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Dergiler / Journal of Istanbul Veterinary Sciences / 2026 / Cilt: 10 Sayı: 1

Chromium, cadmium and lead in feline mammary neoplasms

Zeynep Günay Uçmak(Istanbul University-Cerrahpaşa, Faculty of Veterinary Medicine, Department of Obstetrics and Gynaecology, Istanbul, Turkey)0000-0003-2530-1291
Lora Koenhemsi(ISTANBUL UNIVERSITY-CERRAHPASA, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF CLINICAL SCIENCES, DEPARTMENT OF INTERNAL MEDICINE)0000-0002-4979-170X
Duygu Tarhan(BAHCESEHIR UNIVERSITY, SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF BIOPHYSICS)0000-0002-0878-5709
Fatma Ateş(Department of Biophysics, Faculty of Medicine, Bezmialem University)0000-0001-6429-9572
Funda Yıldırım(ISTANBUL UNIVERSITY-CERRAHPASA, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF PRE-CLINICAL SCIENCES, DEPARTMENT OF PATHOLOGY)0000-0001-9755-8198
Hazal Öztürk Gürgen(ISTANBUL UNIVERSITY-CERRAHPASA, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF PRE-CLINICAL SCIENCES, DEPARTMENT OF PATHOLOGY)0000-0003-2748-6189
İbrahim Kurban(Vocational School of Veterinary Medicine, İstanbul University-Cerrahpaşa)0000-0002-8391-905X
İsmail Kırşan(ISTANBUL UNIVERSITY-CERRAHPASA, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF CLINICAL SCIENCES, DEPARTMENT OF OBSTETRICS AND GYNECOLOGY)0000-0003-0780-0118
Alev Meltem Ercan(İSTANBUL ÜNİVERSİTESİ-CERRAHPAŞA, CERRAHPAŞA TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, BİYOFİZİK ANABİLİM DALI)0000-0002-4533-4907
M. Erman Or(ISTANBUL UNIVERSITY-CERRAHPASA, FACULTY OF VETERINARY MEDICINE, DEPARTMENT OF CLINICAL SCIENCES, DEPARTMENT OF INTERNAL MEDICINE)0000-0002-8764-1956
Sayfa
101–110
Yayın Tarihi
2026-04-30
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

The findings of this study indicate that tissue Cr, Cd, and Pb concentrations are associated with clinicopathological features related to the prognosis in feline mammary tumor, which is a suitable natural model for human breast cancer research.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:This study aimed to evaluate concentrations of heavy metals (chromium (Cr), cadmium (Cd), and lead (Pb)) in feline mammary tissues, and to correlate their concentration with clinical and pathological findings with reported impact in prognosis.
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Temel Bulgular & Veri:In this study, a total of 62 tissue samples from 15 female cats with malignant epithelial tumors (MET; n=40 masses from 10 cats) and non-neoplastic benign lesions (H&D; n=22 masses from 5 cats) were evaluated.
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Sonuç & Katkı:The findings of this study indicate that tissue Cr, Cd, and Pb concentrations are associated with clinicopathological features related to the prognosis in feline mammary tumor, which is a suitable natural model for human breast cancer research.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:cadmium · chromium · lead

Özet

This study aimed to evaluate concentrations of heavy metals (chromium (Cr), cadmium (Cd), and lead (Pb)) in feline mammary tissues, and to correlate their concentration with clinical and pathological findings with reported impact in prognosis. In this study, a total of 62 tissue samples from 15 female cats with malignant epithelial tumors (MET; n=40 masses from 10 cats) and non-neoplastic benign lesions (H&D; n=22 masses from 5 cats) were evaluated. Tissue Cr, Cd, and Pb levels in Group MET were not significantly different from those in Group H&D (P>0.05). In Group MET, Cr in Grade 1 (n=9) tended to be higher than in Grade 2 (n=9) and Grade 3 (n=22), but it could not reach the significance (P=0.054). Also, tissue Cr levels were not significantly related to the tumor sizes (P>0.05). The highest tissue Cd level was observed in T1 (0-2 cm), which was significantly higher than in T2 (2-3 cm) (P<0.01). Also, Cd levels in T2 were lower than in T3 (> 3cm) (P<0.05). Additionally, tissue Pb levels in T3 were significantly higher than those in T2 and T1 (P<0.05). Tissue Cr levels were significantly higher in the presence of ulceration on the tumor (P<0.05), while tissue Cd and Pb levels were not significantly different (P>0.05). The findings of this study indicate that tissue Cr, Cd, and Pb concentrations are associated with clinicopathological features related to the prognosis in feline mammary tumor, which is a suitable natural model for human breast cancer research.

Abstract

This study aimed to evaluate concentrations of heavy metals (chromium (Cr), cadmium (Cd), and lead (Pb)) in feline mammary tissues, and to correlate their concentration with clinical and pathological findings with reported impact in prognosis. In this study, a total of 62 tissue samples from 15 female cats with malignant epithelial tumors (MET; n=40 masses from 10 cats) and non-neoplastic benign lesions (H&D; n=22 masses from 5 cats) were evaluated. Tissue Cr, Cd, and Pb levels in Group MET were not significantly different from those in Group H&D (P>0.05). In Group MET, Cr in Grade 1 (n=9) tended to be higher than in Grade 2 (n=9) and Grade 3 (n=22), but it could not reach the significance (P=0.054). Also, tissue Cr levels were not significantly related to the tumor sizes (P>0.05). The highest tissue Cd level was observed in T1 (0-2 cm), which was significantly higher than in T2 (2-3 cm) (P<0.01). Also, Cd levels in T2 were lower than in T3 (> 3cm) (P<0.05). Additionally, tissue Pb levels in T3 were significantly higher than those in T2 and T1 (P<0.05). Tissue Cr levels were significantly higher in the presence of ulceration on the tumor (P<0.05), while tissue Cd and Pb levels were not significantly different (P>0.05). The findings of this study indicate that tissue Cr, Cd, and Pb concentrations are associated with clinicopathological features related to the prognosis in feline mammary tumor, which is a suitable natural model for human breast cancer research.

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Bu Makaleye Atıf Yap

Uçmak, Z. G., Koenhemsi, L., Tarhan, D., Ateş, F., Yıldırım, F., Gürgen, H. Ö., Kurban, İ., Kırşan, İ., Ercan, A. M., Or, M. E. (2026). Chromium, cadmium and lead in feline mammary neoplasms. Journal of Istanbul Veterinary Sciences, Cilt: 10 Sayı: 1, 101–110. https://doi.org/10.30704/http-www-jivs-net.1903078

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