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Dergiler / Meyve Bilimi / 2026 / Cilt: 13 Sayı: 1

Turunçgil Kabuğu Esansiyel Yağlarının Uçucu Bileşenleri ve Ana Bileşenlerin Moleküler Bağlanma Analizleri

Volatile Composition and Molecular Docking Analysis of Major Constituents from Citrus Peel Essential Oils

Sercan Önder(ISPARTA UYGULAMALI BİLİMLER ÜNİVERSİTESİ, ZİRAAT FAKÜLTESİ, TARIMSAL BİYOTEKNOLOJİ BÖLÜMÜ, TARIMSAL BİYOTEKNOLOJİ PR.)0000-0002-8065-288X
Murat Mutlucan(ISPARTA UYGULAMALI BİLİMLER ÜNİVERSİTESİ, GÜL VE AROMATİK BİTKİLER UYGULAMA VE ARAŞTIRMA MERKEZİ)0000-0002-6990-277X
Kerem Mertoğlu(UŞAK ÜNİVERSİTESİ, ZİRAAT FAKÜLTESİ, BAHÇE BİTKİLERİ BÖLÜMÜ)0000-0002-0490-9073
Sabri Erbaş(ISPARTA UYGULAMALI BİLİMLER ÜNİVERSİTESİ, ZİRAAT FAKÜLTESİ, TARLA BİTKİLERİ BÖLÜMÜ)0000-0003-0691-6127
Muhammet Tonguç(ISPARTA UYGULAMALI BİLİMLER ÜNİVERSİTESİ, ZİRAAT FAKÜLTESİ, TARIMSAL BİYOTEKNOLOJİ BÖLÜMÜ)0000-0003-1292-2910
Sayfa
88–101
Yayın Tarihi
2026-07-20
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Moleküler kenetlenme analizleri, D-limonen ve L-limonen enantiomerlerinin antibakteriyel hedef GyrB'ye kıyasla antifungal hedef CYP51'e daha yüksek bağlanma afinitesi gösterebileceğini ortaya koymuştur.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Turunçgil kabuğu atıkları, uçucu bileşenleri nedeniyle katma değerli ürünler için umut vadeden bir kaynaktır.
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Temel Bulgular & Veri:Uçucu yağ verimleri önemli ölçüde farklılık gösterip ve en yüksek ve en düşük verimler sırasıyla tatlı portakal (%0.67) ve greyfurt (%0.07)’dan elde edilmiştir.
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Sonuç & Katkı:Moleküler kenetlenme analizleri, D-limonen ve L-limonen enantiomerlerinin antibakteriyel hedef GyrB'ye kıyasla antifungal hedef CYP51'e daha yüksek bağlanma afinitesi gösterebileceğini ortaya koymuştur.
🔬Tür:Araştırma Makalesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Turunçgiller · Turunçgil kabuğu · Turunçgil atıkları

Özet

Turunçgil kabuğu atıkları, uçucu bileşenleri nedeniyle katma değerli ürünler için umut vadeden bir kaynaktır. Bu çalışmada, altı turunçgil türünün kabuklarından hidrodistilasyon yöntemiyle elde edilen uçucu yağ bileşimleri GC-MS analizi ile karakterize edilmiştir. Uçucu yağ verimleri önemli ölçüde farklılık gösterip ve en yüksek ve en düşük verimler sırasıyla tatlı portakal (%0.67) ve greyfurt (%0.07)’dan elde edilmiştir. Toplam 67 uçucu bileşik tanımlanmış ve limonen (%57.74-90.34) tüm yağ örneklerinde baskın bileşen olmuştur. Monoterpen hidrokarbonlar tüm türlerde baskın kimyasal sınıfı oluştururken, oksijenli monoterpenler ve seskiterpenler türe bağlı olarak varyasyon göstermiştir. Özellikle tatlı portakal yüksek linalool içeriği gösterirken, pomelo nispeten daha yüksek seskiterpen hidrokarbon içeriği ile öne çıkmıştır. Hiyerarşik kümeleme analizi ve Venn diyagramı değerlendirildiğinde kemotaksonomik farklılaşmalarına yardımcı olan hem ortak hem de türe özgü bileşiklerin bulunduğu ortaya konmuştur. Moleküler kenetlenme analizleri, D-limonen ve L-limonen enantiomerlerinin antibakteriyel hedef GyrB'ye kıyasla antifungal hedef CYP51'e daha yüksek bağlanma afinitesi gösterebileceğini ortaya koymuştur. Bu çalışma, turunçgil türlerinin sınıflandırılmasında uçucu bileşenler ve kullanımları ile potansiyel uygulamaları hakkında değerli bilgiler sağlamaktadır.

Abstract

Citrus peel waste is a promising source of value-added products because of its volatile constituents. In this study, essential oil compositions extracted by hydrodistillation from peels of six Citrus species were characterized by GC-MS analysis. Essential oil yields varied significantly and the highest and the lowest yields were obtained from sweet orange (0.67%) and grapefruit (0.07%), respectively. A total of 67 volatile compounds were identified, and limonene (57.74-90.34%) was the dominant constituent in all oil samples. Monoterpene hydrocarbons constituted the predominant chemical class in all species, while oxygenated monoterpenes and sesquiterpenes showed species-dependent variation. In particular, sweet orange showed a high linalool content, while pomelo exhibited relatively higher sesquiterpene hydrocarbon content. Hierarchical cluster analysis and Venn diagram evaluation revealed the presence of both common and species-specific compounds helping their chemotaxonomic differentiation. Molecular docking analyses suggested that D-limonene and L-limonene enantiomers may exhibit higher binding affinity toward the antifungal target CYP51 than toward antibacterial target GyrB. This study provides valuable information for volatile compositions and uses in classification of Citrus species along with their potential applications.

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Bu Makaleye Atıf Yap

Önder, S., Mutlucan, M., Mertoğlu, K., Erbaş, S., Tonguç, M. (2026). Turunçgil Kabuğu Esansiyel Yağlarının Uçucu Bileşenleri ve Ana Bileşenlerin Moleküler Bağlanma Analizleri. Meyve Bilimi, Cilt: 13 Sayı: 1, 88–101. https://doi.org/10.51532/meyve.1935913

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