Journals / International Archives of Medical Research / 2023 / Cilt: 15 Sayı: 1

Pseudomonas aeruginosa; Virulence Factors and Host Defense Mechanisms

Pages
48–62
Publication Date
2023-06-30
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The major virulence factors of P. aeruginosa and host immune responses against the bacteria are discussed in this review.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:As an opportunistic pathogen, Pseudomonas aeruginosa (P. aeruginosa) can cause both acute and chronic infections.
📊
Key Findings & Data:Variable virulence components and antibiotic resistance markers in the bacterium's genome constitute the bacterium's pathogenic profile and provide the bacterium with outstanding metabolic adaptability to many conditions.
💡
Conclusion & Impact:The major virulence factors of P. aeruginosa and host immune responses against the bacteria are discussed in this review.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Pseudomonas aeruginosa · virulence factors · host immune response

Abstract

As an opportunistic pathogen, Pseudomonas aeruginosa (P. aeruginosa) can cause both acute and chronic infections. Variable virulence components and antibiotic resistance markers in the bacterium's genome constitute the bacterium's pathogenic profile and provide the bacterium with outstanding metabolic adaptability to many conditions. The interactions of P. aeruginosa with the host are poorly understood, complicating the treatment of its infections and the development of vaccines against them. Despite decades of scientific research focusing specifically on this challenge, vaccines to prevent these dangerous infections still do not exist. The major virulence factors of P. aeruginosa and host immune responses against the bacteria are discussed in this review.

🔖

Cite This Article

İNCE, F. M., ÖZCAN, N., AKPOLAT, N. (2023). Pseudomonas aeruginosa; Virulence Factors and Host Defense Mechanisms. International Archives of Medical Research, Cilt: 15 Sayı: 1, 48–62. https://ajindex.com/articles/952237

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Özünel L, Boyacıoğlu Zİ, Güreser AS, Taylan-Özkan A. Evaluation of antimicrobial susceptibility patterns of Pseudomonasaeruginosa and Acinetobacterbaumannii strains isolated from deep trecheal aspirate samples in Çorum Training and Research Hospital. Turk Hij Den Biyol Derg 2014; 71(2): 81-88
  2. Xiong J, Déraspe M, Iqbal N. Complete genome of a panresistant Pseudomonas aeruginosa strain, isolated from a patient with respiratory failure in a Canadian community hospital. Genome Announc 2017; 5: e00458-17
  3. Rasamiravaka T, Labtani Q, Duez P, JaziriME. T formation of biofilm, Compounds by P.aeruginosa: A review of the natural and synthetic, interfering with control mechanisms. Biomed Res Int 2015: 759348
  4. Davis R, Brown PD. Multiple antibiotic resistance index, fitness and virulence potential in respiratory P.aeruginosa from Jamaica. J Med Microbiol 2016; 65(4): 261-271
  5. Tacconelli E, Carrara E, Savoldi A. et al. Discovery, research and development of new antibiotics: The WHO priority list of antibiotic-resistant. Lancet Infect Dis 2017; 18(3): 318-327
  6. Botelho J, Grosso F, Peixe L. Antibiotic resistance in P.aeruginosa—Mechanisms, epidemiology and evolution. Drug Resist 2019; 44: 100640
  7. Sainz-Mejías M, Jurado-Martín I, McClean S. Understanding Pseudomonas aeruginosa-Host Interactions: The Ongoing Quest for an Efficacious Vaccine. Cells 2020; 9(12): 2617
  8. Karatuna O, Yağcı A. Virulence factors of Pseudomonas aeruginosa and quorum sensing. Türk Mikrobiyol Cem Derg 2008; 38(1): 42-51
  9. Alaa A. NOD-like receptor(s) and host immune responses with Pseudomonas aeruginosa infection. Inflamm Res 2018; 67: 479–493
  10. Skariyachan S, Sridhar VS, Packirisamy S, Kumargowda ST, Challapilli SB. Recent perspectives on the molecular basis of biofilm formation by Pseudomonas aeruginosa and approaches for treatment and biofilm dispersal. Folia Microbiol 2018; 63: 413-432
  11. Laverty G, Gorman S, Gilmore B. Biomolecular mechanisms of Pseudomonas aeruginosa and Escherichia coli biofilm formation. Pathogens 2014; 3(3): 596-632
  12. Lambert PA. Mechanisms of antibiotic resistance in Pseudomonas aeruginosa. J R SocMed 2002; 95: 22-26
  13. Pier GB, Ramphal R. Pseudomonas aeruginosa. In: Mandell GL, Bennett JE, Dolin, R, eds. Mandell, Douglas and Bennett’s Principles and Practice of Infectious Disease, 7th Edition, New York: Elsevier/Churchill Livingstone, 2009: 2587-2615
  14. Opal SM, Pop-Vicas A. Molecular Mechanisms of Antibiotic Resistance in Bacteria. In