SavedAdd your journal

Journals / Journal of Health Sciences and Medicine / 2023 / Cilt: 6 Sayı: 4

Does melatonin as an antioxidant and anticancer agent potentiate the efficacy of curcumin?

Sude TOPKARAOĞLU
Alpaslan TANOĞLU
Pages
852–859
Publication Date
2023-07-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This review covers published literature studies on the effects of comparison or combined use of melatonin and curcumin as anticancer and antioxidant agents and it reveals whether melatonin potentiates the effect of curcumin when used together.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Melatonin is a hormone that exhibits many bioactivities such as antioxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic, neuroprotective, and anti-aging activity.
📊
Key Findings & Data:In addition, melatonin has been used to strengthen the effect of drugs or agents used for treatment in many different disease models such as cancer, tumor, bacterial infection, autoimmune diseases, and gastrointestinal diseases.
💡
Conclusion & Impact:This review covers published literature studies on the effects of comparison or combined use of melatonin and curcumin as anticancer and antioxidant agents and it reveals whether melatonin potentiates the effect of curcumin when used together.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Melatonin · curcumin · antioxidant

Abstract

Melatonin is a hormone that exhibits many bioactivities such as antioxidant, anti-inflammatory, anti-carcinogenic, anti-diabetic, neuroprotective, and anti-aging activity. In addition, melatonin has been used to strengthen the effect of drugs or agents used for treatment in many different disease models such as cancer, tumor, bacterial infection, autoimmune diseases, and gastrointestinal diseases. According to recent studies, curcumin is used as a pigment and powerful antioxidant and anti-inflammatory agent with therapeutic potential against various cancers. Melatonin and curcumin have been used in different models of disease or injury: such as Alzheimer's disease treatment, testicular tissue preservation, bladder cancer treatment, gastric mucosal damage, and prevention of nephrotoxicity. This review covers published literature studies on the effects of comparison or combined use of melatonin and curcumin as anticancer and antioxidant agents and it reveals whether melatonin potentiates the effect of curcumin when used together.

🔖

Cite This Article

TOPKARAOĞLU, S., TANOĞLU, A. (2023). Does melatonin as an antioxidant and anticancer agent potentiate the efficacy of curcumin?. Journal of Health Sciences and Medicine, Cilt: 6 Sayı: 4, 852–859. https://ajindex.com/articles/957512

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. Bhattacharya S, Patel KK, Dehari D, Agrawal AK, Singh S. Melatonin and its ubiquitous anticancer effects. Mol Cell Biochem. 2019;462(1-2):133-155.
  2. Meng X, Li Y, Li S, et al. Dietary sources and bioactivities of melatonin. Nutrients. 2017;9:367. Tan DX, Manchester LC, Hardeland R, Lopez-Burillo S, Mayo JC, Sainz RM. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxi- dant vitamin. J Pineal Res. 2003;34:75-78.
  3. Reiter RJ, Tan D, Sainz RM, Mayo JC, Lopez-Burillo S. Melatonin: reducing the toxicity and increasing the efficacy of drugs. Pharm Pharmacol. 2002;5410:1299-1321.
  4. Qi W, Reiter RJ, Tan DX, Manchester LC, Kim SJ, Garcia JJ. Inhibitory effects of melatonin on ferric nitrilotriacetate-induced lipid peroxidation and oxidative DNA damage in the rat kidney. Toxicology. 1999;139:81-91.
  5. Liu L, Chen H, Jin J, et al. Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation. Life Sci. 2019;239:117036. Stacchiotti A, Favero G. Giugno L, et al. Mitochondrial and metabolic dysfunction in renal convoluted tubules of obese mice: protective role of melatonin. Plos One. 2014;910:111-141.
  6. Tanoğlu EG, Tanoğlu A, Meriçöz Aydin MÇ, Esen MF. Melatonin has favorable preventive effects on experimental chronic pancreatitis rat model. Turk J Med Sci. 2021;51:2734-2740.
  7. Özçelik F, Hacimustafaoğlu F, Tanoğlu A. Modulatory effect of resveratrol and melatonin on natural killer cell activity and adrenomedullin in diabetic rats. Turk J Med Sci. 2022;521:258-267.
  8. Sapmaz T, Sevgin K, Topkaraoglu S, et al. Comparison of melatonin, oxytetracycline, and N-acetylcysteine pre-treatments in autologous intraperitoneal ovarian transplantation in rats. Biochem Biophysic Res Comm. 2022;606:49-54.
  9. Li Y, Li S, Zhou Y, et al. Melatonin for the prevention and treatment of cancer. Oncotarget. 2017;824:39896-39921.
  10. Sadeghi M, Dehnavi S, Asadirad A, et al. Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases. Inflammopharmacol. 2023:1-25
  11. Xu XY, Meng X, Li S, Gan RY, Li Y, Li HB. Bioactivity, health benefits, and related molecular mechanisms of curcumin: current progress, challenges, and perspectives. Nutrients. 2018;1010:15-53.
  12. Trujillo J, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol. 2013;11:448-456.
  13. Shoba G, Joy D. Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharm