AI Summary & Key Takeaways
AI InsightResults: Total 172 mCRC patients had received mFOLFIRI-B regime in the second-line treatment. 39.5% objective response rate, 9.0 months (7.6 to 10.3) median progression-free survival, 19.0 months (15.1 to 26.2) median overall survival were found.
📌 3 Key Takeaways
Abstract
We aimed to investigate the efficacy and tolerability of modified FOLFIRI-Bevacizumab (mFOLFIRI-B) regime in the secondline treatment of metastatic colorectal cancer (mCRC) patients who received oxaliplatin-based regimen in the first-line treatment. Material and Method: The patients treated with mFOLFIRI-B regimen in second-line therapy who had progressed after oxaliplatin- based chemotherapy were included in this study. The datas of toxicity and efficacy of the regimen were retrospectively evaluated. Results: Total 172 mCRC patients had received mFOLFIRI-B regime in the second-line treatment. 39.5% objective response rate, 9.0 months (7.6 to 10.3) median progression-free survival, 19.0 months (15.1 to 26.2) median overall survival were found. Grade 3/4 toxicity was observed in 33.7%. Grade 3/4 hematologic toxicity was most frequently observed toxicity (31.9%). Conclusion: mFOLFIRI-B is an efficient and safe regimen for the second-line treatment of mCRC patients after the oxaliplatinbased regimen.
Özet
İlk-sıra tedavide oksaliplatin-temelli rejim alan metastatik kolorektal kanserli (mKRK) hastalarda ikinci-sıra tedavide modifiye FOLFIRI-Bevacizumab (mFOLFIRI-B) rejiminin etkinlik ve tolerabilitesi araştırıldı. Materyal ve Metot: Çalışmaya ilk-sıra tedavide oksaliplatin-temelli rejim alan, ardından progresyon gözlenen ve ikinci-sıra tedavide mFOLFIRI-B rejimi alan mKRK’li hastalar alındı. Toksisite ve etkinlik ile ilgili veriler retrospektif olarak değerlendirildi.Bulgular: Toplam 172 mKRK’li hasta ikinci-sıra tedavide mFOLFIRI-B rejimi almıştı. Hastaların %39,5’inde objektif cevap, 9,0 aylık (7,6 ile 10,3 arası) median progresyonsuz yaşam, 19,0 aylık (15,1 ile 26,2 arası) median tüm yaşam saptandı. Grade 3/4 toksisite %33,7 oranında tespit edildi. Grade 3/4 hematolojik toksisite %31,9 oranında tespit edildi. Sonuç: Sonuç olarak mKRK’li hastalarda oksaliplatin-temelli rejim sonrası ikinci-sıra tedavide mFOLFIRI-B rejimi etkili ve güvenilir bir tedavi rejimidir.