Dergiler / Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi / 2026 / Cilt: 22 Sayı: 64

Doğal Antimikrobiyal Maddelerin Cerrahi Sütürlerin Özelliklerine Etkisi

The Effect of Natural Antimicrobial Agents on the Characteristics of Surgical Sutures

Elif Alyamaç Seydibeyoğlu(IZMIR KATIP CELEBI UNIVERSITY)0000-0002-6438-0511
Ayşe Işık(IZMIR KATIP CELEBI UNIVERSITY)0000-0001-7444-8359
Sayfa
11–20
Yayın Tarihi
2020-01-24
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Sütürlerin yüzeyleri taramalı elektron mikroskobuyla incelenerek uzun daldırma ve kurutma işlemleri sonrası kaplama malzemesinin yüzeye güçlü bir şekilde tutunduğu gözlemlenmiştir.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Cerrahi girişim uygulanan vücut bölgelerinde, ameliyat sonrası cerrahi alan enfeksiyonları (CAE) ortaya çıkar.
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Temel Bulgular & Veri:Bu çalışmada, CAE’nin üstesinden gelmek amacıyla farklı tipteki cerrahi sütürler doğal antimikrobiyal ajanlarla kaplanmıştır ve bu ajanların cerrahi sütürlerin morfolojik ve mekanik özelliklerine olan etkisi değerlendirilmiştir.
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Sonuç & Katkı:Sütürlerin yüzeyleri taramalı elektron mikroskobuyla incelenerek uzun daldırma ve kurutma işlemleri sonrası kaplama malzemesinin yüzeye güçlü bir şekilde tutunduğu gözlemlenmiştir.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Biyopolimer · Kitosan · Aloe Vera

Özet

Cerrahi girişim uygulanan vücut bölgelerinde, ameliyat sonrası cerrahi alan enfeksiyonları (CAE) ortaya çıkar. Cerrahide yaralar sütür olarak bilinen iplik benzeri materyallerle kapatılır. Bazı sütür tipleri, CAE'ye sebep olan bakterilerin çoğalmasına neden olmaktadır. Sütür kaynaklı enfeksiyonun önüne geçmek için antimikrobiyallerle kaplama yapılır. Bu çalışmada, CAE’nin üstesinden gelmek amacıyla farklı tipteki cerrahi sütürler doğal antimikrobiyal ajanlarla kaplanmıştır ve bu ajanların cerrahi sütürlerin morfolojik ve mekanik özelliklerine olan etkisi değerlendirilmiştir. Bu bağlamda, doğal bir polimer olan kitosan antimikrobiyal özelliğe sahip olması sebebiyle seçilmiştir ve kitosan yine doğal antimikrobiyal ajan olan aloe vera ve zeytin yaprağı ekstresi ile beraber asetik asit çözeltisi içerisinde ultrason teknolojisi kullanılarak karıştırılıp kaplama solüsyonu hazırlanmıştır. Doğal ajanların sinerjistik etkisini çalışmak için farklı konsantrasyonlarda hazırlanan kaplama solüsyonlarına multifilament ipek, multifilament poliester ve monofilament poliamid sütürler daldırılarak kaplama yapılmıştır. Fourier dönüşümlü kızılötesi spektroskopisi kullanılarak kaplanmış sütürlerin üzerindeki fonksiyonel gruplar belirlenmiştir. Sütürlerin yüzeyleri taramalı elektron mikroskobuyla incelenerek uzun daldırma ve kurutma işlemleri sonrası kaplama malzemesinin yüzeye güçlü bir şekilde tutunduğu gözlemlenmiştir. Ayrıca yapılan mekanik testler sonucunda kaplama işleminin sütür mekanik özelliklerini arttırdığı tespit edilmiştir.

Abstract

Surgical site infections (SSI) occur after the surgery in body parts where the operation took place. In surgeries, wounds are closed by thread-like materials known as sutures. Some types of sutures may promote bacteria proliferation which is one of the leading causes of the SSI. Sutures undergo coating procedure to prevent infection occurrence. In this study, different types of surgical sutures were coated with natural antimicrobial agents to evaluate their effect on morphological and mechanical properties of the surgical sutures. In this context, due to its antimicrobial ability, chitosan was selected and dissolved in acetic acid solution with other natural antimicrobial agents (aloe vera and olive leaf extract) through ultrasound technology. Multifilament silk, multifilament polyester, and monofilament polyamide sutures were then dipped into those solutions prepared at different concentrations in order to study the synergistic effect of antimicrobial agents. Fourier transform infrared spectroscopy with attenuated total reflectance (FTIR-ATR) was performed to identify the functional groups on the surface of the coated sutures. Suture surfaces were also analyzed by scanning electron microscope (SEM) to observe the coating on the surface of sutures. Strong adhesion was determined between the suture surface and the coating material after long duration of dipping and drying procedure. It was also found that the coating process increased the mechanical properties of the sutures.

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Bu Makaleye Atıf Yap

Seydibeyoğlu, E. A., Işık, A. (2020). Doğal Antimikrobiyal Maddelerin Cerrahi Sütürlerin Özelliklerine Etkisi. Dokuz Eylül Üniversitesi Mühendislik Fakültesi Fen ve Mühendislik Dergisi, Cilt: 22 Sayı: 64, 11–20. https://doi.org/10.21205/deufmd.2020226402

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