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Dergiler / Experimed / 2024 / Volume: 14 Issue: 3

Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene

Didem Seven(Department of Medical Genetics, Yeditepe University School of Medicine)0000-0003-3406-5905
Ömer Faruk Bayrak(Department of Medical Genetics, Yeditepe University School of Medicine)0000-0001-7562-6604
Sayfa
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Yayın Tarihi
2024-12-19
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Further investigation is required to validate the role and potential of this agent as a therapeutic target.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Objective: Prostate cancer is the fifth leading cause of death worldwide.
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Temel Bulgular & Veri:Transcriptomic profiling in prostate cancer enhances our understanding of the disease at the molecular level, facilitating more accurate diagnosis and personalized treatment choices, and ultimately improving patient outcomes.
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Sonuç & Katkı:Further investigation is required to validate the role and potential of this agent as a therapeutic target.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Prostate cancer · transcriptomic profiling · RPH3AL

Abstract

Objective: Prostate cancer is the fifth leading cause of death worldwide. Treatment modalities for advanced prostate cancer include androgen deprivation therapy (ADT), chemotherapy, radiotherapy, and targeted therapy. Transcriptomic profiling in prostate cancer enhances our understanding of the disease at the molecular level, facilitating more accurate diagnosis and personalized treatment choices, and ultimately improving patient outcomes. Identifying new therapeutic biomarkers for prostate cancer is important for developing targeted therapy options. This study aimed to elucidate the pathways associated with prostate cancer and identify differentially expressed genes. Materials and Methods: An RNA-seq dataset, GSE210205, was used to reveal transcriptomic differences between prostate cancer and benign prostate cell lines. GEO2R analysis, GSEA analysis, WebGestalt analysis, and GEPIA analyses were performed to generate differentially expressed genes, identify enriched pathways, and investigate gene expression in prostate cancer. Results: Pathways such as Wnt/β-catenin signaling, DNA IR-induced double-strand breaks, cellular response via ATM, Type II interferon signaling, and TGF-β signaling were enriched in the prostate cancer transcriptome. Among the five most over-expressed genes, RPH3AL was the most prominent. Conclusion: RPH3AL is a potential biomarker for prostate cancer based on transcriptomic profiling. Further investigation is required to validate the role and potential of this agent as a therapeutic target.

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Bu Makaleye Atıf Yap

Seven, D., Bayrak, Ö. F. (2024). Determining Prostate Cancer-Related Pathways and the Role of the RPH3AL Gene. Experimed, Volume: 14 Issue: 3. https://ajindex.com/articles/1116525

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