Journals / Türk Üroloji Dergisi/Turkish Journal of Urology / 2004 / Cilt: 30 - Sayı: 1
The diagnostic efficacy of digital rectal examination (DRE), prostate specific antigen (PSA), transrectal ultrasound of prostate, prostate specific antigen density (PSAD), age related PSA and free/total PSA in the prostate cancer
- Pages
- 40–44
- DOI
- —
Abstract
Introduction: We investigate the diagnostic efficacy of digital rectal examination, prostate spccifıc antigen, transrectal ultrasound of prostate, prostate specific antigen density, age related PSA and free/total PSA in the prostate cancer. Materials and Methods: Between 1998 and 2002, we performed TRUS guided prostate biopsies to 233 patients (age 43-80, median 68) with suspicious digital rectal examination and/or PSA>4 ng/ml. We detected prostate cancer in 56 patients. The overall accuracy of abnormal TRUS fındings, PSAD 0,15 ng/ml/cc, age related PSA and F/T PSA (0,20 cut-off) were determined. Results: Cancer detection rate were; Only DRE: 0%, only PSA: 7.89%, DRE and PSA: 52%, DRE and PSA>10: 72%, PSA and TRUS: 62.5%, DRE and PSA and TRUS: 76%, Normal DRE and PSA: 4-10, PSAD: 0.15 cut-off: 14%. in age related PSA 70-79,11 biopsies avoided and 2 cancers missed in 81 patients. When the f/t PSA 0.20 cut-off point taken into consideration, 85% sensitivity was detected. Conclusion: Highest accuracy rate was provided with DRE -PSA>10 and DRE-PSA-TRUS combination. PSAD, age related PSA and f/t PSA rate did not provide more Information in prostate cancer detection.
Özet
Prostat kanseri tanısında parmakla rektal inceleme (PRİ), prostat spesifik antijen (PSA), transrektal ultrasonografi (TRUS), PSA dansitesi (PSAD), yaşa göre PSA, serbest/total PSA (s/t PSA) oranının doğruluğunu araştırdık. 1998-2002 tarihleri arasında kliniğimize başvuran, şüpheli rektal inceleme ve/veya PSA>4 ng/ml bulguları bulunan, yaşları 42 ila 80 arasında değişen (ortalama 68) 233 hastaya transrektal ultrason eşliğinde prostat biyopsisi yapıldı. 56 hastada kanser saptandı. TRUS'ta anormal bulgu, PSAD> 0.15ng/ml/cc, (Oesterling ve arkadaşlarının referansları) yaşa-göre PSA aralığı, S/T PSA oranı 10 ve PRİ, PSA, TRUS üçlüsü en yüksek doğruluk oranı saptarken, PSAD yaşa göre PSA, s/t PSA oranı prostat kanseri saptamada ek bir üstünlük sağlamamıştır.