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Journals / Middle Black Sea Journal of Health Science / 2023 / Cilt: 9 Sayı: 3

Association of Vitamin D, IL-6, TNF-α, CRP and Periodontal Health Status in the Eastern Black Sea Region

Hatice YEMENOĞLU
Meltem ZİHNİ KORKMAZ
Medeni ARPA
Pages
498–510
Publication Date
2023-08-31
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further studies are needed on this subject.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: It is well established that vitamin D deficiency may increase risk of periodontitis, and that supplementation with vitamin D can contribute to maintain periodontal health.
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Key Findings & Data:Methods: In this study, which was planned as a case control study, it was planned to reach a total of 72 samples, with at least 24 samples in each group in the sample calculation.
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Conclusion & Impact:Further studies are needed on this subject.
🔬Design:Research Article
📍Scope:72 samples
⚙️Variables:Cytokine · gingivitis · pathogenesis of periodontal disease

Abstract

Objective: It is well established that vitamin D deficiency may increase risk of periodontitis, and that supplementation with vitamin D can contribute to maintain periodontal health. Since the Eastern Black Sea Region receives little sunlight due to its location, individuals living in this region don’t produce enough vitamin D and these individuals generally have vitamin D deficiency. The goal of this study was to analyze that association of vitamin D and periodontal health status in a study population of the Eastern Black Sea Region. Methods: In this study, which was planned as a case control study, it was planned to reach a total of 72 samples, with at least 24 samples in each group in the sample calculation. As a result of data collection, 29 individuals with periodontitis, 28 individuals with gingivitis and 25 periodontally healthy individuals, a total of 82 individuals were included in the study. Cytokines in inflamed periodontal tissues have a marked effect on host modulation and onset and progression of periodontal disease. Venous blood samples were collected from the individuals. Periodontal clinical parameters were measured. Serum levels of 1.25(OH)2D3, 25(OH)D, C-reactive protein (CRP), tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6) were assessed. Results: Periodontally healthy group had statistically significantly lower periodontal clinical parameter values compared to gingivitis and periodontitis group (p<0.05). The serum 1.25(OH)2D3 level was lower in the periodontitis group compared to the periodontally healthy group and gingivitis group (p<0.05). But there was no statistically significant difference in the periodontitis 10.20 (3.70-29.50) ng/mL, gingivitis 11.35 (5.60-29.50) ng/mL and periodontally healthy groups 9.10 (2.90-55.40) ng/mL in terms of serum 25(OH)D levels (p>0.05). Conclusion: The outcomes of this study support the idea that lower serum 1.25(OH)2D3 level has a negative effect on periodontal health status. Our data suggest that vitamin D supplementation to people living in the Eastern Black Sea Region would be beneficial in reducing the risk of developing periodontal disease. Further studies are needed on this subject.

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Cite This Article

YEMENOĞLU, H., KORKMAZ, M. Z., ARPA, M. (2023). Association of Vitamin D, IL-6, TNF-α, CRP and Periodontal Health Status in the Eastern Black Sea Region. Middle Black Sea Journal of Health Science, Cilt: 9 Sayı: 3, 498–510. https://ajindex.com/articles/959652

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