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Journals / Journal of the Turkish Chemical Society, Section A: Chemistry / 2016 / Cilt: 3 - Sayı: 1

Bazı Beş, Altı ve Yedi Üyeli Heterohalkalardan Türetilen Sübstitü Kinolinon Ketonların Sentezi

Synthesis of substituted quinolinone ketones derived with some five, six and seven-membered heterocycles

Hany Mohamed HASSANIN, Magdy Ahmed IBRAHIM, Mohamed ABASS, Shimaa BADRAN

Pages
27–45
DOI
—

Abstract

The synthesis of a series of new quinolinyl ketones substituted with some five, six and seven-membered diaza-heterocycles is described. Efficient base or acid-catalyzed nucleophilic heterocyclization of 6-ethyl-4,5-dioxo-5,6-dihydro-4H-pyrano[3,2-c]quinoline-3-carboxaldehyde with a variety of nitrogen and/or carbon 1,2-, 1,3-, and 1,4-binucleophiles afforded the target ketones in good yields. The structure of all new products was established on basis of their spectral and analytical data.

Özet

Bazı beş, altı ve yedi üyeli diaza-heterohalkalarla sübstitüe edilmiş bir seri yeni kinolinil ketonların sentezi bildirilmiştir. 6 etil-4, 5-dihidro-5, 6-dihidro-4H-pirano [3,2-c] kinolin-3-karbosaldehidin bir seri azot ve/veya 1,2- 1,3- ve 1,4- ketonları iyi verimlerle oluşturmuştur. Bütün yeni ürünlerin yapıları spektral ve analitik verilere dayanarak ortaya konmuştur.