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Dergiler / Journal of Basic and Clinical Health Sciences / 2026 / Volume: 10 Issue: 2

The Protective Potential of Cardamom in an Experimental Bladder Ischemia-Reperfusion Model

Büşra Çitil Demirci0000-0001-8168-4392
Işıl Yağmur(KAHRAMANMARAŞ SÜTÇÜ İMAM ÜNİVERSİTESİ)0000-0002-7009-4693
Ergul Belge Kurutas(KAHRAMANMARAS SUTCU IMAM UNIVERSITY)0000-0002-6653-4801
Sayfa
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Yayın Tarihi
2026-05-31
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Further clinical studies are needed to better understand the bladder-protective effects of cardamom.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Bladder ischemia-reperfusion (I/R) injury causes tissue damage through oxidative stress, inflammation, and cellular dysfunction.
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Temel Bulgular & Veri:The I/R group underwent 30 minutes of ischemia followed by 30 minutes of reperfusion.
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Sonuç & Katkı:Further clinical studies are needed to better understand the bladder-protective effects of cardamom.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Elettaria cardamomum · Bladder · Ischemia-Reperfusion

Abstract

Bladder ischemia-reperfusion (I/R) injury causes tissue damage through oxidative stress, inflammation, and cellular dysfunction. Cardamom (Elettaria cardamomum) has shown protective effects on various tissues due to its antioxidant and anti-inflammatory properties. However, its effects on bladder I/R injury have not been adequately investigated. This study aimed to investigate the biochemical and histopathological protective effects of cardamom extract against bladder I/R injury. Wistar albino rats were divided into three groups: I/R group, sham group, and cardamom treatment group. The I/R group underwent 30 minutes of ischemia followed by 30 minutes of reperfusion. The cardamom group received 50 mg/kg of cardamom extract via gavage 24 hours before the I/R process. Bladder tissues were collected for biochemical analysis of oxidative stress markers (MDA, SOD, CAT) and histopathological examination. In the cardamom-treated group, MDA levels were significantly lower, and SOD and CAT enzyme activities were significantly higher compared to the I/R group (p < 0.05). Histopathological analysis showed prominent inflammation, edema, and disruption of epithelial integrity in the I/R group, while the cardamom group exhibited notably reduced tissue damage and better-preserved epithelial integrity. Cardamom extract demonstrated a protective effect against bladder I/R injury by reducing oxidative stress and suppressing inflammation. Further clinical studies are needed to better understand the bladder-protective effects of cardamom.

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Bu Makaleye Atıf Yap

Demirci, B. Ç., Yağmur, I., Kurutas, E. B. (2026). The Protective Potential of Cardamom in an Experimental Bladder Ischemia-Reperfusion Model. Journal of Basic and Clinical Health Sciences, Volume: 10 Issue: 2. https://doi.org/10.30621/jbachs.1702938

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