Journals / Black Sea Journal of Health Science / 2023 / Cilt: 6 Sayı: 4

Seroprevalence of Toxoplasma, Rubella, and Cytomegalovirus Infections in Women of Childbearing Age Admitted to Kafkas University Health Research and Application Hospital: A Three-Year Evaluation

Kafkas Üniversitesi Sağlık Araştırma Ve Uygulama Hastanesi’ne Başvuran Doğurganlık Yaş Grubundaki Kadınlarda Toxoplasma gondii, Rubella ve Sitomegalovirus Seropozitifliği: Üç Yıllık Değerlendirme

Pages
719–725
Publication Date
2023-10-15
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our study results shows that the positivity rates of anti-Toxoplasma IgM and IgG were 0.5% and 19.4%, respectively; anti-Rubella IgM and IgG were 0.5% and 92.3%, respectively; and anti-CMV IgM and IgG were 0.5% and 99.9%, respectively.

📌 3 Key Takeaways

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Objective & Hypothesis:TORCH infections refer to a group of infections caused by pathogens such as Toxoplasma gondii, Rubella, Cytomegalovirus (CMV), Herpes simplex virus, and others, which can cross the maternal-fetal barrier and potentially adversely affect fetal development.
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Key Findings & Data:The results of a total of 2155 women aged 15-49 years, who were sent to our laboratory for the investigation of anti-Toxoplasma IgM and IgG, anti-Rubella IgM and IgG, and anti-CMV IgM and IgG serology between January 1, 2020, and December 1, 2022, were retrospectively analyzed.
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Conclusion & Impact:Our study results shows that the positivity rates of anti-Toxoplasma IgM and IgG were 0.5% and 19.4%, respectively; anti-Rubella IgM and IgG were 0.5% and 92.3%, respectively; and anti-CMV IgM and IgG were 0.5% and 99.9%, respectively.
🔬Design:Research Article
📍Scope:2020 Verileri
⚙️Variables:TORCH · Toxoplasma gondii · Rubella

Abstract

TORCH infections refer to a group of infections caused by pathogens such as Toxoplasma gondii, Rubella, Cytomegalovirus (CMV), Herpes simplex virus, and others, which can cross the maternal-fetal barrier and potentially adversely affect fetal development. This study aims to determine the seroprevalence of antibodies against Toxoplasma, Rubella, and CMV in women of childbearing age who have the potential to cause congenital infections. The results of a total of 2155 women aged 15-49 years, who were sent to our laboratory for the investigation of anti-Toxoplasma IgM and IgG, anti-Rubella IgM and IgG, and anti-CMV IgM and IgG serology between January 1, 2020, and December 1, 2022, were retrospectively analyzed. IgM and IgG antibodies in patient sera were detected using the Enzyme Linked Fluorescent Assay (ELFA-VIDAS, bioMérieux, France) method. Our study results shows that the positivity rates of anti-Toxoplasma IgM and IgG were 0.5% and 19.4%, respectively; anti-Rubella IgM and IgG were 0.5% and 92.3%, respectively; and anti-CMV IgM and IgG were 0.5% and 99.9%, respectively. A statistically significant difference was observed between age groups and Toxoplasma IgG seropositivity, with a statistically significant increase as age decreased (P<0.001). The high prevalence of CMV and Rubella IgG seropositivity in women of childbearing age in our region suggests that there may not be a need for screening in pregnant women for these factors. Additionally, considering the widespread practice of agriculture and livestock farming in our region, dietary habits involving a meat-based diet or undercooked meat consumption, and the relatively low rates of Toxoplasma seropositivity, we believe it would be appropriate for Toxoplasma to be included in the screening program.

Özet

TORCH enfeksiyonları, Toxoplasma gondii, Rubella, Sitomegalovirus (CMV), Herpes simpleks virüs ve diğer bazı patojenlerin neden olduğu, anne-fetal bariyeri geçebilen ve potansiyel olarak fetüsün gelişimini olumsuz etkileyebilen bir grup enfeksiyonu ifade etmektedir. Bu çalışmada, doğurganlık çağındaki kadınlarda konjenital enfeksiyonlara neden olma potansiyeline sahip Toksoplazma, Rubella ve CMV’ye karşı oluşan antikorların seroprevalansının belirlenmesi amaçlanmıştır. 1 Ocak 2020 ve 1 Aralık 2022 tarihleri arasında laboratuvarımıza anti-Toksoplazma IgM ve IgG, anti-Rubella IgM ve IgG, anti-CMV IgM ve IgG serolojisinin araştırılması amacı ile gönderilen doğurganlık çağındaki 15–49 yaş arası toplam 2155 kadına ait test sonuçları retrospektif olarak incelenmiştir. Hasta serumlarında, IgM ve IgG antikorları Enzyme Linked Fluorescent Assay (ELFA-VIDAS, bioMérieux, Fransa) yöntemi ile tespit edilmiştir. Çalışmamızda anti-Toksoplazma IgM pozitifliği %0,5, anti-Toksoplazma IgG pozitifliği %19,4; anti-Rubella IgM pozitifliği %0,5, anti-Rubella IgG pozitifliği %92,3; anti-CMV IgM pozitifliği %0,5, anti-CMV IgG pozitifliği ise %99,9 olarak tespit edilmiştir. Toksoplazma IgG seropozitifliği ile yaş grubu arasında istatistiksel olarak anlamlı bir farklılık olduğu ve yaşın azalması ile istatistiksel olarak arttığı tespit edilmiştir (p<0,001). Bölgemizde doğurganlık çağındaki kadınlarda yüksek oranda CMV IgG ve rubella IgG seropozitifliği saptanması, bu etkene karşı gebelerde taramaya gerek olmadığını göstermektedir. Ayrıca, bölgemizde tarım ve hayvancılığın yaygın olması, et ağırlıklı veya az pişmiş etle beslenme alışkanlığı ve Toksoplazma seropozitiflik oranlarının düşük düzeyde olması nedeniyle, tarama programında yer almasının uygun olacağını düşünmekteyiz.

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Cite This Article

ÖZGÜR, D. (2023). Seroprevalence of Toxoplasma, Rubella, and Cytomegalovirus Infections in Women of Childbearing Age Admitted to Kafkas University Health Research and Application Hospital: A Three-Year Evaluation. Black Sea Journal of Health Science, Cilt: 6 Sayı: 4, 719–725. https://ajindex.com/articles/968798

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