SavedAdd your journal

Journals / Turkish Journal of Veterinary and Animal Sciences / 2009 / Cilt: 33 - Sayı: 3

Comparative pharmacokinetics and PK/PD parameters of five aminoglycosides in goats

Toncho DINEV
Valentina URUMOVA
Mihni LYUTSKANOV
Lubomir LASHEV
Pages
223–228
Publication Date
2009-03-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The same interpretation could be made for the area under the curve/MIC90 ratio.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The pharmacokinetics of gentamicin, tobramycin, amikacin, kanamycin, and apramycin were investigated after single intravenous administration in goats. their antimicrobial activity against 30 strains of Staphylococcus aureus isolates from goats was also studied.
📊
Key Findings & Data:All 5 antibiotics showed a marked high in vitro antibacterial activity.
💡
Conclusion & Impact:The same interpretation could be made for the area under the curve/MIC90 ratio.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:aminoglycosides · pharmacokinetics · antibacterial action

Abstract

The pharmacokinetics of gentamicin, tobramycin, amikacin, kanamycin, and apramycin were investigated after single intravenous administration in goats. their antimicrobial activity against 30 strains of Staphylococcus aureus isolates from goats was also studied. On the base of the pharmacokinetic and pharmacodynamic data, a comparison between antibiotics was made. All 5 antibiotics showed a marked high in vitro antibacterial activity. The lowest MIC90 values were those of amikacin and the highest one was of kanamycin. The ratios of Cmax/MIC showed that amikacin has an advantage of providing the highest values of the concentration/MIC90 ratio, as well of the time providing bactericidal levels, followed by apramycin, whereas the other 3 antibiotics had comparable values, but lower than the first 2 antibiotics. The same interpretation could be made for the area under the curve/MIC90 ratio.

Özet

The pharmacokinetics of gentamicin, tobramycin, amikacin, kanamycin, and apramycin were investigated after single intravenous administration in goats. their antimicrobial activity against 30 strains of Staphylococcus aureus isolates from goats was also studied. On the base of the pharmacokinetic and pharmacodynamic data, a comparison between antibiotics was made. All 5 antibiotics showed a marked high in vitro antibacterial activity. The lowest MIC90 values were those of amikacin and the highest one was of kanamycin. The ratios of Cmax/MIC showed that amikacin has an advantage of providing the highest values of the concentration/MIC90 ratio, as well of the time providing bactericidal levels, followed by apramycin, whereas the other 3 antibiotics had comparable values, but lower than the first 2 antibiotics. The same interpretation could be made for the area under the curve/MIC90 ratio.

🔖

Cite This Article

DINEV, T., URUMOVA, V., LYUTSKANOV, M., LASHEV, L. (2009). Comparative pharmacokinetics and PK/PD parameters of five aminoglycosides in goats. Turkish Journal of Veterinary and Animal Sciences, Cilt: 33 - Sayı: 3, 223–228. https://ajindex.com/articles/122105

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Toutain, P.L., del Castillo, J.R., Bousquet-Mélou, A.: The pharmacokinetic-pharmacodynamic approach to a rational dosage regimen for antibiotics. Res. Vet. Sci., 2002; 73: 105-114.
  2. Haritova, A.M., Djeneva, H.A., Lashev, L.D., Sotirova., P.G., Gurov, B.I., Dyankov, V.N.: Pharmacokinetics of gentamicin and apramycin in turkeys, roosters and hens in the context of pharmacokinetic-pharmacodynamic relationships. J. Vet. Pharmacol. Ther., 2004; 27: 381-384.
  3. Mouton, J.W., Vinks, A.A.: Pharmacokinetic/pharmacodynamic modeling of antibacterials in vitro and in vivo using bacterial growth and kill kinetics: the minimum inhibitory concentration versus stationary concentration. Clin. Pharmacokinet, 2005; 44: 201-210
  4. Carbon, C., Contrepois, A., Lamotte-Barrillon, S.: Comparative distribution of gentamicin, tobramycin, sisomicin, netilmicin, and amikacin in interstitial fluid in rabbits. Antimicrob. Agents Chemother., 1978; 13: 368-372.
  5. Chung, M., Parravicini, L., Assael, B.M., Cavanna, G., Radwanski, E., Symchowicz, S.: Comparative pharmacokinetics of aminoglycoside antibiotics in guinea pigs. Antimicrob. Agents Chemother., 1982; 22: 1017-1021.
  6. Arret, B., Johnson, D.P., Kirshbaum, A.: Outline of details for microbiological assays of antibiotics: second revision. J. Pharm. Sci., 1971; 60: 1689-1694. CLSI: Methods for Dilution Antimicrobial Susceptibility Test for Bacteria That Grow Aerobically. Approved Standard M7- A3. Clinical Laboratory Standards Institute, Villanova, Pa. 1999.
  7. Brown, S.A., Riviere, J.E.: Comparative pharmacokinetics of aminoglycoside antibiotics. J. Vet. Pharmacol. Ther., 1991; 14: 1- 35. Uppal, R.P., Verma, S.P., Roy, R.K., Garg, S.K.: Pharmacokinetics of amikacin sulphate in goats. Indian J. Pharmacol., 1992; 24: 123-125.
  8. Garg, S.K., Verma, S.P., Uppal, R.P.: Pharmacokinetics of gentamicin following single-dose parenteral administration to goats. Br. Vet. J., 1995; 151: 453-458
  9. Abo El-Sooud, K.: Pharmacokinetics of amikacin in lactating goats. J. Vet. Med. A, 1999; 46: 239-246.
  10. Agrawal, A.K., Singh, S.D., Jayachandran, C.: Effect of fever on pharmacokinetics and dosage regimen of intramuscularly administered amikacin in goats. J. Vet. Sci., 2001; 2: 91-96.
  11. Agrawal, A.K., Singh, S.D., Jayachandran, C.: Comparative pharmacokinetics and dosage regimen of amikacin in afebrile and febrile goats. Indian J. Pharmacol., 2002; 34: 356-360.
  12. Lashev, L.D., Pashov, D.A., Marinkov, T.N.: Interspecies differences in the pharmacokinetics of kanamycin and apramyci