  39. Cohen, P, Zhao, C, Cai, X., Montez, J.M., Rohani, S.C., Feinstein, P., Mombaerts, P., and Friedman, J.M., “Selective deletion of leptin receptor in neurons leads to obesity.”, Journal of Clinical Investigation, 108: 1113–1121, (2001).
  40. Baur, J.A., Pearson, K.J., Price, N.L., Jamieson, H.A., Lerin, C., Kalra, A., Prabhu, V.V., Allard, J.S., Lopez-Lluch, G., Lewis, K., Pistell, P.J., Poosala, S., Becker, K.G., Boss, O., Gwinn, D., Wang, M.Y., Ramaswamy, S., Fishbein, K.W., Spencer, R.G., Lakatta, E.G., Le Couteur, D., Shaw, R.J., Navas, P., Puigserver, P., Ingram, D.K., de Cabo, R., and Sinclair, D.A., “Resveratrol improves health and survival of mice on a high- calorie diet.”, Nature, 444: 337–342, (2006).
  41. Yiin, S.J., and Lin, T.H., “Lead-catalysed peroxidation of essential unsaturated fatty acid.”, Biological Trace Element Research, 50(2): 167- 172, (1995).