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Journals / Turkish Computational and Theoretical Chemistry / 2023 / Cilt: 7 Sayı: 3

Could Zingiber officinale plant be effective against Omicron BA.2.75 of SARS-CoV-2?

Handan SARAÇ
Ahmet DEMİRBAŞ
Burak TÜZÜN
Pages
42–56
Publication Date
2023-09-03
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

According to ADME/T results, these five molecules examined are suitable for use in human metabolism as drug molecules.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Zingiber officinale plant was examined in this study.
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Key Findings & Data:The activities of the determined chemical molecules against the SARS-CoV-2 Omicron variant were compared.
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Conclusion & Impact:According to ADME/T results, these five molecules examined are suitable for use in human metabolism as drug molecules.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Zingiber officinale · SARS-CoV-2 · omicron

Abstract

Zingiber officinale plant was examined in this study. The chemicals found in this plant were identified using the GC-MS method. The activities of the determined chemical molecules against the SARS-CoV-2 Omicron variant were compared. We focused to determine whether Zingiber officinale plant would be an inhibitor against Omicron of SARS-CoV-2 in silico. As a result of theoretical calculations, Zingiber officinale plant was found to contain many chemicals as a result of GC-MS analysis. These chemicals were detected one by one and their activity values were calculated for the SARS-CoV-2 virus. As a result, molecules with high activity were detected. ADME/T properties were investigated in order to examine the drug properties of molecules with high activity. According to ADME/T results, these five molecules examined are suitable for use in human metabolism as drug molecules.

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Cite This Article

SARAÇ, H., DEMİRBAŞ, A., TÜZÜN, B. (2023). Could Zingiber officinale plant be effective against Omicron BA.2.75 of SARS-CoV-2?. Turkish Computational and Theoretical Chemistry, Cilt: 7 Sayı: 3, 42–56. https://ajindex.com/articles/961461

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References (12)

  1. M. Boozari, H. Hosseinzadeh, Natural products for COVID‐19 prevention and treatment regarding to previous coronavirus infections and novel studies. Phytotherapy Research, 35(2) (2021) 864-876
  2. N. Gangal, V. Nagle, Y. Pawar, S. Dasgupta, Reconsidering traditional medicinal plants to combat COVID-19. AIJR Preprints, 34 (2020) 1-6
  3. J.N.M. Kanyinda, Coronavirus (COVID-19): a protocol for prevention and treatment (Covalyse®). European Journal of Medical and Health Sciences, (2020) 2(3)
  4. M. Mesri, S.S.E. Saber, M. Godazi, A.R. Shirdel, R. Montazer, H.R., Koohestani,. & N. Azizi, The effects of combination of Zingiber officinale and Echinacea on alleviation of clinical symptoms and hospitalization rate of suspected COVID-19 outpatients: a randomized controlled trial. Journal of Complementary and Integrative Medicine, 18(4) (2021) 775-781
  5. D. S. N. B. K. Prasanth, M. Murahari, V. Chandramohan, G. Bhavya, A. Lakshmana Rao, S.P. Panda,. T. Jaswitha, In-silico strategies of some selected phytoconstituents from Melissa officinalis as SARS CoV-2 main protease and spike protein (COVID-19) inhibitors. Molecular Simulation, 47(6) (2021) 457-470
  6. S. Banerjee, H.I. Mullick, J. Banerjee, A. Ghosh, Zingiber officinale:‘a natural gold’. Int J Pharmaceutical Bio-Sci, 2 (2011) 283-94
  7. K. Ghafoor, F. Al Juhaimi, M.M. Özcan, N. Uslu, E.E. Babiker, I.A.M. Ahmed, Total phenolics, total carotenoids, individual phenolics and antioxidant activity of ginger (Zingiber officinale) rhizome as affected by drying methods. Lwt, 126 (2020) 109354
  8. A. M. A. Ali, M. E. M. El-Nour, S. M. Yagi, Total phenolic and flavonoid contents and antioxidant activity of ginger (Zingiber officinale Rosc.) rhizome, callus and callus treated with some elicitors. Journal of genetic engineering and biotechnology, 16(2) (2018) 677-682
  9. Q. Q. Mao, X. Y. Xu, S. Y. Cao, R. Y. Gan, H. Corke, T. Beta, H. B. Li, Bioactive compounds and bioactivities of ginger (Zingiber officinale Roscoe). Foods, 8(6) (2019) 185
  10. M. H. Shahrajabian, W. Sun, Q. Cheng, Clinical aspects and health benefits of ginger (Zingiber officinale) in both traditional Chinese medicine and modern industry. Acta agriculturae scandinavica, section b—Soil & Plant Science, 69(6) (2019) 546-556
  11. A. P. Shirin, P. Jamuna, Chemical composition and antioxidant properties of ginger root (Zingiber officinale). Journal of Medicinal Plants Research, 4(24) (2010) 2674-2679
  12. M. Haridas, V. Sasidhar, P. Nath, J.