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Dergiler / İstanbul Journal of Pharmacy / 2000 / Volume: 33 Issue: 0

DRUG RELEASE FROM PEG SUPPOSITORY BASES AND FROM THEIR COMBINATION WITH POLYMERS

1 M. Akhtar, 2 N. Akhtar, 3 M. Ahmad 4 A.s. Arıf, 5 Pervaız A. Shah
Sayfa
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Yayın Tarihi
2015-09-08
DOI
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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

Key words: Ethylene glycol, Diethylene glycol, Tragacanth, Metronidazole, Suppository bases.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:In vitro investigation was conducted to evaluate the drug (Metronidazole) release from the formulation containing "PEG SUPPOSITORIES BASES" and its combination with CMC and PVP.
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Temel Bulgular & Veri:When the percentage of the dmg release was upto 65%, the rate of release vs time was linear but with combinations (with PVP and CMC) the rate was only linear upto 50% drug release at 37 °C.
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Sonuç & Katkı:Key words: Ethylene glycol, Diethylene glycol, Tragacanth, Metronidazole, Suppository bases.
🔬Tür:Research Article
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Ethylene glycol · Diethylene glycol · Tragacanth

Özet

In vitro investigation was conducted to evaluate the drug (Metronidazole) release from the formulation containing "PEG SUPPOSITORIES BASES" and its combination with CMC and PVP. The experiments were conducted at various temperatures and at rectal pH. When the percentage of the dmg release was upto 65%, the rate of release vs time was linear but with combinations (with PVP and CMC) the rate was only linear upto 50% drug release at 37 °C. Linear relationship was also observed between average molecular weight of the bases upto 50% release rate at temperatures 37 °C, 40 °C, and 45 °C. Different drug release was not only dependant on the average molecular weight but also the proportions of various PEG bases. Key words: Ethylene glycol, Diethylene glycol, Tragacanth, Metronidazole, Suppository bases.

Abstract

In vitro investigation was conducted to evaluate the drug (Metronidazole) release from the formulation containing "PEG SUPPOSITORIES BASES" and its combination with CMC and PVP. The experiments were conducted at various temperatures and at rectal pH. When the percentage of the dmg release was upto 65%, the rate of release vs time was linear but with combinations (with PVP and CMC) the rate was only linear upto 50% drug release at 37 "C. Linear relationship was also observed between average molecular weight of the bases upto 50% release rate at temperatures 37 "C, 40 "C, and 45 "C. Different drug release was not only dependant on the average molecular weight but also the proportions of various PEG bases.

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Bu Makaleye Atıf Yap

Akhtar, 1. M., Akhtar, 2. N., Arıf, 3. M. A. 4. A., Shah, 5. P. A. (2015). DRUG RELEASE FROM PEG SUPPOSITORY BASES AND FROM THEIR COMBINATION WITH POLYMERS. İstanbul Journal of Pharmacy, Volume: 33 Issue: 0. https://ajindex.com/articles/1108124

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Kaynakça (13)

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