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Journals / European Journal of Life Sciences / 2026 / Volume: 3 Issue: 2

Investigation of dual AChE/MAO inhibitory activities of new morpholine and piperazine structured compounds

Berkant Kurban(Afyonkarahisar Sağlık Bilimleri Üniversitesi, Eczacılık Fakültesi)0000-0002-1595-3870
Derya Osmaniye(ANADOLU UNIVERSITY, FACULTY OF PHARMACY)0000-0002-0499-436X
Begüm Nurpelin Sağlık Özkan(ANADOLU UNIVERSITY, FACULTY OF PHARMACY)0000-0002-0151-6266
Zafer Asım Kaplancıklı(ANADOLU UNIVERSITY, FACULTY OF PHARMACY)0000-0003-2252-0923
Pages
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Publication Date
2024-08-30
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Compounds 3a and 3b had the highest affinity for the AChE and MAO-B enzymes.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:In this study, a series of new compounds containing piperazine and morpholine rings were synthesized.
📊
Key Findings & Data:Characterization studies of the obtained compounds were carried out with the help of HRMS, 1H-NMR and 13C-NMR spectroscopic methods.
💡
Conclusion & Impact:Compounds 3a and 3b had the highest affinity for the AChE and MAO-B enzymes.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:AChE · MAO-B · Piperazine

Abstract

In this study, a series of new compounds containing piperazine and morpholine rings were synthesized. Characterization studies of the obtained compounds were carried out with the help of HRMS, 1H-NMR and 13C-NMR spectroscopic methods. Acetylcholinesterase (AChE) / Monoamine oxidase B (MAO-B) inhibitory potentials of the compounds were investigated using in silico and in vitro methods. Compound 3a was the compound with the highest inhibitory potential against AChE and MAO-B enzymes, with IC50=0.065±0.002 µM and IC50=0.072±0.003 µM values, respectively. Compounds 3a and 3b interacted with crucial amino acid residues of the hMAO-B (PDB ID: 2V5Z) and AChE (PDB ID: 4EY7) enzymes in the docking studies. Compounds 3a and 3b had the highest affinity for the AChE and MAO-B enzymes.

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Cite This Article

Kurban, B., Osmaniye, D., Özkan, B. N. S., Kaplancıklı, Z. A. (2024). Investigation of dual AChE/MAO inhibitory activities of new morpholine and piperazine structured compounds. European Journal of Life Sciences, Volume: 3 Issue: 2. https://doi.org/10.55971/EJLS.1497639

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