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Dergiler / Hacettepe Journal of Biology and Chemistry / 2023 / Cilt: 51 Sayı: 4

COMPARISION OF THE GLIO-PROTECTIVE EFFECTS OF BIOPOLYMER COATED ELECTROSPUN SCAFFOLDS

Ece BATTALOĞLU
Zehra Gül MORÇİMEN
Aylin ŞENDEMİR
Sayfa
327–340
Yayın Tarihi
2023-11-07
DOI
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Yapay Zeka Hızlı Bakış & Çıkarımlar

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⚡ TL;DR(1 Cümlede Hızlı Çıkarım)

It was found that 5µg/mL LPS concentration induced gliosis and hyaluronic acid-coated PCL scaffolds have shown a protective effect on gliosis.

📌 3 Maddede Bu Makale

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Amaç & Hipotez:Gliosis is a condition that plays a negative role in various neurological pathologies.
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Temel Bulgular & Veri:First, in vitro gliosis model was obtained by inducing U-87 MG cells with LPS and IFN-γ.
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Sonuç & Katkı:It was found that 5µg/mL LPS concentration induced gliosis and hyaluronic acid-coated PCL scaffolds have shown a protective effect on gliosis.
🔬Tür:Modelleme & Sayısal Simülasyon
📍Kapsam:Genişletilmiş Akademik Örneklem
⚙️Değişkenler:Gliosis · neural tissue engineering · electrospinning

Abstract

Gliosis is a condition that plays a negative role in various neurological pathologies. In this study, it was aimed to obtain and compare the glio-protective effects of electrospun fibrous scaffolds coated by different biopolymers. First, in vitro gliosis model was obtained by inducing U-87 MG cells with LPS and IFN-γ. The optimized model was applied to U-87 MG cells grown on polycaprolactone (PCL), hyaluronic acid (HA) coated, gelatin coated, and collagen coated PCL scaffolds. Immunofluorescent (IF) staining was performed with glial fibrillary acidic protein (GFAP) antibody to determine the level of gliosis. It was found that 5µg/mL LPS concentration induced gliosis and hyaluronic acid-coated PCL scaffolds have shown a protective effect on gliosis.

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Bu Makaleye Atıf Yap

BATTALOĞLU, E., MORÇİMEN, Z. G., ŞENDEMİR, A. (2023). COMPARISION OF THE GLIO-PROTECTIVE EFFECTS OF BIOPOLYMER COATED ELECTROSPUN SCAFFOLDS. Hacettepe Journal of Biology and Chemistry, Cilt: 51 Sayı: 4, 327–340. https://ajindex.com/articles/1016041

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Kaynakça (8)

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