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Journals / Cukurova Medical Journal / 2023 / Cilt: 48 - Sayı: 1

Triglyceride-glucose index is associated with residual SYNTAX score in patients with ST-segment elevation myocardial infarction

Trigliserit-glikoz indeksi ST-segment yükselmeli miyokard enfarktüslü hastalarda rezidüel SYNTAX skoru ile ilişkilidir

Yalçın AVCI
Ali Rıza DEMİR
Arda GÜLER
Tugba AKTEMUR
Serkan KAHRAMAN
Begüm UYGUR
Gökhan DEMİRCİ
Enes ARSLAN
Ahmet Emir ULUTAŞ
Mehmet ERTURK
Pages
92–100
Publication Date
2023-03-31
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: High TyG index had a strong association with rSS and higher TyG index was an independent predictor of increased rSS in patients with STEMI

📌 3 Key Takeaways

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Objective & Hypothesis:Purpose: The triglyceride-glucose index (TyG) is an important parameter that reflects insulin resistance and its use has increased recently.
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Key Findings & Data:Materials and Methods: A total of 663 STEMI patients who underwent primary percutaneous coronary intervention were included in the study.
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Conclusion & Impact:Conclusion: High TyG index had a strong association with rSS and higher TyG index was an independent predictor of increased rSS in patients with STEMI
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Trigliserid- glukoz indeksi · St yükselmeli miyokart enfarktüsü · rezidüel SYNTAX skoru

Abstract

Purpose: The triglyceride-glucose index (TyG) is an important parameter that reflects insulin resistance and its use has increased recently. Its relationship with cardiovascular diseases has been shown in previous studies. Our aim was to investigate the association of residual SYNTAX score (rSS) with TyG index in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention. Materials and Methods: A total of 663 STEMI patients who underwent primary percutaneous coronary intervention were included in the study. The patients were divided into 2 groups according to the TyG index level as high and low. The cut-off value for the TyG index was determined as 9.61 by ROC analysis. Coronary artery disease severity was calculated for both groups besides baseline clinical and demographic variables. Results: A total of 281 patients were evaluated in the high TyG index group and 386 patients in the low TyG index group. A rSS above 8 was considered high. The proportion of patients with high rSS in the increased TyG index group was found to be significantly higher than in the other group [114 (40.6) vs. 54 (14.0)]. In addition, higher TyG index is determined to be the independent predictor of higher rSS in logistic regression analysis. Conclusion: High TyG index had a strong association with rSS and higher TyG index was an independent predictor of increased rSS in patients with STEMI

Özet

Amaç: Trigliserit-glukoz indeksi (TyG) insülin direncini yansıtan önemli bir parametredir ve son yıllarda kullanımı artmıştır. Kardiyovasküler hastalıklarla ilişkisi daha önceki çalışmalarda gösterilmiştir. Amacımız, primer perkütan koroner girişim uygulanan ST segment yükselmeli miyokard enfarktüsü (STEMI) hastalarında rezidüel SYNTAX skorunun (rSS) TyG indeksi ile ilişkisini araştırmaktır. Gereç ve Yöntem: Çalışmaya primer perkütan koroner girişim uygulanan toplam 663 STEMI hastası dahil edildi. Hastalar, TyG indeks düzeyine göre yüksek ve düşük olmak üzere iki gruba ayrıldı. TyG indeksi için cut-off değeri ROC analizi ile 9,61 olarak belirlendi. Başlangıç klinik ve demografik değişkenlerin yanı sıra koroner arter hastalığı şiddeti her iki grup için de hesaplandı. Bulgular: Yüksek TyG indeksi grubunda 281 hasta ve düşük TyG indeksi grubunda 386 hasta değerlendirildi. 8'in üzerindeki rSS, yüksek olarak kabul edildi. Artmış TyG indeksi grubunda yüksek rSS olan hastaların oranı diğer gruba göre anlamlı derecede yüksek bulundu [114 (40.6) vs. 54 (14.0]. Ek olarak, lojistik regresyon analizinde daha yüksek TyG indeksi, daha yüksek rSS’nin bağımsız öngörücüsü olarak belirlenir. Sonuç: Yüksek TyG indeksi, rSS ile güçlü bir ilişkiye sahiptir ve daha yüksek TyG indeksi, STEMI hastalarında artan rSS'nin bağımsız bir öngördürücüsüdür.

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Cite This Article

AVCI, Y., DEMİR, A. R., GÜLER, A., AKTEMUR, T., KAHRAMAN, S., UYGUR, B., DEMİRCİ, G., ARSLAN, E., ULUTAŞ, A. E., ERTURK, M. (2023). Triglyceride-glucose index is associated with residual SYNTAX score in patients with ST-segment elevation myocardial infarction. Cukurova Medical Journal, Cilt: 48 - Sayı: 1, 92–100. https://ajindex.com/articles/885378

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References (7)

  1. Lee JH, Park HS, Chae SC, Cho Y, Yang DH, Jeong MH et al. Predictors of six-month major adverse cardiac events in 30-day survivors after acute myocardial infarction (from the Korea Acute Myocardial Infarction Registry). Am J Cardiol. 2009;104:182-9.
  2. Toma M, Buller CE, Westerhout CM, Fu Y, O’Neill WW, Holmes DR et al. Non-culprit coronary artery percutaneous coronary intervention during acute ST-segment elevation myocardial infarction: insights from the APEX-AMI trial. Eur Heart J. 2010;31:1701-7. Généreux P, Palmerini T, Caixeta A, Rosner G, Green P, Dressler O et al. Quantification and impact of untreated coronary artery disease after percutaneous coronary intervention: the residual SYNTAX (Synergy Between PCI with Taxus and Cardiac Surgery) score. J Am Coll Cardiol. 2012;59:2165-74.
  3. Patel TP, Rawal K, Bagchi AK, Akolkar G, Bernardes N, Dias D da S et al. Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes. Heart Fail Rev. 2016;21:11-23.
  4. Leon BM, Maddox TM. Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 2015;6:1246-58.
  5. Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuñiga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol. 2018;17:122. Petersen MC, Shulman GI. Mechanisms of insulin action and insulin resistance. Physiol Rev. 2018;98:2133-223.
  6. Tam CS, Xie W, Johnson WD, Cefalu WT, Redman LM, Ravussin E. Defining insulin resistance from hyperinsulinemic-euglycemic clamps. Diabetes Care. 2012;35:1605-10. Sánchez-García A, Rodríguez-Gutiérrez R, Mancillas-Adame L, González-Nava V, Díaz González-Colmenero A, Solis RC et al. Diagnostic accuracy of the triglyceride and glucose index for insulin resistance: A systematic review. Int J Endocrinol. 2020;2020:e4678526. Liu X cong, He G dong, Lo K, Huang Y qing, Feng Y qing. The triglyceride-glucose index, an insulin resistance marker, was non-linear associated with all-cause and cardiovascular mortality in the general population. Front Cardiovasc Med 2021;7. Si Y, Fan W, Han C, Liu J, Sun L. Atherogenic index of plasma, triglyceride-glucose index and monocyte-to-lymphocyte ratio for predicting subclinical coronary artery disease. Am J Med Sci. 2021;362:285-90.
  7. Jin JL, Cao YX, Wu LG, You XD, Guo YL, Wu NQ et al. Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary arte