Journals / Ankara Üniversitesi Tıp Fakültesi Mecmuası / 1999 / Cilt: 52 Sayı: 4

Serum IL-6, IL-1a, TNF a Levels in Amyliodosis

AMİLOİDOZİSDE SERUM IL-6, IL-1a, TNFa DÜZEYLERİ

Pages
219–225
Publication Date
1999-04-01
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

We think that the determination of serum IL-6 levels will be usefull to diagnose secondary amyloidosis and amyloidosis due to FMF, during the follovving of the chronic infections, inflammatory diseases, malign diseases that may cause secondary amyloidosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Serum interleukin-6 (IL-6) interleukin-1 a (IL-la) tumor necrosis factor a (TNF a) levels vvere determined by ELISA in ali 32 patients suffering from primary amyloidosis, secondary amyloidosis and amyloidosis due to Familial Mediterranian Fever (FMF) and 20 healthy control group.
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Key Findings & Data:Serum IL-6 levels in ali patients vvere significantly higher than control group (p<0.00l), in secondary amyloidosis and amyloidosis due to FMF were significantly higher than primary amyloidosis and control group (p<0.01).
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Conclusion & Impact:We think that the determination of serum IL-6 levels will be usefull to diagnose secondary amyloidosis and amyloidosis due to FMF, during the follovving of the chronic infections, inflammatory diseases, malign diseases that may cause secondary amyloidosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Amiloidozis · interlökin- 6 · interlökin -la

Abstract

Serum interleukin-6 (IL-6) interleukin-1 a (IL-la) tumor necrosis factor a (TNF a) levels vvere determined by ELISA in ali 32 patients suffering from primary amyloidosis, secondary amyloidosis and amyloidosis due to Familial Mediterranian Fever (FMF) and 20 healthy control group. Serum IL-6 levels in ali patients vvere significantly higher than control group (p<0.00l), in secondary amyloidosis and amyloidosis due to FMF were significantly higher than primary amyloidosis and control group (p<0.01). There vvere no differences for IL-1 a and TNF a in ali groups (p>0.05). We think that the determination of serum IL-6 levels will be usefull to diagnose secondary amyloidosis and amyloidosis due to FMF, during the follovving of the chronic infections, inflammatory diseases, malign diseases that may cause secondary amyloidosis.

Özet

Primer amiloidozis, sekonder amiloidozis, Ailevi Akdeniz Ateşi'ne (FMF) bağlı amiloidozisli toplam 32 hasta ve 20 sağlıklı kontrol grubunda serum interlökin-6 (IL-6), interlökin-la (İL, la), tümör nekrozis faktör a (TNFa) düzeylerini ELISA yöntemiyle tayin ettik. Tüm hastalarda IL-6 düzeyleri kontrol grubuna göre (pFMF'e bağlı amiloidozisde ise primer amiloidozis ve kontrol grubuna göre (p<0.01) anlamlı derecede yüksek idi. Tüm gruplarda İL-la ve TNF a açısından farklılık yoktu (p>0.05). Biz serum IL-6 düzeylerinin tayininin sekonder amiloidozis ve FMF'e bağlı amiloidozis tanısında ve sekonder amiloidozise yol açabilen kronik infeksiyonlar, int'lamatuvar hastalıklar, malign hastalıkların takibi esnasında faydalı olacağını düşünmekteyiz. ),>

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Cite This Article

KAÇAR, S., KARATAN, O., TUTKAK, H. (1999). Serum IL-6, IL-1a, TNF a Levels in Amyliodosis. Ankara Üniversitesi Tıp Fakültesi Mecmuası, Cilt: 52 Sayı: 4, 219–225. https://ajindex.com/articles/982169

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