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Dergiler / Journal of Istanbul Veterinary Sciences / 2026 / Cilt: 6 Sayı: 1

Determination of estrogen receptor, progesterone receptor and epidermal growth factor receptor in canine vaginal tumors and vaginal fold prolapse: A preliminary study

Zeynep Günay Uçmak(Istanbul University-Cerrahpaşa, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Istanbul, Turkey)0000-0003-2530-1291
Atila Ateş(ISTANBUL UNIVERSITY-CERRAHPASA, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF BASIC SCIENCES VETERINARY MEDICINE, DEPARTMENT OF BIOCHEMISTRY)0000-0002-9013-930X
Özge Erdoğan Bamaç(ISTANBUL UNIVERSITY-CERRAHPASA, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF PRE-CLINICAL SCIENCES, DEPARTMENT OF PATHOLOGY)0000-0002-0352-4841
Hazal Öztürk Gürgen(ISTANBUL UNIVERSITY-CERRAHPASA, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF PRE-CLINICAL SCIENCES, DEPARTMENT OF PATHOLOGY)0000-0003-2748-6189
İsmail Kırşan(ISTANBUL UNIVERSITY-CERRAHPASA, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF CLINICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNECOLOGY)0000-0003-0780-0118
Çağatay Tek(ISTANBUL UNIVERSITY-CERRAHPASA, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF CLINICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNECOLOGY)0000-0002-6429-658X
Çağla Nur Küçükbekir(ISTANBUL UNIVERSITY-CERRAHPASA, INSTITUTE OF GRADUATE PROGRAMS)0000-0002-9687-1702
İbrahim Kurban(ISTANBUL UNIVERSITY-CERRAHPASA, VETERİNER FAKÜLTESİ VOCATIONAL SCHOOL, DEPARTMENT OF PLANT AND ANIMAL PRODUCTION, HORSE TRAINING TEACHING PR.)0000-0002-8391-905X
Sayfa
35–41
Yayın Tarihi
2022-04-30
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Further studies are needed to discuss these pathologies with healthy bitches in terms of steroid receptor and EGFR levels in both vaginal tissue and blood sera.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Eight dogs with a vaginal mass were incorporated into the study.
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Temel Bulgular & Veri:According to the vaginal examination (vaginoscopy, exfoliative vaginal cytology) and histopathology, the groups were designed as vaginal fold prolapse (Group VFP; n=3) and vaginal tumor (Group VT; n=5).
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Sonuç & Katkı:Further studies are needed to discuss these pathologies with healthy bitches in terms of steroid receptor and EGFR levels in both vaginal tissue and blood sera.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Canine · leiomyoma · leiomyosarcoma

Abstract

Eight dogs with a vaginal mass were incorporated into the study. According to the vaginal examination (vaginoscopy, exfoliative vaginal cytology) and histopathology, the groups were designed as vaginal fold prolapse (Group VFP; n=3) and vaginal tumor (Group VT; n=5). Vaginal tissue samples were homogenized. Tissue homogenates were analyzed with enzyme-linked immunosorbent assay (ELISA) to determine the levels of estrogen receptor (ER), progesterone receptor (PR), and epidermal growth factor receptor (EGFR). The mean ER level was significantly higher in group VT compared to the group VFP (P<0.05). However, PR and EGFR levels did not showed significance related to the groups (P>0.05). In conclusion, significant differences were obtained between the bitches with VT and VFP related to ER levels although both groups have pathological conditions. Further studies are needed to discuss these pathologies with healthy bitches in terms of steroid receptor and EGFR levels in both vaginal tissue and blood sera.

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Bu Makaleye Atıf Yap

Uçmak, Z. G., Ateş, A., Bamaç, Ö. E., Gürgen, H. Ö., Kırşan, İ., Tek, Ç., Küçükbekir, Ç. N., Kurban, İ. (2022). Determination of estrogen receptor, progesterone receptor and epidermal growth factor receptor in canine vaginal tumors and vaginal fold prolapse: A preliminary study. Journal of Istanbul Veterinary Sciences, Cilt: 6 Sayı: 1, 35–41. https://doi.org/10.30704/http-www-jivs-net.1066060

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