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Journals / Acta Veterinaria Eurasia / 2016 / Cilt: 42 Sayı: 2

Comparative Study of Erythrocyte Sedimentation Rate after Aminoglycoside and Aminocyclitol Treatment in Goats (Capra hircus)

Toncho DINEV
Dian KANAKOV
Georgi BEEV
Nikolina RUSENOVA
Stefan DENEV
Pages
186–189
Publication Date
2016-07-04
DOI
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⚡ TL;DR(Too Long; Didn't Read)

In conclusion the aminoglycosides, especially tobramycin and gentamicin, caused more severe alterations of ESR than the aminocyclitols.

📌 3 Key Takeaways

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Objective & Hypothesis:The aim of the present study was to follow up the erythrocyte sedimentation rate (ESR) in healthy female goats during and after 5-day parenteral treatment with amikacin (10 mg/kg), tobramycin (5 mg/kg), apramycin (20 mg/kg), gentamicin (4 mg/kg), kanamycin (10 mg/kg) and spectinomycin (20 mg/kg).
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Key Findings & Data:Gentamicin and tobramycin caused an initial increase followed by a significant decrease of ESR on the 5th day for gentamicin and the 10th day for tobramycin, respectively, followed by recovery after the treatment.
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Conclusion & Impact:In conclusion the aminoglycosides, especially tobramycin and gentamicin, caused more severe alterations of ESR than the aminocyclitols.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Amikacin · tobramycin · apramycin

Abstract

The aim of the present study was to follow up the erythrocyte sedimentation rate (ESR) in healthy female goats during and after 5-day parenteral treatment with amikacin (10 mg/kg), tobramycin (5 mg/kg), apramycin (20 mg/kg), gentamicin (4 mg/kg), kanamycin (10 mg/kg) and spectinomycin (20 mg/kg). Gentamicin and tobramycin caused an initial increase followed by a significant decrease of ESR on the 5th day for gentamicin and the 10th day for tobramycin, respectively, followed by recovery after the treatment. Reversely, amikacin and especially spectinomycin produced an increase of ESR without recovery several days post treatment. Kanamycin caused decrease of ESR on the 5th day without recovery in the subsequent days. Only apramycin did not give rise to increasing of ESR. In conclusion the aminoglycosides, especially tobramycin and gentamicin, caused more severe alterations of ESR than the aminocyclitols.

Özet

The aim of the present study was to follow up the erythrocyte sedimentation rate (ESR) in healthy female goats during and after 5-day parenteral treatment with amikacin (10 mg/kg), tobramycin (5 mg/kg), apramycin (20 mg/kg), gentamicin (4 mg/kg), kanamycin (10 mg/kg) and spectinomycin (20 mg/kg). Gentamicin and tobramycin caused an initial increase followed by a significant decrease of ESR on the 5th day for gentamicin and the 10th day for tobramycin, respectively, followed by recovery after the treatment. Reversely, amikacin and especially spectinomycin produced an increase of ESR without recovery several days post treatment. Kanamycin caused decrease of ESR on the 5th day without recovery in the subsequent days. Only apramycin did not give rise to increasing of ESR. In conclusion the aminoglycosides, especially tobramycin and gentamicin, caused more severe alterations of ESR than the aminocyclitols.

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Cite This Article

DINEV, T., KANAKOV, D., BEEV, G., RUSENOVA, N., DENEV, S. (2016). Comparative Study of Erythrocyte Sedimentation Rate after Aminoglycoside and Aminocyclitol Treatment in Goats (Capra hircus). Acta Veterinaria Eurasia, Cilt: 42 Sayı: 2, 186–189. https://ajindex.com/articles/980641

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References (10)

  1. Brion, N., Barge, J., Godefroy, I., Dromer, F., Dubois, C., Contrepois A., Carbon, C., 1984. Gentamicin, netilmicin, dibekacin, and amikacin nephrotoxicity and its relationship to tubular reabsorption in rabbits. Antimicrobial Agents and Chemotherapy 25, 168-172.
  2. Dhar, H., Shah, K., Ghongane, B., Rane, S., 2013. Nephroprotective activity of crocus sativus extract against gentamicin and/or ceftazidime-induced nephrotoxicity in rats. International Journal of Pharma and Bio Sciences 4, 864-870.
  3. Dinev, T., 2007. Comparative investigations on side effects, antimicrobial activity and pharmacokinetics of aminoglycosides and aminocyclitols in goats and goat´s isolated microorganisms. PhD Thesis, Trakia University, Stara Zagora, Bulgaria. Dinev, T., Kanakov, D., Zapryanova, D., 2005. Investigations on some biochemical and haematological parameters after tobramycin and amikacin treatment in female goats. Trakia Journal of Sciences 3, 14-16.
  4. Dowling, P., 2013. Amİnoglycosides and Aminocyclitols. In: Giguere, S. (Ed.), Antimicrobial Therapy in Veterinary Medicine, Ames, USA, pp. 233-256.
  5. Hottendorf, G., Gordon, L., 1980. Comparative low-dose nephrotoxicities of gentamicin, tobramycin, and amikacin. Antimicrobial Agents and Chemotherapy 18, 176-181.
  6. Lacy, M.K., Nicolau, D.P., Nightingale, C.H., Quintiliani, R., 1998. The Pharmacodynamics of Aminoglycosides. Clinical Infectious Diseases 27, 23-27.
  7. Lashev, L., Lasarova, S., 2001. Pharmacokinetics and sideeffects of gentamicin in healthy and Pseudomonas aeruginosa infected sheep. Journal of Veterinary Pharmacology and Therapeutics 24, 237-240.
  8. Liu, S., Ren, J., Xia, Q., Wu, X., Han, G., Ren, H., Yan, D., Wang, G., Gu, G., Li, J., 2013. Preliminary case-control study to evaluate diagnostic values of C-reactive protein and erythrocyte sedimentation rate in differentiating active Crohn’s disease from intestinal lymphoma, intestinal tuberculosis and Behcet’s syndrome. The American Journal of the Medical Sciences 346, 467-472.
  9. Mumtaz, F., Khaliq, T., Rahman, Z., Javed, I., Iftikhar, A., Aslam, B., Ali, A., Ahmad, Z., 2014. Effects of Rosa damascena mill flowers, Cichorium intybus linn roots and their mixtures on serum electrolytes and hematological parameters against gentamicin induced toxicity in albino rabbits. Indo American Journal of Pharmaceutical Research 4, 236-241.
  10. Novak, E., Gray, J.E., Pfeifer, R.T., 1974. Animal and human tolerance of high-dose intramuscular therapy with spectinomycin. The Journal of Infectious Dise