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Journals / Interdisciplinary Medical Journal / 2023 / Cilt: 14 Sayı: 49

Comparison of efficacy of Ketorolac %0.4 and Dexamethasone %0.1 in inflamed Pterygium and Pinguecula

Kaan ÇAKMAK
Safak KORKMAZ
Funda YILMAZ
Pages
126–131
Publication Date
2023-08-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We need more studies to support our work.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: This study investigated the effect of the ketorolac %0.4 and dexamethasone %0.1 on suppressing symptoms in inflamed pterygium and pinguecula.
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Key Findings & Data:Methods: 50 patients were included in the study.
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Conclusion & Impact:We need more studies to support our work.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Pterygium · Pinguecula · Ketorolac

Abstract

Objective: This study investigated the effect of the ketorolac %0.4 and dexamethasone %0.1 on suppressing symptoms in inflamed pterygium and pinguecula. Methods: 50 patients were included in the study. The patients were divided into two groups, each consisting of 25 patients. Ketorolac %0.4 eye drops were dropped in group 1, and dexamethasone %0.1 eye drops were started in group 2. Groups were compared 3,7,14,30,45. days in terms of total signs and symptoms. Results: After 14 days of drug administration group 1, scores were reduced %85 for total signs (2.52+1.16, p=0.001), %86 for total symptoms (4.10+2.61, p=0.001) and total scores showed a significant reduction of %86 (6.62+2.91, p=0.001) for the score. After 14 days of drug administration in group 2, scores were reduced %85 for total signs (2.70+1.46, p=0.001), %86 for total symptoms (4.25+2.36, p=0.001), and total scores showed a significant reduction of %86 (7.10+2.99, p=0.001) for the score. The scores for each sign and symptom decreased during the study. However, the statistical evaluation of each sign and symptom was similar in groups 1 and 2. There was no difference between groups 1 and 2 for total signs, total symptoms, and total score on days 3,7 and 14. No significant difference was found between groups 1 and 2 for total signs, total symptoms, and total score on days 14,30 and 45 (p>0.05). Conclusion: Current study revealed that topical ketorolac %0.4 solutions are as effective as dexamethasone in treating inflammatory pterygium and pinguecula. We suggest that it can be used alone to treat this disease. We need more studies to support our work.

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Cite This Article

ÇAKMAK, K., KORKMAZ, S., YILMAZ, F. (2023). Comparison of efficacy of Ketorolac %0.4 and Dexamethasone %0.1 in inflamed Pterygium and Pinguecula. Interdisciplinary Medical Journal, Cilt: 14 Sayı: 49, 126–131. https://ajindex.com/articles/960757

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References (12)

  1. Corn and G. Pterygium. Clinical course and treatment. Rev Int Trach Pathol Ocul Trop Subtrop Sante Publique. 1989;66(3-4):31-108.
  2. Eng-lish, French. Duke-ElderS.Systemofophthalmology:diseasesoftheouter eye, Vol 8, Part 1. London: Henry Kimpton, 1965:570–583.
  3. Austin P, Jakobiec FA, Iwamoto T. Elastodysplasia and elastodystrophy as the pathologic bases of ocular pterygia and pinguecula. Oph-thalmology. 1983 Jan;90(1):96-109. https://doi.org/10.1016/s0161-6420(83)34594-2.
  4. Detels R, Dhir SP. Pterygium: a geographical study. Arch Ophthalmol. 1967 Oct;78(4):485-91. https://doi.org/10.1001/archopht.1967.00980030487014. King JH Jr. The pterygium; brief review and evaluation of specific methods of treatment. AMA Arch Ophthalmol. 1950 Dec;44(6):854-69.
  5. Pinkerton OD, Hokama Y, Shigemura LA. Immunologic basis for the pathogenesis of pterygium. Am J Ophthalmol. 1984 Aug 15;98(2):225-8 https://doi.org/10.1016/0002-9394(87)90358-8. Wong WW. A hypothesis on the pathogenesis of pterygiums. Ann Ophthalmol. 1978 Mar;10(3):303-8.
  6. Kraff MC, Sanders DR, Jampol LM, Peyman GA, Lieberman HL. Prophylaxis of pseudophakic cystoid macular edema with topical indo-methacin. Ophthalmology. 1982 Aug;89(8):885-90. https://doi.org/10.1016/s0161-6420(82)34710-7.
  7. Turkyilmaz K, Oner V, Sevim MS, Kurt A, Sekeryapan B, Durmus M: Effect of pterygium surgery on tear osmolarity. J Ophthalmol 2013;2013:863498. Jaros P. A., DeLuise V. P. Pingueculae and pterygia. Survey of Ophthalmology. 1988;33(1):41–49. https://doi.org/10.1016/0039-6257()90071-9.
  8. Fotouhi A., Hashemi H., Khabazkhoob M., Mohammad K. Prevalence and risk factors of pterygium and pinguecula: the Tehran eye study. Eye. 2009;23(5):1125–1129. https://doi.org/10.1038/eye.2008.200.
  9. Li Z. Y., Wallace R. N., Streeten B. W., Kuntz B. L., Dark A. J. Elastic fiber components and protease inhibitors in pinguecula. Investigative Ophthalmology and Visual Science. 1991;32(5):1573–1585.
  10. Pham T. Q., Wang J. J., Rochtchina E., Mitchell P. Pterygium/pinguecula and the five-year incidence of age-related maculopathy. Ameri-can Journal of Ophthalmology. 2005;139(3):536–537. https://doi.org/10.1016/j.ajo.2004.08.070.
  11. Jobling AI, Augusteyn RC. What causes steroid cataracts? A review of steroid-induced posterior subcapsular cataracts. Clin Exp Optom. 2002 Mar;85(2):61-75. https://doi.org/10.1111/j.1444-0938.2002.tb03011.x.
  12. Keates RH, McGowan KA. The effect of topical indomethacin ophthalmic solution in maintaining mydriasis during cataract surgery. Ann Ophthalm