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Dergiler / Experimed / 2026 / Volume: 14 Issue: 2

Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus

Derya Cansız(Istanbul Medipol University, Faculty of Medicine, Department of Biochemistry)0000-0002-6274-801X
Merih Beler(MARMARA UNIVERSITY, INSTITUTE OF HEALTH SCIENCES)0000-0002-3828-4630
İsmail Ünal(Istanbul Medipol University, Faculty of Medicine, Department of Biochemistry)0000-0002-8664-3298
Gizem Eğilmezer(MARMARA UNIVERSITY, INSTITUTE OF HEALTH SCIENCES)0000-0002-1231-5232
Zülal Mızrak(MARMARA UNIVERSITY, INSTITUTE OF HEALTH SCIENCES)0009-0004-7647-7267
Semanur Işıkoğlu(MARMARA UNIVERSITY, INSTITUTE OF HEALTH SCIENCES)0009-0003-9779-2867
Efruz İrem Akkuş(ISTANBUL UNIVERSITY, CERRAHPAŞA SCHOOL OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, MEDICAL DEPARTMENT OF BIOLOGY)0000-0001-8504-2602
Birsay Gümrü(Marmara University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology)0000-0002-7734-4755
Şebnem Erçalık Yalçınkaya(Marmara University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology)0000-0003-2924-1935
Ebru Emekli Alturfan(Marmara University, Faculty of Dentistry, Department of Biochemistry)0000-0003-2419-8587
Sayfa
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Yayın Tarihi
2024-08-26
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Conclusion: The results revealed that the salivary oxidant-antioxidant balance was disrupted in parallel with the increase in TF activity in patients with OLP.

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Amaç & Hipotez:Objective: The aim of our study was to investigate salivary tissue factor (TF) activity and oxidant-antioxidant status, which is an important defense system, in saliva samples collected from patients with oral lichen planus (OLP), and to determine the relationship between the antioxidant system and TF activity in OLP.
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Temel Bulgular & Veri:Materials and Methods: Saliva samples were collected from patients with OLP (n=20) and healthy subjects (n=13).
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Sonuç & Katkı:Conclusion: The results revealed that the salivary oxidant-antioxidant balance was disrupted in parallel with the increase in TF activity in patients with OLP.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Oral lichen planus · tissue factor · oxidative stress

Abstract

Objective: The aim of our study was to investigate salivary tissue factor (TF) activity and oxidant-antioxidant status, which is an important defense system, in saliva samples collected from patients with oral lichen planus (OLP), and to determine the relationship between the antioxidant system and TF activity in OLP. Materials and Methods: Saliva samples were collected from patients with OLP (n=20) and healthy subjects (n=13). TF activity, lipid peroxidation (LPO), nitric oxide (NO), glutathione (GSH) levels, glutathione S-transferase (GST), and superoxide dismutase (SOD) activities were measured. Results: NO levels and GST activities were increased, whereas GSH levels and SOD activities were decreased, when compared with healthy subjects in the saliva samples collected from patients with OLP. In addition, TF activity was increased in the OLP group compared with the control group. Conclusion: The results revealed that the salivary oxidant-antioxidant balance was disrupted in parallel with the increase in TF activity in patients with OLP.

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Bu Makaleye Atıf Yap

Cansız, D., Beler, M., Ünal, İ., Eğilmezer, G., Mızrak, Z., Işıkoğlu, S., Akkuş, E. İ., Gümrü, B., Yalçınkaya, Ş. E., Alturfan, E. E. (2024). Altered Tissue Factor Activity and Disrupted Oxidant-Antioxidant Status in Saliva of Patients with Oral Lichen Planus. Experimed, Volume: 14 Issue: 2. https://doi.org/10.26650/experimed.1461284

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