Lipiodol chemoembolization and additional tamoxifen and verapamil as chemosensitizers in unresectable hepatocellular carcinoma with immunohistochemically P-glycoprotein positive case

Hasan ÜSTÜN,Melek ÜSTÜN,Timur SİNDEL,Saim YILMAZ,Hakan BOZCUK,Gülten KARPUZOĞLU,Burhan SAVAŞ

Abstract

This report describes the treatment of an advance hepatocellular carcinoma case vvhich has immunohistochemically proven P-glycoprotein positive cells, by chemoembolization and additional tamoxifen and verapamil as chemosensitizers. Chemotherapy resistance is a major problem in the treatment of patients with hepatocellular carcinoma and P-glycoprotein contributes to the resistance. Detection of P-glycoprotein positively by immunohistochemistry may affect therapy modalities in patients with hepatocellular carcinoma.

Özet

Keywords: Erişkin,İmmünohistokimya,Erkek,Kemoembolizasyon, terapötik,İlaç direnci, neoplazm,Karsinom, hepatosellüler,P-glikoprotein