Journals / Textile and Apparel / 2010 / Cilt: 20 Sayı: 4

IN VIVO EVALUATION OF ELECTROSPUN POLY (VINYL ALCOHOL)/SODIUM ALGINATE NANOFIBROUS MAT AS WOUND DRESSING

ELEKTRO ÇEKİM YÖNTEMİ İLE ÜRETİLMİŞ POLİ(VİNİL ALKOL)/SODYUM ALGİNAT NANOLİFLİ YÜZEYİN YARA ÖRTÜSÜ OLARAK IN VIVO DEĞERLENDİRMESİ

Pages
290–298
Publication Date
2010-12-01
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

The results indicated that the electrospun PVA/NaAlg nanofibrous mat as wound dressing provided a good means for wound healing

📌 3 Key Takeaways

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Objective & Hypothesis:In this study, potential of the alginate based electrospun nanofibrous mats as wound dressings was investigated macroscopically in vivo experiments. 2/1 (v/v) %9 PVA / %1 NaAlg nanofibrous mats were produced by electrospinning method.
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Key Findings & Data:In vivo experiments, the healing performances of the wounds dressed by using cotton gauze, Bactigras, Suprasorb-A and the electrospun PVA/NaAlg nanofibrous mat were macroscopically evaluated and compared.
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Conclusion & Impact:The results indicated that the electrospun PVA/NaAlg nanofibrous mat as wound dressing provided a good means for wound healing
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Elektro çekim · Nanolif · Alginat

Abstract

In this study, potential of the alginate based electrospun nanofibrous mats as wound dressings was investigated macroscopically in vivo experiments. 2/1 (v/v) %9 PVA / %1 NaAlg nanofibrous mats were produced by electrospinning method. In order to improve water resistance of the electrospun mats, the cross-linking was performed. SEM analyses, thickness and air permeability tests were applied for the nanofibrous mats produced as wound dressing and Suprasorb-A commercial alginate wound dressing. In vivo experiments, the healing performances of the wounds dressed by using cotton gauze, Bactigras, Suprasorb-A and the electrospun PVA/NaAlg nanofibrous mat were macroscopically evaluated and compared. The wound healing potential of the electrospun mat was better than that of cotton gauze including a drug and looked like antibacterial Bactigras. The results indicated that the electrospun PVA/NaAlg nanofibrous mat as wound dressing provided a good means for wound healing

Özet

Bu çalışmada, elektro çekim yöntemi ile elde edilen alginat nanolifli yüzeylerin yara örtüsü olarak kullanım potansiyeli, gerçekleştirilen in vivo çalışmalarla makroskobik olarak değerlendirilmiştir. 2/1 hacimsel karışım oranında %9 PVA / %1 NaAlg çözeltisinden elektro çekim yöntemi ile nanolifli yüzeyler üretilmiştir. Bu yüzeylerin suya dayanımını geliştirmek için, çapraz bağlama işlemi uygulanmıştır. Yara örtüsü olarak üretilen nanolifli yüzeylere ve ticari alginatlı yara örtüsü olan Suprasorb-A’ya SEM analizleri, kalınlık ve hava geçirgenliği testleri uygulanmıştır. In vivo çalışmalarda, gazlı bez, Bactigras, Suprasorb-A ve elektro çekim ile üretilen PVA/NaAlg nanolifli yüzey ile kapatılmış yaraların yara iyileştirme performansları makroskobik olarak değerlendirilmiş ve kıyaslanmıştır. Elektro çekim yöntemi ile üretilmiş yüzeyin yara iyileştirme potansiyeli; ilaç emdirilmiş gazlı bezden daha iyi, antibakteriyel bir örtü olan Bactigras ile benzer olmuştur. Sonuçlar, PVA/NaAlg nanolifli yüzeylerin yara örtüsü olarak kullanılabilir olduğu öngörüsünü doğrulamıştır

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Cite This Article

ÜSTÜNDAĞ, G. C., KARACA, E., ÖZBEK, S., ÇAVUŞOĞLU, İ. (2010). IN VIVO EVALUATION OF ELECTROSPUN POLY (VINYL ALCOHOL)/SODIUM ALGINATE NANOFIBROUS MAT AS WOUND DRESSING. Textile and Apparel, Cilt: 20 Sayı: 4, 290–298. https://ajindex.com/articles/943864

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References (15)

  1. Ramakrishna, S., Fujihara, K., Teo, W.E., Lim, T.C., Ma, Z., 2005, An Introduction to Electrospinning and Nanofibers, World Scientific Publishing Co., Singapore, 381p
  2. Andrady, A.L., 2008, Science and Technology of Polymer Nanofibers, Wiley Pres., New Jersey, 403p
  3. Demir, M.M., Yilgor, I., Yilgor, E., Erman, B., 2002, “Electrospinning of Polyurethane Fibers”, Polymer 43(11), 3303-3309
  4. Safı, S., Morshed, M., Ravandi, H.S.A., Ghiachi, M., 2007, “Study of Electrospinning of Sodium Alginate, Blended Solutions of Sodium Alginate/Poly(vinyl alcohol) and Sodium Alginate/Poly(ethylene oxide)”, Journal of Applied Polymer Science, 104(5), 3245-3255
  5. Huang, Z.M., Zhang, Y.Z., Kotaki, M., Ramakrishna, S., 2003, “A Review on Polymer Nanofibers by Electrospinning and Their Applications in Nanocomposites”, Composites Science and Technology, 63(15), 2223-2253
  6. Özdoğan, E., Demir, A., Seventekin, N., 2006, “Nanotechnology and Its Applications in Textile Industry (Part 2)”, Tekstil ve Konfeksiyon, 16(4), 225-229
  7. Lu, J.W., Zhu, Y.L., Guo, Z.X., Hu, P., Yu, J., 2006, “Electrospinning of Sodium Alginate with Poly(ethylene oxide)”, Polymer, 47(23), 8026-8031
  8. Süpüren, G., Kanat, Z.E., Çay, A., Kırcı, T., Gülümser, T., Tarakçıoğlu, I., 2007, “Nano Fibres (Part 2)”, Tekstil ve Konfeksiyon, 17(2), 83-89
  9. Qin, Y., 2008, “Alginate Fibres: An Overview of the Production Processes and Applications in Wound Management”, Polymer International, 57, 171-180
  10. Nie, H., He, A., Zheng, J., Xu, S., Li, J., Han, C.C., 2008, ”Effects of Chain Conformation and Entanglement on the Electrospinning of Pure Alginate”, Biomacromolecules, 9(5), 1362-1365
  11. Qin, Y., 2006, “The Charactarization of Alginate Wound Dressings with Different Fiber and Textile Structures”, Journal of Applied Polymer Science, 100, 2516-2520
  12. Şen, A., Öktem, T., Seventekin, N., 2003, “The Usage of Alginate & Chitin-Chitosan Fibers as Medical Textile Materials”, Tekstil ve Konfeksiyon, 13(2), 77-85
  13. Schiffmann, J.D. and Schauer, C.L., 2008, “A review: Electrospinning of Biopolymer Nanofibers and Their Applications”, Polymer Reviews, 48(2), 317-352
  14. Lee, Y.J., Shin, D.S., Kwon, O.W., Park, W.H., Choi, H.G., Lee, Y.R., Han, S.S., Noh, S.K., Lyoo, W.S., 2007, “Preparation of Atactic Poly(vinyl alcohol)/Sodium Alginate Blend Nanowebs by Electrospinning”, Journal of Applied Polymer Science, 106(2), 1337-1342
  15. Bhattarai, N. and Zhang, M., 2007, “Controlled synthesis and structural stab