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Dergiler / Experimed / 2026 / Volume: 15 Issue: 1

The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease

Gözde Ceylan(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF BIOCHEMISTRY)0000-0003-3397-9676
Nazan Karagöz Sakallı(Bakirkoy Mazhar Osman Mental Health and Neurological Diseases Training and Research Hospital, Department of Neurology)0000-0002-7172-954X
Hacer Eroglu Icli(Bakirkoy Mazhar Osman Mental Health and Neurological Diseases Training and Research Hospital, Department of Biochemistry)0000-0002-9775-1710
Canan Basaran Kucukgergin(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF BIOCHEMISTRY)0000-0002-1797-5889
Semra Dogru Abbasoglu(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF BIOCHEMISTRY)0000-0003-3467-9763
Pervin Vural(ISTANBUL UNIVERSITY, İSTANBUL FACULTY OF MEDICINE, DEPARTMENT OF BASIC MEDICAL SCIENCES, DEPARTMENT OF BIOCHEMISTRY)0000-0001-6462-7388
Sayfa
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Yayın Tarihi
2025-04-16
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Conclusion: Alongside the established core AD biomarkers, serum total tau and NFL are promising biomarkers for AD, reflecting additional pathological changes during the disease.

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Amaç & Hipotez:Objective: Alzheimer’s disease (AD) is a neurodegenerative disorder that causes dementia and accounts for 50-75% of all cases.
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Temel Bulgular & Veri:Materials and Methods: Blood samples were obtained from 86 AD patients (33 mild, 29 moderate, and 24 severe AD) and 30 controls.
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Sonuç & Katkı:Conclusion: Alongside the established core AD biomarkers, serum total tau and NFL are promising biomarkers for AD, reflecting additional pathological changes during the disease.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Alzheimer’s disease · Serum · Biomarker

Abstract

Objective: Alzheimer’s disease (AD) is a neurodegenerative disorder that causes dementia and accounts for 50-75% of all cases. Since cerebrospinal fluid sampling (CSF) is an invasive procedure, there is a need for non- or less invasive alternatives to identify new biomarkers that reflect the underlying AD pathology. Materials and Methods: Blood samples were obtained from 86 AD patients (33 mild, 29 moderate, and 24 severe AD) and 30 controls. Serum total tau, neurofilament light polypeptide (NFL), neurogranin, chitinase-3-like protein 1 (YKL-40), and fatty acid-binding protein 3 (FABP-3) were measured using enzymelinked immunosorbent assay (ELISA). Results: Serum total tau and NFL levels were higher in AD patients compared to controls, whereas neurogranin, YKL-40, and FABP-3 levels remained unchanged. In the receiver operating characteristic (ROC) curve analysis, the sensitivity and specificity for total tau alone (cut-off point: 71.5 pg/mL) were 79.1% and 76.7% (Area under the curve (AUC): 0.865; p<0.001), while the sensitivity and specificity for NFL alone (cut-off point: 1.835 pg/mL) were 66.3% and 66.7% (AUC: 0.693; p=0.002). When total tau and NFL were concomitantly evaluated, the AUC was 0.848 (p<0.001). Conclusion: Alongside the established core AD biomarkers, serum total tau and NFL are promising biomarkers for AD, reflecting additional pathological changes during the disease.

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Bu Makaleye Atıf Yap

Ceylan, G., Sakallı, N. K., Icli, H. E., Kucukgergin, C. B., Abbasoglu, S. D., Vural, P. (2025). The Evaluation of Serum Total Tau, NFL, Neurogranin, YKL-40, and FABP-3 as Screening Biomarkers for Alzheimer’s Disease. Experimed, Volume: 15 Issue: 1. https://doi.org/10.26650/experimed.1587358

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