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Dergiler / Experimed / 2026 / Volume: 14 Issue: 1

Effects of GDF-15 Level in Patients with Membranous Nephropathy

Aıda Adıkozalova(Institute of Graduate Studies in Health Sciences, Istanbul University)0000-0003-2897-3624
Sebahat Usta Akgül(Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University)0000-0003-0176-3344
Erol Demir(Division of Nephrology, Department of Internal Diseases, Istanbul Faculty of Medicine)0000-0003-0128-5645
Hayriye Şentürk Çiftçi(Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University)0000-0003-3507-482X
Fatma Savran Oğuz(Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University)0000-0002-6018-8936
Halil Yazıcı(Division of Nephrology, Department of Internal Diseases, Istanbul Faculty of Medicine)0000-0003-2526-3483
Çiğdem Kekik Çınar(Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University)0000-0003-2098-381X
Sayfa
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Yayın Tarihi
2024-04-24
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: GDF-15 level may be used as a biomarker to predict the progression of MN rather than a diagnostic biomarker.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Nephrotic syndrome is the most frequent cause of membranous nephropathy (MN) in adults.
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Temel Bulgular & Veri:Growth differentiation factor (GDF)-15 is a cytokine released under stress and associated with increased incidence of chronic kidney disease and/or decreased renal function in conditions such as diabetic nephropathy, IgA nephropathy, lupus nephritis, and primary MN.
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Sonuç & Katkı:Conclusion: GDF-15 level may be used as a biomarker to predict the progression of MN rather than a diagnostic biomarker.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Membranous nephropathy · GDF-15 · ELISA

Abstract

Objective: Nephrotic syndrome is the most frequent cause of membranous nephropathy (MN) in adults. Growth differentiation factor (GDF)-15 is a cytokine released under stress and associated with increased incidence of chronic kidney disease and/or decreased renal function in conditions such as diabetic nephropathy, IgA nephropathy, lupus nephritis, and primary MN. The diagnosis of MN is made by biopsy, which is an invasive procedure. A non-invasive biomarker is needed for timely and risk-free diagnosis. This study aimed to estimate the GDF-15 level in patients with MN to determine if it can be used as a noninvasive biomarker for the diagnosis of MN. Materials and Methods: The study included 88 patients with MN. Sera were obtained from peripheral blood collected from the patients. GDF-15 levels were analyzed using enzyme-linked immunosorbent assay (ELISA). Results: GDF-15 level was high in older patients that in younger patients. The glomerular filtration rate was low in patients with increased GDF-15 levels. Furthermore, a decrease in GDF-15 levels was observed in patients in remission. Conclusion: GDF-15 level may be used as a biomarker to predict the progression of MN rather than a diagnostic biomarker.

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Bu Makaleye Atıf Yap

Adıkozalova, A., Akgül, S. U., Demir, E., Çiftçi, H. Ş., Oğuz, F. S., Yazıcı, H., Çınar, Ç. K. (2024). Effects of GDF-15 Level in Patients with Membranous Nephropathy. Experimed, Volume: 14 Issue: 1. https://doi.org/10.26650/experimed.1403563

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