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Dergiler / Experimed / 2022 / Volume: 12 Issue: 3

Evaluating the Long-Term Outcomes of Medical and Surgical Treatments in Fibrostenotic Crohn’s Disease Patients Treated with Anti-TNF/Biologic Therapy

Çağatay Ak(NİĞDE EĞİTİM ARAŞTIRMA HASTANESİ)0000-0002-2474-873X
Süleyman Sayar(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ ÜMRANİYE EĞİTİM ARAŞTIRMA HASTANESİ GASTROENTEROLOJİ BÖLÜMÜ)0000-0001-7089-6082
Resul Kahraman(SAĞLIK BİLİMLERİ ÜNİVERSİTESİ ÜMRANİYE EĞİTİM ARAŞTIRMA HASTANESİ GASTROENTEROLOJİ BÖLÜMÜ)0000-0001-5534-0860
Kamil Ozdil(SAĞLIK BİLİMERİ ÜNİVERSİTESİ ÜMRANİYE EĞİTİM ARAŞTIRMA HASTANESİ GASTROENTEROLOJİ BÖLÜMÜ)0000-0003-2556-3064
Sayfa
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Yayın Tarihi
2022-12-31
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Also, hypoalbuminemia may be a marker indicating a surgical decision

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Amaç & Hipotez:Objective: This study analyzed the follow-up findings on hospitalization requirements and clinical activities for fibrostenotic Crohn’s disease (CD) patients who received biological/anti-TNF treatment without undergoing surgery as well as CD patients who were treated medically and surgically.
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Temel Bulgular & Veri:Results: The study was consisted of 117 patients receiving anti-TNF therapy.
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Sonuç & Katkı:Also, hypoalbuminemia may be a marker indicating a surgical decision
🔬Tür:Clinical Research
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Crohn Disease · Anti-TNF Therapy · Surgical Therapy

Abstract

Objective: This study analyzed the follow-up findings on hospitalization requirements and clinical activities for fibrostenotic Crohn’s disease (CD) patients who received biological/anti-TNF treatment without undergoing surgery as well as CD patients who were treated medically and surgically. Materials and Methods: This study compared the Harvey-Bradshaw scores, control colonoscopy results, and hospitalization times regarding the long-term follow-ups for fibrostenotic CD patients who’ve undergone surgery and for those who only received medical treatment. In addition, the study analyzed the factors associated with disease activation. Results: The study was consisted of 117 patients receiving anti-TNF therapy. Patients who underwent surgery for stenotic CD had a lower one year Harvey-Bradshaw score and shorter hospitalization regarding their long-term follow-up compared to those who did not undergo surgery. Patients who underwent surgery had a lower albumin level (p < 0.001) and developed perianal CD (p = 0.046) less than those who had not undergone surgery. C-reactive protein elevation (p = 0.024) and smoking (p < 0.001) have been associated with disease activity, and the absence of granuloma (p = 0.003) and neural plexitis (p = 0.006) on the surgical specimen was found to be associated with disease activation. Conclusion: Surgical treatment is seen to improve the quality of life and result in fewer hospitalizations for fibrostenotic CD patients. Also, hypoalbuminemia may be a marker indicating a surgical decision

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Bu Makaleye Atıf Yap

Ak, Ç., Sayar, S., Kahraman, R., Ozdil, K. (2022). Evaluating the Long-Term Outcomes of Medical and Surgical Treatments in Fibrostenotic Crohn’s Disease Patients Treated with Anti-TNF/Biologic Therapy. Experimed, Volume: 12 Issue: 3. https://doi.org/10.26650/experimed.1183920

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