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Journals / Namık Kemal Tıp Dergisi / 2018 / Cilt: 6 Sayı: 3

Relationship Between Apnea Hypopnea Index, Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio in Patients With Obstructive Sleep Apnea Syndrome

Obstrüktif Uyku Apne Sendromlu Hastalarda Apne Hipopne İndeksi ile Nötrofil Lenfosit Oranı ve Platelet Lenfosit Oranının İlişkisi

Ayşe Karaoğullarından(Adana Numune Hastanesi, Adana, Türkiye)0000-0002-7120-4962
Osman Kürşat Arıkan
Sıdıka Deniz Yalım
Pages
83–87
Publication Date
2018-12-13
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusıons: In OSAS, there is a need for more comprehensive prospective and multi-centered study to better understand AHI and NLO, PLO relationship, Key words: Obstructive sleep apnea syndrome (OSAS), Polysomnography (PSG), neutrophil, lymphocyte

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Objective & Hypothesis:Abstract Aim: The aim of this study was to assess the association between apnea-hypopnea index (AHI) with neutrophil lymphocyte ratio (NLO) and platelet lymphocyte ratio (PLO) according to gender in patients with obstructive sleep apnea syndrome (OSAS) and to investigate whether PLO and NLO can be a predictor of disease severity before polysomnography.
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Key Findings & Data:Material and Method This study was designed as retrospective and cross-sectional, between March 2018 and April 2018, The patients who underwent PSG who were admitted to the Otorhinolaryngology outpatient clinic of Adana City Training and Research Hospital with the complaint of snoring and sleep apnea were evaluated.
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Conclusion & Impact:Conclusıons: In OSAS, there is a need for more comprehensive prospective and multi-centered study to better understand AHI and NLO, PLO relationship, Key words: Obstructive sleep apnea syndrome (OSAS), Polysomnography (PSG), neutrophil, lymphocyte
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Obstruktif uyku apne sendromu(OUAS) · Polisomnografi(PSG) · nötrofil

Abstract

Abstract Aim: The aim of this study was to assess the association between apnea-hypopnea index (AHI) with neutrophil lymphocyte ratio (NLO) and platelet lymphocyte ratio (PLO) according to gender in patients with obstructive sleep apnea syndrome (OSAS) and to investigate whether PLO and NLO can be a predictor of disease severity before polysomnography. Material and Method This study was designed as retrospective and cross-sectional, between March 2018 and April 2018, The patients who underwent PSG who were admitted to the Otorhinolaryngology outpatient clinic of Adana City Training and Research Hospital with the complaint of snoring and sleep apnea were evaluated. The study population was divided in to four groups: (i) first group described as; AHI 0-4.9 (ii) second group described as; 5-14.9 (iii) third group described as; AHI 15-29.9 and (iv) fourth group decribed as AHI ≥30 according to polyspmnography (PSG). Neutrophil, lymphocyte and platelet results were evaluated routinely from the blood count results. Results: Of the patients included in the study, 106 were male and 32 were female. The mean age was 45.3 (43,3 for males and 50,4 for females), the mean body mass index (BMI) was 30.1 (min: 19 - max: 51), the mean AHI was 23.7 (min: 0,3 max: 103), the mean PLO was 113,1 (male:111.2 , female: 119.5) and the mean NLO was 1,93 (male:1.99, female:1.72 ) . In our study, the highest PLO value was found in group 2 and the highest NLO value was found in group 3. The lowest NLO and PLO values were found in group 4, unlike the results from other studies. However, no statistically significant difference was found between the groups. Conclusıons: In OSAS, there is a need for more comprehensive prospective and multi-centered study to better understand AHI and NLO, PLO relationship, Key words: Obstructive sleep apnea syndrome (OSAS), Polysomnography (PSG), neutrophil, lymphocyte

Özet

Amaç: Bu çalışmanın amacı, OUAS’lı hastalarda, apne-hipopne indeksi (AHİ) ile nötrofil lenfosit oranı (NLO) ve platelet lenfosit oranı (PLO) arasındaki ilişkinin değerlendirilmesi ve NLO ile PLO nın polisomnografi öncesi hastalığın şiddeti ile ilgili bir belirteç olup olamayacağının incelenmesidir. Materyal ve Metot: : Calışmamız, retrospektif ve kesitsel bir calışma olup, çalışmamızda mart 2018- nisan 2018 tarihleri arasında Adana Şehir Eğitim ve Araştırma Hastanesi “Kulak Burun Boğaz polikliniğine horlama ve uyku apnesi şikayeti ile başvurup polisomnografi (PSG) yapılan hasta kayıtları değerlendirildi. PSG yapılan hastalardan Apne Hipopne indeksi (AHİ) 0-4.9 olan 1. Grup, AHİ 5-14.9 olan 2. Grup, 15-29.9 olan 3. grup ve AHİ >30 olan hasta 4. Grup olarak alındı. Calışmaya dahil edilen hastalardan rutin olarak istenen kan sayımı sonuclarından nötrofil, lenfosit ve platelet sonuçlarına bakıldı. Nötrofil, lenfosit ve plateletleri etkileyecek sistemik hastalığı olanlar çalışma dışı bırakıldı. Bulgular: Çalışmaya 138 hasta alındı. Çalışmaya dahil edilen hastaların 106 erkek, 26’sı kadındı. Genel yaş ortalaması 45,3 (erkeklerde 43,3; kadınlarda 50,4), vücut kitle endeksi (BMI) ortalaması 30.1 (min: 19 – max: 51) bulundu. AHİ ortalaması 23,7 (min: 0, 3-max:103), PLO ortalaması 113,1 (erkeklerde 111.2, kadınlarda 119.5) ve NLO ortalaması 1,93 ( erkeklerde 1.99, kadınlarda 1.72) olarak saptandı. Alt grupların demografik verileri, BMI, AHİ, PLO ve NLO değerleri Tablo-1-2 ve 3 te verildi. Bizim çalışmamızda en yüksek PLO değeri grup 2 de , en yüksek NLO değeri grup 3 te saptandı. En düşük NLO ve PLO değeri diğer çalışmalardaki sonuçlardan farklı olarak grup 4 te saptandı. Fakat gruplar arası incelemede istatistiksel olarak anlamlı bir farklılık saptanmadı. Hastalığın şiddeti ile PLO ve NLO arasında bir ilişki görülmedi. Bu durumun sebebi, hasta popülasyonunun görece az olması ya da gruplar arası dağılım eşitsizliği olabilir Sonuç: OUAS’de AHİ ile NLO ve PLO ilişkisini daha net anlayabilmek için daha kapsamlı prospektif ve cok merkezli calışmalara ihtiyac vardır

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Cite This Article

Karaoğullarından, A., Arıkan, O. K., Yalım, S. D. (2018). Relationship Between Apnea Hypopnea Index, Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio in Patients With Obstructive Sleep Apnea Syndrome. Namık Kemal Tıp Dergisi, Cilt: 6 Sayı: 3, 83–87. https://ajindex.com/articles/975224

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