According to the obtained results, compound 2d with IC50=0.108±0.004 µM; compound 2e exhibited inhibitory activity with an IC50=0.074±0.003 µM.
📌 3 Key Takeaways
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Objective & Hypothesis:Monoamine oxidase (MAO) enzymes have an important place in neurodegenerative diseases.
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Key Findings & Data:Within the scope of this study, 7 new piperazine-dithiocarbamate derivative compounds were synthesized.
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Conclusion & Impact:According to the obtained results, compound 2d with IC50=0.108±0.004 µM; compound 2e exhibited inhibitory activity with an IC50=0.074±0.003 µM.
Monoamine oxidase (MAO) enzymes have an important place in neurodegenerative diseases. While MAO-A inhibitors are used in depression; MAO-B enzyme has an important place in Parkinson's disease. Within the scope of this study, 7 new piperazine-dithiocarbamate derivative compounds were synthesized. Structure determinations of the compounds were performed using 1H-NMR, 13C-NMR and HRMS spectroscopic methods. The MAO inhibitory activities of the compounds were determined by in vitro fluorometric methods. According to the obtained results, compound 2d with IC50=0.108±0.004 µM; compound 2e exhibited inhibitory activity with an IC50=0.074±0.003 µM.
OSMANİYE, D., SAGLİK, B. N., LEVENT, S., ÖZKAY, Y., KAPLANCIKLI, Z. A. (2022). Synthesis and characterization of new Piperazine-Dithiocarbamate compounds as potent MAO-A inhibitors. European Journal of Life Sciences, Cilt: 1 Sayı: 1, 1–7. https://ajindex.com/articles/919628
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