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Journals / Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi / 2023 / Cilt: 12 Sayı: 3

The Relationship Between Propionic Acid and Autism Spectrum Disorder

Propiyonik Asit ve Otizm Spektrum Bozukluğu İlişkisi

İbrahim Hakkı ÇAĞIRAN
Adviye Gülçin SAĞDIÇOĞLU CELEP
Pages
1464–1473
Publication Date
2023-09-26
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review was made to investigate the possible effects of PA.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Autism spectrum disorder (ASD) is a compound brain development disorder of uncertain etiology and pathophysiology.
📊
Key Findings & Data:In addition to environmental factors, genetic factors also affect the pathophysiology of ASD.
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Conclusion & Impact:This review was made to investigate the possible effects of PA.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Otizm · Hayvan modeli · Gıda katkı maddesi

Abstract

Autism spectrum disorder (ASD) is a compound brain development disorder of uncertain etiology and pathophysiology. In addition to environmental factors, genetic factors also affect the pathophysiology of ASD. Propionic acid (PA), which is used as a food additive and drug, can affect the genetic processes of brain development through the modulation of molecular pathways. Propionic acid causes the formation of ASD by causing mTOR/Gskβ, cytokine imbalance and disruption of developmental molecular pathways in the prenatal and neonatal period. This review was made to investigate the possible effects of PA.

Özet

Otizm spektrum bozukluğu (OSB), etiyolojisi ve patofizyolojisi belirsiz olan bileşik bir beyin gelişimi bozukluğudur. OSB patofizyolojisinde çevresel faktörlerin yanında genetik faktörler de etki etmektedir. Gıda katkı maddesi ve ilaç olarak kullanılmakta olan propiyonik asit (PA) moleküler yolların modülasyonu yoluyla beyin gelişiminin genetik süreçlerini etkileyebilmektedir. Propiyonik asit, prenatal ve neonatal dönemde mTOR/Gskβ, sitokin dengesizliğine ve gelişimsel moleküler yollarının bozulmasına neden olarak OSB’nin oluşmasına neden olur. Bu derleme, PA’nın olası etkilerini araştırmak amacıyla yapılmıştır.

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Cite This Article

ÇAĞIRAN, İ. H., CELEP, A. G. S. (2023). The Relationship Between Propionic Acid and Autism Spectrum Disorder. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, Cilt: 12 Sayı: 3, 1464–1473. https://ajindex.com/articles/962886

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