Ehlers Danlos Syndrome in a Kangal Breed Puppy

Abstract

A Kangal breed, 1,5 month-old, male dog was presented with the complaints of spontaneous skin lesions on lateral left hindlimb and different location of body. In general examination, the dog had lymphadenopathy on submabdibular and popliteal lenf nodules, but the other parametres were normal. At inspection, the dog was lateral recumbence and a ulserative skin wound was seen on lateral side of tarsal joints. There was also a right eye microphthalmia and bragnathia inferior. In addition, there were foldings on extremity skins, swellings with diffuse fluctuation in both hindlimbs and prolapsing in dorsally pelvis skin. In the palpation, hipermobility and laxity of tarsal and carpal joints, general skin hiperextensibility and fragility was determined. Radiological examination revealed bilaterally tarsal and carpal joints space widened. In ultrasonographic examination of fluctuation regions, with unclear limits, anechoic and some corpuscular hiperreflective particles in heterogeneous areas was detected. Skin extensibility index rate was found as %21(dog normal SEI- Skin Extensibility Index rate %8-15). Histologically, it was identified that epidermis and dermis thickness were markedley diminished, dermal collagen fibers was indicated characteristic of thin and pale staining, irregularly organized and the spaces between fibers was increased. The dog owner was informed about the pathology that there was no therapy for the disease, but consistent medical applications could allow to live long lives for the puppy. Reporting to clinical and histopathological findings of Ehler Danlos syndrome in a Kangal breed puppy was aimed with the case.