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Dergiler / Trakya University Journal of Natural Sciences / 2023 / Volume: 24 Issue: 2

THE ROLE OF ANTICOAGULANT, THROMBOLYTIC, AND FIBRINOLYTIC ACTIVITIES IN THE PREVENTION OF PERITONEAL ADHESION

Gizem Deynez(GAZI UNIVERSITY)0000-0003-0324-0192
Ece Miser Salihoğlu(GAZI UNIVERSITY)0000-0003-0681-3566
İpek Süntar(GAZİ ÜNİVERSİTESİ)0000-0003-4201-1325
Sayfa
—
Yayın Tarihi
2023-10-15
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Bu bağlamda bu çalışma, yukarıda bahsedilen aktivitelerin patofizyolojik süreçlerini özetlemeyi, peritoneal adezyon modelindeki önemini vurgulamayı ve özellikle doğal ürünlerin araştırılması açısından değerlendirme yöntemlerini açıklamayı amaçlamaktadır.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Peritoneal adezyon cerrahi, peritoneal yaralanma, peritonit, hipoksi ve iskeminin bir sonucu olarak ortaya çıkar.
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Temel Bulgular & Veri:Nitekim karın içi yapışıklığa karşı yeni ve etkili ajanlar bulmak için birçok çalışma yapılmıştır.
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Sonuç & Katkı:Bu bağlamda bu çalışma, yukarıda bahsedilen aktivitelerin patofizyolojik süreçlerini özetlemeyi, peritoneal adezyon modelindeki önemini vurgulamayı ve özellikle doğal ürünlerin araştırılması açısından değerlendirme yöntemlerini açıklamayı amaçlamaktadır.
🔬Tür:Deneysel Tarla Denemesi
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Adhesion · Anticoagulant · Postoperative abdominal adhesion

Özet

Peritoneal adezyon cerrahi, peritoneal yaralanma, peritonit, hipoksi ve iskeminin bir sonucu olarak ortaya çıkar. Cerrahi travma, inflamasyon, oksidasyon, pıhtılaşma, fibrinoliz, hücre proliferasyonu ve apoptozu içeren birçok patofizyolojik sürece neden olur. Karın içi operasyonlardan sonra, düşük fibrinolitik aktiviteye bağlı olarak periton yüzeyinde adezyon dokusu oluşabilir. Bu, uygun şekilde oluşturulmuş fibrin yapıları yerine kalıcı aşırı adezyon doku bantları ile sonuçlanabilir. Bu nedenle, antikoagülan, trombolitik ve fibrinolitik aktiviteler peritoneal adezyonu önlemede anahtar role sahiptir. Nitekim karın içi yapışıklığa karşı yeni ve etkili ajanlar bulmak için birçok çalışma yapılmıştır. Bu nedenle nedenlerinin, gelişim süreçlerinin ve inceleme tekniklerinin ortaya konulması, bu tür bilimsel çalışmaların tasarlanması ve yürütülmesi açısından oldukça önemlidir. Bu bağlamda bu çalışma, yukarıda bahsedilen aktivitelerin patofizyolojik süreçlerini özetlemeyi, peritoneal adezyon modelindeki önemini vurgulamayı ve özellikle doğal ürünlerin araştırılması açısından değerlendirme yöntemlerini açıklamayı amaçlamaktadır.

Abstract

Peritoneal adhesion occurs as a result of surgery, peritoneal injury, peritonitis, hypoxia, and ischemia. Surgical trauma causes many pathophysiological processes which include inflammation, oxidation, coagulation, fibrinolysis, cell proliferation, and apoptosis. After intra-abdominal operations, the adhesion tissue may occur on the peritoneal surface due to low fibrinolytic activity. This may result in permanent excessive adhesion tissue bands instead of properly formed fibrin structures. Therefore, anticoagulant, thrombolytic, and fibrinolytic activities have a key role in preventing peritoneal adhesion. Indeed, several studies have been conducted to find out new and effective agents against intra-abdominal adhesion. Thus, revealing the causes, development processes, and investigation techniques are highly important for designing and conducting such scientific studies. In this context, this study aims to summarize the pathophysiological processes of above-mentioned activities and to emphasize their importance in the peritoneal adhesion model as well as to explain the evaluation methods, particularly in terms of the investigation of natural products.

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Bu Makaleye Atıf Yap

Deynez, G., Salihoğlu, E. M., Süntar, İ. (2023). THE ROLE OF ANTICOAGULANT, THROMBOLYTIC, AND FIBRINOLYTIC ACTIVITIES IN THE PREVENTION OF PERITONEAL ADHESION. Trakya University Journal of Natural Sciences, Volume: 24 Issue: 2. https://doi.org/10.23902/trkjnat.1309119

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